Validity of the Mood Disorder Questionnaire: A General Population Study

Hirschfeld, Robert M. A.; Hölzer, Charles E.; Calabrese, Joseph R.; Weissman, Myrna M.; Reed, Michael L.; Davies, Marilyn A.; Frye, Mark A.; Keck, Paul E.; McElroy, Susan L.; Lewis, Lydia; Tierce, Jonathan; Wagner, Karen Dineen; Hazard, Elizabeth W.

doi:10.1176/appi.ajp.160.1.178

Cited by 261 publications

(217 citation statements)

References 2 publications

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“…11,20,[22][23][24] It was comparable to other instruments such as the MDQ. 26,29 This reliability is similar to values found in samples of remitted patients (Italy, Spain, and Sweden) 11,20 and also in the general population (Germany and Sweden). 33 This indicates stable psychometric properties, regardless of clinical status or cultural differences.…”

Section: Discussionsupporting

confidence: 85%

“…In addition, we contrasted the HCL-32 VB with the Mood Disorder Questionnaire (MDQ), a screening instrument largely used for improving the identification of BD. 26 Its English version was shown to have a sensitivity of 73% and a specificity of 90% for a sample consisting mostly of BD-I patients. In the development study, the MDQ was more efficient in identifying BD-I than BD-II.…”

Section: Introductionmentioning

confidence: 99%

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Reliability and validity of a Brazilian version of the Hypomania Checklist (HCL-32) compared to the Mood Disorder Questionnaire (MDQ)

Soares

Moreno

Moura

et al. 2010

Rev. Bras. Psiquiatr.

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Objective: Bipolar disorders are often not recognized and undertreated. The diagnosis of current or past episodes of hypomania is of importance in order to increase diagnostic certainty. The Hypomania Checklist-32 is a self-applied questionnaire aimed at recognizing these episodes. As part of the international collaborative effort to develop multi-lingual versions of the Hypomania Checklist-32, we aimed to validate the Brazilian version and to compare its psychometric properties with those of the Mood Disorder Questionnaire. Method: Adult outpatients with bipolar disorder I (n = 37), bipolar disorder II (n = 44) and major depressive disorder (n = 42) of a specialized mood disorder unit were diagnosed according to DSM-IV-TR using a modified version of the SCID. We analyzed the internal consistency and discriminative ability of the Hypomania Checklist-32 Brazilian version in relation to the Mood Disorder Questionnaire. Results: The internal consistency of the Brazilian Hypomania Checklist-32, analyzed using Cronbach's alpha coefficient, was 0.86. A score of 18 or higher in the Hypomania Checklist-32 Brazilian version distinguished between bipolar disorder and major depressive disorder, with a sensitivity of 0.75 and a specificity of 0.58, compared to 0.70 and 0.58, respectively, for the Mood Disorder Questionnaire (score ≥ 7). The Hypomania Checklist-32 Brazilian version showed a dual factor structure characterized by "active/elated" and "risk-taking/ irritable" items. Hence, the Hypomania Checklist-32 Brazilian version was found to have a higher sensitivity but the same specificity as the Mood Disorder Questionnaire. Conclusion: The Brazilian version of the Hypomania Checklist-32 has adequate psychometric properties and helps discriminating bipolar disorder from major depressive disorder (but not bipolar disorder I from bipolar disorder II) with good sensitivity and specificity indices, similar to those of the Mood Disorder Questionnaire. Resumo Objetivo: O transtorno bipolar muitas vezes não é reconhecido e deixa de ser tratado adequadamente. O diagnóstico de episódios atuais ou passados é importante, a fim de aumentar a certeza diagnóstica. O Questionário de Autoavaliação de Hipomania-32 é um questionário autoaplicável para o rastreamento desses episódios. Como parte do desenvolvimento em vários idiomas do Questionário de Autoavaliação de Hipomania-32, nós objetivamos validar a versão brasileira e comparar suas propriedades psicométricas com o Questionário de Transtornos do Humor. Método: Em uma unidade especializada em transtornos do humor foram selecionados pacientes ambulatoriais adultos com transtorno bipolar I (n = 37), transtorno bipolar II (N = 44) e transtorno depressivo maior (N = 42) de acordo com a DSM-IV-TR

