Validity of Activity Indices in Ulcerative Colitis: Comparison of Clinical and Endoscopic Indices

Abstract

Our results demonstrated that all the CI and El examined were almost equally useful for evaluating disease activity in UC patients. Further studies may help to determine which of the indices is the most suitable for use in UC clinical trials.

Clinical Parameters Correlate With Endoscopic Activity of Ulcerative Colitis: A Systematic Review

“…Active vs inactive disease. Overall, 8 studies only included patients with active disease (Lewis et al, 19 Dhanda et al, 20 Jharap et al, 21 Scaioli et al, 23 Seo et al, 3 Achitei et al, 24 Mirpour et al, 25 Jairath et al 1 ), whereas 15 studies included patients with both active and inactive disease (Bodelier et al, 26 Schoepfer et al, 27 Pagnini et al, 28 Beattie et al, 7 Azzolini et al, 12 Hirai et al, 29 Langhorst et al, 30 Arai et al, 31 Higging et al, 32 Ricanek et al, 33 Samuel et al, 34 Taleban et al, 35 Falvey et al, 36 Chen et al, 37 and Colombel et al 22 ). Unfortunately, the published data do not provide information for active vs inactive disease separately.…”

“…All of these studies consistently showed a good correlation between noninvasive indices and endoscopy results in studies of active patients only, or in studies with both active patients and patients in remission. However, 2 studies (Pagnini et al 28 and Hirai et al 29 ) suggested that the correlation between clinical and endoscopic indices might be stronger among patients with lower levels of disease activity. For example, in Hirai et al 29 the correlations between the clinical indices and endoscopic indices were weaker (Spearman correlation coefficient, 0.29-0.47) when the disease activity in the UC patients was high, whereas with a decrease in disease activity after treatment, the positive correlations among indices was stronger (Spearman correlation coefficient, 0.53-0.84).…”

The potential of volatile organic compounds for the detection of active disease in patients with ulcerative colitis

“…These indices correlate with endoscopic disease activity, but are prone to inter‐observer variation and may therefore lead to incorrect classification of remission or active disease . The correlation of symptoms with severity of endoscopic lesions was, however, found to be weaker in case of highly active inflammation, when compared to moderate or low level inflammation . Furthermore, functional irritable bowel syndrome‐like symptoms regularly occur in patients with low‐grade inflammation or in the absence of endoscopic inflammation, and affect clinical activity scores.…”

Pharmacologic therapies for severe steroid refractory hospitalized ulcerative colitis: A network meta‐analysis

“…Most of the studies used commonly used indices such as Lichtiger's index, Truelove–Witts score, and disease activity index. These are known to be equally useful to assess disease activity in UC and to correlate well with each other; thus, we expect that there was little variability among studies . Another limitation is the difference of the study duration among studies.…”

“…These are known to be equally useful to assess disease activity in UC and to correlate well with each other; thus, we expect that there was little variability among studies. 41 Another limitation is the difference of the study duration among studies. The duration of most studies were 2-4 weeks; however, two studies had longer periods, which may have influenced the outcome of our results.…”