Validity of the Ankylosing Spondylitis Disease Activity Score (ASDAS) in patients with early spondyloarthritis from the Esperanza programme

Fernández-Espartero, Cruz; Miguel, Eugenio de; Loza, Estíbaliz; Tomero, Eva; Gobbo, Milena; Descalzo, Miguel Ángel; Estévez, E. Collantes; Mulero, Juan; Muñóz-Fernández, Santiago; Zarco, Pedro; Carmona, Loreto

doi:10.1136/annrheumdis-2012-202976

Cited by 48 publications

(29 citation statements)

References 10 publications

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“…ASDAS has been validated in several cohorts and different subgroups of patients with AS. Espartero et al conducted a study in 672 early SpA patients and reported that ASDAS had a high validity in the assessment of disease and performed similarly as in patients with AS [29]. There is only one study investigated the validity of ASDAS in the assessment disease activity in patients with axPsA [14].…”

Section: Discussionmentioning

confidence: 99%

Comparison of ASDAS and BASDAI as a measure of disease activity in axial psoriatic arthritis

Kılıç

Nas

et al. 2014

Clin Rheumatol

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The aim of this study was to compare the discriminative ability of Ankylosing Spondylitis Disease Activity Score (ASDAS) with Bath Ankylosing Spondylitis Activity Disease Activity Index (BASDAI) and other clinical disease activity parameters in patients with axial psoriatic arthritis (axPsA). Patients with axPsA were recruited from Erciyes Spondyloarthritis Cohort (ESPAC) and Anatolian Group for the Assessment in Rheumatic Disease (ANGARD) cohort and were assessed for BASDAI, ASDAS, BASFI (Bath Ankylosing Spondylitis Functional Index), Ankylosing Spondylitis Quality of Life (ASQoL), and visual analog scale (VAS) pain. The discriminant ability of ASDAS-C-reactive protein (-CRP) and ASDAS-erythrocyte sedimentation rate (-ESR) was assessed using standardized mean differences between patients with high and low disease activity. Fifty-four patients with axPsA were included in the study. Both ASDAS scores showed good discriminative ability between high and low disease activity states. Both ASDAS versions and BASDAI had relatively high area under the curve (AUC) according to ASAS partial remission, patient and physician global assessments in receiver operating characteristic (ROC) curve analysis. There was no significant difference between AUC scores for the models that compared ASDAS-CRP and ASDAS-ESR with BASDAI for each individual definition of disease activity states. ASDAS versions and BASDAI showed good similar discriminative ability between high and low disease activity as reflected by the AUC analysis in axPsA. The cutoff values for inactive disease and high disease activity were relatively similar to predefined cutoff values for AS. Further, prospective validation is now required to identify the appropriate assessment tools and cutoff values in axPsA.

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Section: Discussionmentioning

confidence: 99%

Comparison of ASDAS and BASDAI as a measure of disease activity in axial psoriatic arthritis

Kılıç

Nas

et al. 2014

Clin Rheumatol

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“…Originally, it was calculated by two formulas according to the acute phase reactants used (either C-reactive protein [CRP] or erythrocyte sedimentation rate [ESR]), and the ASDAS-CRP was reported as the preferred formula [6]. The discriminative ability and the sensitivity to change of the ASDAS have been tested in multiple databases and clinical trials, and it was also further validated in various populations [1,[7][8][9][10][11][12][13][14][15]. However, the calculation of the ASDAS can be relatively complex and requires a calculator.…”

Section: Introductionmentioning

confidence: 99%

Performance characteristics of the simplified version of ankylosing spondylitis disease activity score (SASDAS)

et al. 2015

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Various types of disease activity measures are available for axial spondyloarthritis (axSpA), and there is no gold standard for all individual patients. The ankylosing spondylitis disease activity score (ASDAS) is highly discriminatory, sensitive to change, and associated with structural progression. A simplified version of the ASDAS (SASDAS) was proposed and found to be a simple and practical tool to assess disease activity. Our aim was to test the performance characteristics of the SASDAS and compare it with validated tools. In total, 97 consecutive ankylosing spondylitis (AS) patients were included in the study. Disease activity was assessed by the ASDAS-erythrocyte sedimentation rate (ESR), ASDAS-C-reactive protein (CRP), bath ankylosing spondylitis disease activity index (BASDAI), and SASDAS. The relationship among these activity indices and the level of agreement of various activity categories were tested. There was a strong correlation between the SASDAS and other activity indices, including the BASDAI (r = 0.916, p < 0.001), ASDAS-CRP (r = 0.847, p < 0.001), and ASDAS-ESR (r = 0.942, p < 0.001). Although the agreement between the ASDAS-ESR and SASDAS was good (weighted kappa of 0.744 and total agreement of 77 %), there was moderate agreement between the ASDAS-CRP and SASDAS (weighted kappa of 0.579 and total agreement of 66 %). The disagreement was particularly striking in "moderate" and "high disease activity" states. Approximately 40 % of patients classified as moderate activity according to the ASDAS-ESR and 45 % according to the ASDAS-CRP were differentially categorized by the SASDAS. The results of the present analysis suggest that the simplified version of the ASDAS-ESR should be further validated in various settings and populations due to a questionable level of agreement between the ASDAS-CRP and SASDAS.

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“…Given its face validity and its psychometric properties,13 14 we proposed to use ASDAS to define the trajectories of disease activity over time in an axSpA cohort.…”

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confidence: 99%

Disease activity trajectories in early axial spondyloarthritis: results from the DESIR cohort

et al. 2016

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Validity of the Ankylosing Spondylitis Disease Activity Score (ASDAS) in patients with early spondyloarthritis from the Esperanza programme

Cited by 48 publications

References 10 publications

Comparison of ASDAS and BASDAI as a measure of disease activity in axial psoriatic arthritis

Comparison of ASDAS and BASDAI as a measure of disease activity in axial psoriatic arthritis

Performance characteristics of the simplified version of ankylosing spondylitis disease activity score (SASDAS)

Disease activity trajectories in early axial spondyloarthritis: results from the DESIR cohort

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