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Reliability and validity of a Brazilian version of the Hypomania Checklist (HCL-32) compared to the Mood Disorder Questionnaire (MDQ)

Soares

Moreno

Moura

et al. 2010

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…'; Hirschfeld et al, 2000). Originally designed and validated for use in outpatient populations, the MDQ has since been validated in the general population (specificity ¼ 0.97; Hirschfeld et al, 2003), and has been used to define the common bipolar phenotype in terms of elevated mood in young people (Rock et al, 2010). Specifically, two participant groups were recruited: participants with MDQ scores ¼ 0 (control participants), and participants with MDQ scoresX7 (BPP).…”

Section: Participants and Recruitmentmentioning

confidence: 99%

Reduced Subjective Response to Acute Ethanol Administration Among Young Men with a Broad Bipolar Phenotype

Yip

Doherty

Wakeley

et al. 2012

Neuropsychopharmacol

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Elevated lifetime prevalence rates of alcohol use disorders (AUDs) are a feature of bipolar disorder (BD). Individuals at-risk for AUDs exhibit blunted subjective responses to alcohol (low levels of response), which may represent a biomarker for AUDs. Thus, individuals atrisk for BD may exhibit low responses to alcohol. Participants were 20 unmedicated adult males who reported high rates of hypomanic experiences (bipolar phenotype participants; BPPs), aged 18 to 21 years, and 20 healthy controls matched on age, gender, IQ, BMI, and weekly alcohol intake. Subjective and pharmacokinetic responses to acute alcohol (0.8 g/kg) vs placebo administration were collected in a randomized, double-blind, cross-over, placebo-controlled, within-subjects design. BPP participants reported significantly lower subjective intoxication effects ('feel high': F ¼ 14.2, p ¼ 0.001; 'feel effects': F ¼ 8.1, p ¼ 0.008) across time, but did not differ in their pharmacokinetic, stimulant, or sedative responses. Paradoxically, however, the BPP participants reported significantly higher expectations of the positive effects of alcohol than controls. Our results suggest that unmedicated young males with previous hypomanic experiences exhibit diminished subjective responses to alcohol. These blunted alcohol responses are not attributable to differences in weekly alcohol intake, pharmacokinetic effects (eg, absorption rates), or familial risk of AUDs. These observations suggest that the dampened intoxication may contribute to the increased rates of alcohol misuse in young people at-risk for BD, and suggest possible shared etiological factors in the development of AUDs and BD.

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“…At the original cut-off of seven items, its sensitivity was higher than the English version for detecting SCID diagnosis of bipolar disorder in the community (28.1%) (Hirschfeld et al, 2003), but its specificity was lower. It also demonstrated a higher sensitivity than in a previous community study that, with regard to DSM-IV bipolar disorder, found the MDQ to have zero sensitivity (0) and high specificity (0.95) (Chung et al, 2009).…”

Section: Discussionmentioning

confidence: 82%

Test performance of the Cantonese Chinese Mood Disorder Questionnaire for detecting bipolar spectrum disorder in the community of Hong Kong

Lee

Tsang

et al. 2011

Epidemiol Psychiatr Sci

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Validity of the Mood Disorder Questionnaire: A General Population Study

Abstract: The Mood Disorder Questionnaire is a useful screening instrument for bipolar I and II disorders in the community. The operating characteristics of the Mood Disorder Questionnaire in the general population differ substantially from its characteristics in outpatient psychiatric settings.

Cited by 261 publications

References 2 publications

Reliability and validity of a Brazilian version of the Hypomania Checklist (HCL-32) compared to the Mood Disorder Questionnaire (MDQ)

Reliability and validity of a Brazilian version of the Hypomania Checklist (HCL-32) compared to the Mood Disorder Questionnaire (MDQ)

Reduced Subjective Response to Acute Ethanol Administration Among Young Men with a Broad Bipolar Phenotype

Test performance of the Cantonese Chinese Mood Disorder Questionnaire for detecting bipolar spectrum disorder in the community of Hong Kong

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