Validity of arterialized earlobe blood gases at rest and exercise in normoxia and hypoxia

Mollard, Pascal; Bourdillon, Nicolas; Letournel, Muriel; Herman, Harold; Gibert, Stéphanie; Pichon, Aurélien; Woorons, Xavier; Richalet, Jean‐Paul

doi:10.1016/j.resp.2010.05.017

Cited by 30 publications

(21 citation statements)

References 21 publications

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“…This is in agreement with the statement of Powers et al (1988) that exercise induced hypoxemia is highly reproducible among highly trained endurance athletes who show a marked decline in SaO2 during heavy exercise. The validity of a pulse oximiter similar to the one used in our study was R 2 = 0.90 with a mean error = 0.3% (compared to the reference method, i.e., cooximetry in the arterial blood) (Mollard et al 2010;Yamaya et al 2002).…”

Section: Anthropometry Physiology and Arterial Oxygen Saturationmentioning

confidence: 53%

The effect of exercise-induced hypoxemia on blood redox status in well-trained rowers

et al. 2011

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Exercise-induced arterial hypoxemia (EIAH), characterized by decline in arterial oxyhemoglobin saturation (SaO(2)), is a common phenomenon in endurance athletes. Acute intensive exercise is associated with the generation of reactive species that may result in redox status disturbances and oxidation of cell macromolecules. The purpose of the present study was to investigate whether EIAH augments oxidative stress as determined in blood plasma and erythrocytes in well-trained male rowers after a 2,000-m rowing ergometer race. Initially, athletes were assigned into either the normoxemic (n = 9, SaO(2) >92%, [Formula: see text]: 62.0 ± 1.9 ml kg(-1) min(-1)) or hypoxemic (n = 12, SaO(2) <92%, [Formula: see text]: 60.5 ± 2.2 ml kg(-1 )min(-1), mean ± SEM) group, following an incremental [Formula: see text] test on a wind resistance braked rowing ergometer. On a separate day the rowers performed a 2,000-m all-out effort on the same rowing ergometer. Following an overnight fast, blood samples were drawn from an antecubital vein before and immediately after the termination of the 2,000-m all-out effort and analyzed for selective oxidative stress markers. In both the normoxemic (SaO(2): 94.1 ± 0.9%) and hypoxemic (SaO(2): 88.6 ± 2.4%) rowers similar and significant exercise increase in serum thiobarbituric acid-reactive substances, protein carbonyls, catalase and total antioxidant capacity concentration were observed post-2,000 m all-out effort. Exercise significantly increased the oxidized glutathione concentration and decreased the ratio of reduced (GSH)-to-oxidized (GSSG) glutathione in the normoxemic group only, whereas the reduced form of glutathione remained unaffected in either groups. The increased oxidation of GSH to GSSG in erythrocytes of normoxemic individuals suggest that erythrocyte redox status may be affected by the oxygen saturation degree of hemoglobin. Our findings indicate that exercise-induced hypoxemia did not further affect the increased blood oxidative damage of lipids and proteins observed after a 2,000-m rowing ergometer race in highly-trained male rowers. The present data do not support any potential link between exercise-induced hypoxemia, oxidative stress increase and exercise performance.

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Section: Anthropometry Physiology and Arterial Oxygen Saturationmentioning

confidence: 53%

The effect of exercise-induced hypoxemia on blood redox status in well-trained rowers

et al. 2011

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“…Pulse oximetry method has been reported to deliver high precision, reproducibility and validity for O 2 saturation above 75% when compared to O 2 saturation measured from arterial blood gases at rest and exercise, at SL and at ALT [16,17]. Mollard et al [17] have shown that the correlation between SaO 2 and SpO 2 was strong (r 2 = 0.97, p < 0.001). In our study we are in agreement with the literature because SpO 2 values were > 75%.…”

Section: Discussionmentioning

confidence: 99%

Exercise-Induced Hypoxaemia Developed at Sea-Level Influences Responses to Exercise at Moderate Altitude

et al. 2016

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PurposeThe aim of this study was to investigate the impact of exercise-induced hypoxaemia (EIH) developed at sea-level on exercise responses at moderate acute altitude.MethodsTwenty three subjects divided in three groups of individuals: highly trained with EIH (n = 7); highly trained without EIH (n = 8) and untrained participants (n = 8) performed two maximal incremental tests at sea-level and at 2,150 m. Haemoglobin O2 saturation (SpO2), heart rate, oxygen uptake (VO2) and several ventilatory parameters were measured continuously during the tests.ResultsEIH athletes had a drop in SpO2 from 99 ± 0.8% to 91 ± 1.2% from rest to maximal exercise at sea-level, while the other groups did not exhibit a similar decrease. EIH athletes had a greater decrease in VO2max at altitude compared to non-EIH and untrained groups (-22 ± 7.9%, -16 ± 5.3% and -13 ± 9.4%, respectively). At altitude, non-EIH athletes had a similar drop in SpO2 as EIH athletes (13 ± 0.8%) but greater than untrained participants (6 ± 1.0%). EIH athletes showed greater decrease in maximal heart rate than non-EIH athletes at altitude (8 ± 3.3 bpm and 5 ± 2.9 bpm, respectively).ConclusionEIH athletes demonstrated specific cardiorespiratory response to exercise at moderate altitude compared to non-EIH athletes with a higher decrease in VO2max certainly due to the lower ventilator and HRmax responses. Thus EIH phenomenon developed at sea-level negatively impact performance and cardiorespiratory responses at acute moderate altitude despite no potentiated O2 desaturation.

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“…Recent arterial blood pH measurements in 221 healthy individuals, tested in several studies, consistently showed an arterial pH of 7.39 or higher, in some cases even up to 7.49 (2,(10)(11)(12). These pH values are higher than reported in most textbooks (4-7).…”

Section: American Thoracicmentioning

confidence: 80%

Is the Reference Arterial pH Higher than Usually Acknowledged?

Berend¹

2011

Am J Respir Crit Care Med

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D, et al. Prednisolone inhibits proliferation of cultured pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension. O, et al. Plateletderived growth factor expression and function in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 2008;178:81-88. 6. Liakopoulos OJ, Teucher N, Muhlfeld C, Middel P, Heusch G, Schoendube FA, Dorge H. Prevention of TNFalpha-associated myocardial dysfunction resulting from cardiopulmonary bypass and cardioplegic arrest by glucocorticoid treatment. Eur J Cardiothorac Surg 2006;30:263-270. 7. Voisard R, Seitzer U, Baur R, Dartsch PC, Osterhues H, Hoher M, Hombach V. Corticosteroid agents inhibit proliferation of smooth muscle cells from human atherosclerotic arteries in vitro. Int J Cardiol 1994;43:257-267. 8. Mariette X, Brenot F, Brouet JC. Recovery from pulmonary hypertension with steroid therapy in a patient with Sjogren's syndrome and polymyositis.

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Validity of arterialized earlobe blood gases at rest and exercise in normoxia and hypoxia

Cited by 30 publications

References 21 publications

The effect of exercise-induced hypoxemia on blood redox status in well-trained rowers

The effect of exercise-induced hypoxemia on blood redox status in well-trained rowers

Exercise-Induced Hypoxaemia Developed at Sea-Level Influences Responses to Exercise at Moderate Altitude

Is the Reference Arterial pH Higher than Usually Acknowledged?

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