Validity of four screening scales for major depression in MS

Patten, Scott B.; Burton, Jodie M.; Fiest, Kirsten M.; Wiebe, Samuel; Bulloch, Andrew G. M.; Koch, Marcus; Dobson, Keith S.; Metz, Luanne M.; Maxwell, Colleen J.; Jetté, Nathalie

doi:10.1177/1352458514559297

Cited by 83 publications

(92 citation statements)

References 33 publications

(42 reference statements)

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“…2015) and showed good accuracy for the CES-D, the PHQ (9 and 2), and the HADS. Since the PHQ is available free of charge, it might therefore be particularly interesting.…”

Section: Discussionmentioning

confidence: 94%

“…This approach is, therefore, highly accurate as a screening tool, although a more recent study reported lower estimates of specificity and sensitivity for this instrument (Patten et al. 2015). Moreover, it does not provide a quantitative score of depression severity.…”

Section: Discussionmentioning

confidence: 99%

“…2012; Patten et al. 2015) have used a structured clinical interview to establish MDD diagnosis, and only the most recent ones also included Receiver-Operating characteristics (ROC) analysis, the gold standard to verify diagnostic accuracy. The Hospital Anxiety and Depression Scale (HADS) showed good diagnostic accuracy (Honarmand and Feinstein 2009), however, it only covers some of the diagnostic criteria of MDD.…”

Section: Introductionmentioning

confidence: 99%

“…Finally, a very recent paper demonstrated good accuracy of the patient health questionnaire PHQ-9, the Center for Epidemiologic Studies Depression rating scale (CES-D), and the HADS in MS (Patten et al. 2015). However, there is still paucity of data directly comparing different self-report questionnaires head-to-head and against structured interviews.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic accuracy for major depression in multiple sclerosis using self‐report questionnaires

Fischer

Nicholls

et al. 2015

Brain and Behavior

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ObjectiveMultiple sclerosis and major depressive disorder frequently co-occur but depression often remains undiagnosed in this population. Self-rated depression questionnaires are a good option where clinician-based standardized diagnostics are not feasible. However, there is a paucity of data on diagnostic accuracy of self-report measures for depression in multiple sclerosis (MS). Moreover, head-to-head comparisons of common questionnaires are largely lacking. This could be particularly relevant for high-risk patients with depressive symptoms. Here, we compare the diagnostic accuracy of the Beck Depression Inventory (BDI) and 30-item version of the Inventory of Depressive Symptomatology Self-Rated (IDS-SR30) for major depressive disorder (MSS) against diagnosis by a structured clinical interview.MethodsPatients reporting depressive symptoms completed the BDI, the IDS-SR30 and underwent diagnostic assessment (Mini International Neuropsychiatric Interview, M.I.N.I.). Receiver-Operating Characteristic analyses were performed, providing error estimates and false-positive/negative rates of suggested thresholds.ResultsData from n = 31 MS patients were available. BDI and IDS-SR30 total score were significantly correlated (r = 0.82). The IDS-SR30total score, cognitive subscore, and BDI showed excellent to good accuracy (area under the curve (AUC) 0.86, 0.91, and 0.85, respectively).ConclusionBoth the IDS-SR30 and the BDI are useful to quantify depressive symptoms showing good sensitivity and specificity. The IDS-SR30 cognitive subscale may be useful as a screening tool and to quantify affective/cognitive depressive symptomatology.

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“…2015) and showed good accuracy for the CES-D, the PHQ (9 and 2), and the HADS. Since the PHQ is available free of charge, it might therefore be particularly interesting.…”

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnostic accuracy for major depression in multiple sclerosis using self‐report questionnaires

Fischer

Nicholls

et al. 2015

Brain and Behavior

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“…For depressive symptom severity assessment, the well-known Beck Depression Inventory and the Hospital Anxiety and Depression Scale have both been diagnostically evaluated in MS patients 42,44 and have psychometric properties that are sensitive to change. This sensitivity has, however, not been tested specifically in MS patients.…”

mentioning

confidence: 99%

Fatigue and depression in multiple sclerosis: pharmacological and non-pharmacological interventions

Brenner

Piehl

2016

Acta Neurol Scand

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Multiple sclerosis (MS) is a neuroinflammatory condition with a prominent progressive neurodegenerative facet that typically affects young-or middle-aged adults. Although physical disabilities have been in the foreground by being easier to assess, there is an increasing interest in mental disabilities and psychiatric co-morbidities, which have a disproportionally high impact on important outcome measures such as quality of life and occupational disability. In particular, cognitive impairment, depression and mental fatigue, which mutually interact with each other, seem to be of importance in this context. In recent decades, major efforts have been invested in developing more effective disease modulatory treatments. This has resulted in novel therapeutic options and awareness of the importance of early intervention. In comparison, good quality and adequately powered studies on symptomatic treatments of fatigue and psychiatric co-morbidities in MS are rare, and awareness of treatment options is much lower. We here review the existing evidence base for symptomatic treatment of fatigue and depression in MS patients. With regard to fatigue, off-label prescription of alertness improving drugs is common, in spite of all but absent evidence of efficacy. In contrast, a number of smaller studies suggest that physical exercise and fatigue management courses may have some clinical benefit. Very few studies have addressed the efficacy of antidepressants and non-pharmaceutical interventions specifically in MS patients. Therefore, treatment guidelines largely rely on data from non-MS populations. In the future, there is a strong motive to direct additional resources to the study of these important aspects of MS. K E Y W O R D Scognitive symptoms, depression, fatigue, multiple sclerosis, treatment

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The Relationship between Diet, Depression, and Alzheimer's Disease: A Narrative Review

Al Shamsi,

Rainey‐Smith,

Gardener

et al. 2024

Molecular Nutrition Food Res

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Purpose of ReviewThis narrative review evaluates the role of diet in the relationship between depression and Alzheimer's disease (AD).Recent FindingsAD and depression are often comorbid, and depression appears to independently increase the future risk of AD. Evidence suggests diet influences the risk of both conditions directly and indirectly. Diet impacts neurochemical and biological processes that may affect the development and progression of depression and cognitive dysfunction. The dietary components offering the greatest protection against depression and AD are yet to be determined. Current evidence highlights the importance of polyphenolic compounds, folate, B vitamins, and polyunsaturated fatty acids, along with adherence to dietary patterns like the Mediterranean diet, which includes multiple beneficial dietary factors.SummaryThe investigation of dietary factors in the prevention of depression and AD is a comparatively young field of research. Comprehensive highly characterised longitudinal datasets and advanced analytical approaches are required to further examine the complex relationship between diet, depression, and AD. There is a critical need for more research in this area to develop effective preventive strategies aimed at maintaining mental and physical health with advancing age.

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Validity of four screening scales for major depression in MS

Abstract: While all of the scales performed well in terms of their sensitivity and specificity, the availability of the PHQ-9 in the public domain and its brevity may enhance the feasibility of its use.

Cited by 83 publications

References 33 publications

Diagnostic accuracy for major depression in multiple sclerosis using self‐report questionnaires

Diagnostic accuracy for major depression in multiple sclerosis using self‐report questionnaires

Fatigue and depression in multiple sclerosis: pharmacological and non-pharmacological interventions

The Relationship between Diet, Depression, and Alzheimer's Disease: A Narrative Review

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