Background: Malnutrition is a common problem, which may exacerbate gastrointestinal symptoms, reduce treatment efficiency, and deteriorate hemodynamic stability in hemodialysis (HD) patients. Objectives: This study aimed to investigate nutritional status and gastrointestinal health in HD patients and to determine the association of these variables with laboratory parameters and dialysis adequacy in Semnan, Iran in 2016. Methods: This cross sectional study was conducted on 80 patients with a minimum 6-month history of HD. Gastrointestinal health and nutritional status were assessed using gastrointestinal symptom rating scale and subjective global assessment, respectively. The laboratory parameters included alkaline phosphatase, urea, creatinine, albumin, iron, hemoglobin, hematocrit, and blood sugar. Results: Overall, 27.5% of the patients had mild to moderate malnutrition, while 72.5% had a good nutritional status. The most common digestive problem was constipation (83.7%).