Validity and usefulness of the RAE-CMBD studying patients hospitalised with influenza

Abstract

Background. Understanding the hospital impact of influenza requires enriching epidemiological surveillance registries with other sources of information. The aim of this study was to determine the validity of the Hospital Care Activity Record – Minimum Basic Data Set (RAE-CMBD) in the analysis of the outcomes of patients hospitalised with this infection. Methods. Observational and retrospective study of adults admitted with influenza in a tertiary hospital during the 2017/2018 and 2018/2019 seasons. We calculated the concordance of the RAE-CMBD with the influenza epidemiological surveillance registry (gold standard), as well as the main parameters of internal and external validity. Logistic regression models were used for risk adjustment of in-hospital mortality and length of stay. Results. A total of 907 (97.74%) unique matches were achieved, with high inter-observer agreement (ƙ=0.828). The RAE-CMBD showed a 79.87% sensitivity, 99.72% specificity, 86.71% positive predictive value and 99.54% negative predictive value. The risk-adjusted mortality ratio of patients with influenza was lower than that of patients without influenza: 0.667 (0.53-0.82) vs. 1.008 (0.98-1.04) and the risk-adjusted length of stay ratio was higher: 1.15 (1.12-1.18) vs. 1.00 (0.996-1.001). Conclusion. The RAE-CMBD is a valid source of information for the study of the impact of influenza on hospital care. The lower risk-adjusted mortality of patients admitted with influenza compared to other inpatients seems to point to the effectiveness of the main clinical and organisational measures adopted

Impact of influenza related hospitalization in Spain: characteristics and risk factor of mortality during five influenza seasons (2016 to 2021)

“…However, we considered that our definition of influenza hospitalization was very specific, as we assumed that the attribution of an ICD-10 influenza code relies on a viral confirmation test as per guideline recommendations. However, the SNSSHD used in this study, which has been validated for influenza infection in Spain ( 31 ), showed 79.87% sensitivity, 99.72% specificity, 86.71% positive predictive value and 99.54% negative predictive.…”

Estimated Respiratory Syncytial Virus-Related Hospitalizations and Deaths Among Children and Adults in Spain, 2016–2019

“…We obtained anonymized individual-level data on daily hospitalizations from the Ministry of Health’s national hospital discharge database (“Conjunto Mínimo Básico de Datos”, CMBD) that reports more than 90% of all admissions in both public and private institutions [ 35 ] and has been validated for data quality [ 36 , 37 ]; and mortality data from the National Statistical Office’s mortality database (“Base de datos de mortalidad del Instituto Nacional de Estadística”, BDM) that reports 100% of deaths [ 38 ] between 2016 and 2019. All diagnoses were coded according to the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) [ 39 ].…”