An abnormal serum sodium level is the most common electrolyte disorder in the United States and can have a significant impact on morbidity and mortality. The direct medical costs of abnormal serum sodium levels are not well understood. The impact of hyponatremia and hypernatremia on 6-mo and 1-yr direct medical costs was examined by analyzing data from the Integrated HealthCare Information Services National Managed Care Benchmark Database. During the period analyzed, there were 1274 patients (0.8%) with hyponatremia (serum sodium Ͻ135 mmol/L), 162,829 (97.3%) with normal serum sodium levels, and 3196 (1.9%) with hypernatremia (Ͼ145 mmol/L). Controlling for age, sex, region, and comorbidities, hyponatremia was a significant independent predictor of costs at 6 mo (41.2% increase in costs; 95% confidence interval, 30.3% to 53.0%) and at 1 yr (45.7% increase; 95% confidence interval, 34.2% to 58.2%). Costs associated with hypernatremia were not significantly different from those incurred by patients with normal serum sodium. In conclusion, hyponatremia is a significant independent predictor of 6-mo and 1-yr direct medical costs. Abnormal serum sodium is the most common electrolyte disorder in the United States. Estimates of the prevalence of hyponatremia range from 1% in general acute care populations 1,2 to 18% among elderly nursing home residents 3 and nearly 30% in intensive care settings. 4 Hypernatremia is less common, ranging from 0.3% to 8.9% in hospitalized adults. 5,6 Mild, chronic hyponatremia is often asymptomatic; neurologic and gastrointestinal symptoms generally increase as the condition worsens. 7 Hypernatremia may also be asymptomatic until it exceeds a certain threshold, at which point central nervous system dysfunction develops. 8 However, hyponatremia and hypernatremia of all severity levels have significant effects on morbidity and mortality.In a cohort of 4123 elderly patients, Terzian et al. 9 studied the relationship between hyponatremia at the time of hospital admission and treatment outcomes. After adjustment for age, sex, length of stay, and several clinical factors, hyponatremia was a significant independent predictor of mortality.Similar results have been found for patients with heart failure and myocardial infarction. In a study of patients with suspected congestive heart failure at admission, serum sodium Յ135 mmol/L was independently associated with major complications during hospitalization, greater length of stay, higher hospital costs, and greater inpatient mortality. 10 In a more recent trial, patients hospitalized for worsening heart failure with hyponatremia at admission (serum sodium Յ135 mmol/L) experienced significantly greater in-hospital and 60-d mortality, compared with patients with normal or high serum sodium. 11 In patients with acute ST-