Validity of Immunochromatographic Test for Antibody in Diagnosis of Typhoid Fever in Children Admitted in A Tertiary Care Hospital

Choudhury, Zabeen; Karim, Mohammad Rezaul; Samad, Rasheda; Islam, Shanjana

doi:10.3329/cmoshmcj.v16i2.37288

Cited by 2 publications

(3 citation statements)

References 11 publications

(14 reference statements)

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“…They suggested that rather than using Widal test it might be more useful to use rapid test like Typhi-dot in routine diagnostic service besides blood culture. Studies from Bangladesh reported similar rate of sensitivity and specificity of a rapid ICT (SD Bioline) and TUBEX® for the diagnosis of typhoid fever [45,46]. This is in agreement with our findings.…”

Section: Discussionsupporting

confidence: 92%

“…Only IgM (early phase) or both IgM and IgG positive (middle phase) indicates current infection and IgG without IgM usually denotes past, reinfection or late stage disease when sero-conversion has already been occurred. In this study we observed the percentages of IgG positive cases among culture positive group was high, but in other studies conducted through different ICT kit found more IgM positive cases [45]. This could be explained by the disappearance of IgM in the late stage of disease or masking of IgM by IgG [50].…”

Section: Discussioncontrasting

confidence: 53%

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Comparative evaluation of rapid Salmonella Typhi IgM/IgG and Widal test for the diagnosis of enteric fever

Akter¹,

Yeasmin²,

Alam³

et al. 2020

IMC J Med Sci

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Background: Accurate and early diagnosis of enteric fever is a diagnostic challenge where facility for blood culture is not available. As a result, Widal test is still used widely in resource limited settings. Recently, user-friendly rapid immunochromatographic tests (ICT) have been introduced for quick diagnosis of enteric fever. So, we evaluated sensitivity and specificity of an immunochromatography based Salmonella Typhi IgM/IgG test kit and Widal test compared to blood culture for the diagnosis of enteric fever. Method: The study was conducted in the Department of Microbiology, Ibrahim Medical College (IMC) and Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) from June 2017 to September 2017. Clinically suspected enteric fever cases were included. Blood culture, Widal and Salmonella Typhi IgM/IgG detecting ICT were employed for the diagnosis of enteric fever. Results: Out of 71 suspected cases of enteric fever, blood culture was positive in 36 cases (50.7%) while 42 (59.15%) and 35 (49.29%) cases were positive by Widal test and ICT respectively. Widal and ICT had sensitivity and specificity of 100% and 89.9% and 82.9% & 91.4% respectively. Conclusion: Findings of the study suggest that both Widal and immunochromatographic tests can be used interchangeably for rapid diagnosis of enteric fever. Ibrahim Med. Coll. J. 2020; 14(1): 18-25

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 53%

Comparative evaluation of rapid Salmonella Typhi IgM/IgG and Widal test for the diagnosis of enteric fever

Akter¹,

Yeasmin²,

Alam³

et al. 2020

IMC J Med Sci

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“…Similar study from Pakistan was observed where 55.2% were positive by ICT 17 . In contrast to our study, another study from Bangladesh found only 24.7% 18 .…”

Section: Figures In Parenthesis Indicate Percentage (P Value=0000003743 P <005 By Chi-square Test) Discussioncontrasting

confidence: 99%

A comparative study of blood culture and immunochromatographic assay for rapid diagnosis of typhoid fever

Akter¹,

Akter²,

Ahmed

et al. 2020

Bangladesh J Med Microbiol

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Background and objectives: Typhoid fever, caused by Salmonella Typhi, is an important cause of morbidity and mortality in many developing countries including Bangladesh. As early diagnosis of disease and prompt treatment are essential for optimal management, a rapid method is urgently needed. Blood culture is the gold standard for diagnosis of typhoid fever, but it is time consuming. Immunochromatographic test (ICT) is easily accessible, cheap and simple method for diagnosis of typhoid fever, especially in the resource poor countries like Bangladesh. Methodology: 180 samples were collected from suspected typhoid fever cases. This study was conducted to isolate the S. Typhi by blood culture and to detect IgM and IgG antibody to S. Typhi by ICT method. Results: Out of 180 samples, 105(58.33%) were positive in ICT and 24(13.33%) were positive in blood culture. Considering blood culture as gold standard, the sensitivity, specificity, positive predictive value of ICT was 91.67%, 46.79%, 20.95% and 97.33% respectively. Bangladesh J Med Microbiol 2020; 14 (1): 7-10

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Validity of Immunochromatographic Test for Antibody in Diagnosis of Typhoid Fever in Children Admitted in A Tertiary Care Hospital

Cited by 2 publications

References 11 publications

Comparative evaluation of rapid Salmonella Typhi IgM/IgG and Widal test for the diagnosis of enteric fever

Comparative evaluation of rapid Salmonella Typhi IgM/IgG and Widal test for the diagnosis of enteric fever

A comparative study of blood culture and immunochromatographic assay for rapid diagnosis of typhoid fever

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