Validity of fine needle aspiration cytology in diagnosing thyroid gland neoplasms

Priyani, A. A. H.; Ileperuma, A.; Fernando, Ruchira

doi:10.4038/jdp.v6i1.4424

Cited by 4 publications

(4 citation statements)

References 9 publications

(12 reference statements)

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“…Therefore our findings (31-40 years age group) are within the findings of the international studies (Table 4). There is a wide variation in the global statistics relating to validity of FNAC as a tool for diagnosing thyroid pathology and the Royal College of pathologists (RCPAAustralasia) has allowed a wide range for sensitivity, specificity of FNAC with regard to thyroid neoplasms [13,14]. The sensitivity, specificity and accuracy for diagnosis of neoplasm by FNAC in our study are acceptable.…”

Section: Discussionmentioning

confidence: 53%

Untitled

2017

ICPJL

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Introduction: Pathologies of the thyroid nodules are a common clinical problem in Sri Lanka. Clinical assessment, biochemical investigations, ultrasonography, Fine needle aspiration cytology (FNAC) and histology are used in their diagnosis. However, histology continues to remain as the gold standard. Accurate diagnoses of thyroid nodules are important in planning management and could result in major catastrophes if diagnosis is incorrect. Objectives:To determine the ability of FNAC and ultrasonography (USS) independently and in combination to distinguish neoplastic nodules of thyroid from non-neoplastic nodules.Methodology: A retrospective cross sectional study involving 73 patients from base hospital Embilipitiya, from 2009 January to 2013December was carried out.Results: Study population was female predominant 70(95.9%) with their age ranging from 17-70 (mean 42.7). Sensitivity, specificity, positive predictive value, negative predictive value and accuracy for FNAC were 94.1%, 87.2%, 86.5%, 94.4%, and 90.4% respectively. The corresponding values for ultrasonography were 64.7%, 69.2%, 64.7%, 69.2% and 67.1% respectively. Conclusion:The findings of this study are in keeping with the other studies of this country and the region. In addition FNAC has a higher validity than USS in detection of thyroid neoplasms.

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Section: Discussionmentioning

confidence: 53%

Untitled

2017

ICPJL

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“…T-FNAC, in addition to having a high negative predictive value is documented to have a sensitivity and specificity ranging from 77.7%-93% and 67%-100% respectively (4)(5)(6)(7)(8).…”

Section: Resultsmentioning

confidence: 99%

“…It is important to differentiate neoplastic from non neoplastic thyroid enlargement, to provide optimum healthcare to affected patients. Thyroid fine needle aspiration cytology (T-FNAC) is a widely accepted diagnostic tool for preoperative assessment of solitary thyroid nodules, diffuse and multi-nodular goiters with specificity ranging between 67%-100% and sensitivity ranging between 77.7%-93% (4)(5)(6)(7)(8). T-FNAC diagnostic value is enhanced when combined with radiological investigations and thyroid function assays (6).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic terminology for reporting thyroid cytology: Inter-observer agreement between the format currently used in Sri Lanka and the Bethesda system

2014

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Background: Thyroid cytology reporting has become standardized with the introduction of the Bethesda System of Reporting Thyroid Cytology (BSRTC), linking up diagnostic categories with clinical management guidelines. The current thyroid cytology reporting format in Sri Lanka (TCRSL) is based on the original 'Thy' classification of the British Thyroid Association. The number of diagnostic categories have been increased in the BSRTC than in TCRSL (6 vs. 5 categories), with a possible adverse impact on inter-observer agreement (IOA). IOA of both reporting formats were thus compared to evaluate the appropriateness of looking beyond TCRSL in Sri Lanka, a country facing a significant thyroid cytology burden.Objective: To compare inter-observer agreement between the thyroid cytology reporting format in Sri Lanka and the Bethesda format. Methods: 100 thyroid aspiratesRetrieved smears were reviewed and classified using TCRSL and BSRTC by two pathologists independently. Results were tabulated using SPSS. Linear weighted κ and composite proportion of agreement values were used to evaluate the IOA of responses in both formats. Results:Linear weighted κ was 0.6138 (95% C.I. 0.4797 -0.7479) and the composite proportion of agreement was 68% for TCRSL. In BSRTC, linear weighted κ was 0.6795 (95% C.I. 0.563 -0.796) and the composite proportion of agreement was 70%.Conclusion: IOA for both reporting formats is in the substantial agreement range, with no significant difference in κ values. BSRTC shows a slightly higher composite proportion of agreement than TCRSL. Thus increased diagnostic categories of BSRTC have no significant adverse impact on the IOA in our setting.(

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“…FNAC of the thyroid sensitivity ranges from 77-93% and the specificity ranging between 67-100 %. (3)(4)(5). Matara District has a population of 831 000 (6).…”

Section: Introductionmentioning

confidence: 99%

Spectrum of Thyroid Disease reported to Department of Pathology District General Hospital Matara

Senarath¹,

Wickramasinghe²

2015

J. Ruhunu Clin. Soc.

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Objectives: This study aimed to characterize the cyto pathological and histopathological pattern of thyroid lesions and to highlight the age and gender variations of these lesions. Materials and Methods:We retrospectively analyzed the data from thyroid specimens including FNAC and the surgical pathology samples received at the Department of Pathology, District General Hospital Matara from June 2014 to January 2015.Results: The 1000 specimens, 929 FNAC and 71 thyroidectomy specimens received during the study period came from (95.69%) 887 females and (4.31%) 40 males in FNAC specimens and from (92.95%) 66 females and (7.05%) 05 males. Age of the patients ranged from 04 years to 92 years. 904 (97.3%) cases were found to be non-neoplastic and 25 (2.7%) cases were neoplastic in FNAC and 34 (47.88%) cases were found to be non-neoplastic and 21 (29.57%) cases benign and 16 (22.53%) were malignant lesions in thyroidectomy specimens. The non-neoplastic group in FNAC included: colloid goiter, including both diffuse and nodular goiter (395 cases; 42.5%), colloid cyst (107 cases; 11.5 %) and Hashimoto/chronic lymphocytic thyroiditis (244 cases; 26.6%). In neoplastic lesions in thyroidectomies, there were benign tumors and malignant tumors. Among the benign tumors, 20 were follicular adenomas and 01 was a Hurthle cell adenomas. Papillary carcinoma was the commonest malignant tumor accounting for 50% of all thyroid malignancies, followed by, papillary micro carcinoma (25%) and follicular carcinoma (12.5%).Conclusions: Non-neoplastic thyroid lesions were more common than neoplastic ones. Colloid goiter was the most common lesion. Follicular adenoma was the commonest benign tumor and papillary carcinoma was the commonest malignant lesion.

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Validity of fine needle aspiration cytology in diagnosing thyroid gland neoplasms

Cited by 4 publications

References 9 publications

Untitled

Untitled

Diagnostic terminology for reporting thyroid cytology: Inter-observer agreement between the format currently used in Sri Lanka and the Bethesda system

Spectrum of Thyroid Disease reported to Department of Pathology District General Hospital Matara

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