Validity of the ALS-Depression-Inventory (ADI-12)— A new screening instrument for depressive disorders in patients with amyotrophic lateral sclerosis

Hammer, Eva Maria; Häcker, Sonja; Hautzinger, Martin; Meyer, Thomas D.; Kübler, Andrea

doi:10.1016/j.jad.2007.11.012

Cited by 86 publications

(75 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For patients with carcinoma, however, depressive symptoms have been reported to correlate with the extent of physical impairment (Frick et al, 2007). The prevalence of depression diagnosed with a struc tured interview according to DSM-IV criteria among ALS patients is around 9-11% (Ganzini et al, 1999;Rabkin et al, 2000Rabkin et al, , 2005Kurt et al, 2007;Hammer et al, 2008) -which is only slightly higher than that observed in the general population (4-7%, Narrow et al, 2002, Kessler et al, 2003 yet lower than among patients with multiple sclerosis (up to 46%, Feinstein and Feinstein, 2001;Galeazzi et al, 2005). Diseaseindependent factors like level of education (num ber of school years) correlated significantly with the prevalence of depression in ALS.…”

Section: Depression Ratementioning

confidence: 99%

Life can be worth living in locked-in syndrome

Lulé

Zickler

Häcker

et al. 2009

Progress in Brain Research

168

104

View full text Add to dashboard Cite

The locked-in syndrome (LIS) describes patients who are awake and conscious but severely deefferented leaving the patient in a state of almost complete immobility and loss of verbal communication. The etiology ranges from acute (e.g., brainstem stroke, which is the most frequent cause of LIS) to chronic causes (e.g., amyotrophic lateral sclerosis; ALS). In this article we review and present new data on the psychosocial adjustment to LIS. We refer to quality of life (QoL) and the degree of depressive symptoms as a measure of psychosocial adjustment. Various studies suggest that despite their extreme motor impairment, a significant number of LIS patients maintain a good QoL that seems unrelated to their state of physical functioning. Likewise, depression is not predicted by the physical state of the patients. A successful psychological adjustment to the disease was shown to be related to problem-oriented coping strategies, like seeking for information, and emotional coping strategies like denial -the latter may, nevertheless, vary with disease stage. Perceived social support seems to be the strongest predictor of psychosocial adjustment. QoL in LIS patients is often in the same range as in age-matched healthy individuals. Interestingly, there is evidence that significant others, like primary caregivers or spouses, rate LIS patients' QoL significantly lower than the patients themselves. With regard to depressed mood, ALS patients without symptoms focus significantly more often on internal factors that can be retained in the course of the disease contrary to patients with depressive symptoms who preferably name external factors as very important, such as health, which will degrade in the course of the disease. Typically, ALS patients with a higher degree of depressive symptoms experience significantly less ''very pleasant'' situations. The herein presented data strongly question the assumption among doctors, health-care workers, lay persons, and politicians that severe motor disability necessarily is intolerable and leads to end-of-life decisions or euthanasia. Existing evidence supports that biased clinicians provide less-aggressive medical treatment in LIS patients. Thus, psychological treatment for depression, effective strategies for coping with the disease, and support concerning the maintenance of the social network are needed to cope with the disease. Novel communication devices and assistive technology now offers an increasing number of LIS patients to resume a meaningful life and an active role in society.

show abstract

Section: Depression Ratementioning

confidence: 99%

Life can be worth living in locked-in syndrome

Lulé

Zickler

Häcker

et al. 2009

Progress in Brain Research

168

104

View full text Add to dashboard Cite

show abstract

“…[12][13][14][15] Of the 62 patients (19%) who expressed a wish to die, only 23 (37%) were clinically depressed.…”

mentioning

confidence: 99%

Cognitive impairment, behavioral impairment, depression, and wish to die in an ALS cohort

et al. 2016

View full text Add to dashboard Cite

Objective: To evaluate relationships among cognitive, behavioral, and psychiatric/psychosocial measures assessed in a multicenter cohort of patients with amyotrophic lateral sclerosis (ALS). Methods:Recently diagnosed patients with definite or probable ALS diagnosis were administered 7 standardized psychiatric/psychosocial measures, including the Patient Health Questionnaire for diagnosis of depression and elicitation of wish to die. The Cognitive Behavioral Screen was used to classify both cognitive and behavioral impairment (emotional-interpersonal function). An ALS version of the Frontal Behavioral Inventory and Mini-Mental State Examination were also administered.Results: Of 247 patients included, 79 patients (32%) had neither cognitive nor behavioral impairment, 100 (40%) had cognitive impairment, 23 (9%) had behavioral impairment, and 45 (18%) had comorbid cognitive and behavioral decline. Cognitive impairment, when present, was in the mild range for 90% and severe for 10%. Thirty-one patients (12%) had a major or minor depressive disorder (DSM-IV criteria). Cognitive impairment was unrelated to all psychiatric/psychosocial measures. In contrast, patients with behavioral impairment reported more depressive symptoms, greater hopelessness, negative mood, and more negative feedback from spouse or caregiver. A wish to die was unrelated to either cognitive or behavioral impairment.Conclusions: While we found no association between cognitive impairment and depression or any measure of distress, behavioral impairment was strongly associated with depressive symptoms and diagnoses although seldom addressed by clinicians. Thoughts about ending life were unrelated to either cognitive or behavioral changes, a finding useful to consider in the context of policy debate about physician-assisted death.

show abstract

“…(Cummings et al, 1994). (C) ALS Depression Inventory (ADI) (Hammer et al, 2008) and the Beck Depression Inventory (BDI) (Beck and Beamesderfer, 1974) were used to evaluate depressive symptoms. All tests were administered in a computerized version.…”

Section: Neuropsychological Testingmentioning

confidence: 99%

Reaching and grasping a glass of water by locked-in ALS patients through a BCI-controlled humanoid robot

Spataro¹,

Sorbello²,

Tramonte³

et al. 2015

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Locked-in Amyotrophic Lateral Sclerosis (ALS) patients are fully dependent on caregivers for any daily need. At this stage, basic communication and environmental control may not be possible even with commonly used augmentative and alternative communication devices. Brain Computer Interface (BCI) technology allows users to modulate brain activity for communication and control of machines and devices, without requiring a motor control. In the last several years, numerous articles have described how persons with ALS could effectively use BCIs for different goals, usually spelling. In the present study, locked-in ALS patients used a BCI system to directly control the humanoid robot NAO (Aldebaran Robotics, France) with the aim of reaching and grasping a glass of water. Four ALS patients and four healthy controls were recruited and trained to operate this humanoid robot through a P300-based BCI. A few minutes training was sufficient to efficiently operate the system in different environments. Three out of the four ALS patients and all controls successfully performed the task with a high level of accuracy. These results suggest that BCI-operated robots can be used by locked-in ALS patients as an artificial alter-ego, the machine being able to move, speak and act in his/her place.

show abstract

Validity of the ALS-Depression-Inventory (ADI-12)— A new screening instrument for depressive disorders in patients with amyotrophic lateral sclerosis

Cited by 86 publications

References 23 publications

Life can be worth living in locked-in syndrome

Life can be worth living in locked-in syndrome

Cognitive impairment, behavioral impairment, depression, and wish to die in an ALS cohort

Reaching and grasping a glass of water by locked-in ALS patients through a BCI-controlled humanoid robot

Contact Info

Product

Resources

About