Validity and test-retest reliability of a disability questionnaire for essential tremor

Louis, Elan D.; Barnes, Livia F.; Wendt, Kristin J.; Albert, Steven; Pullman, Seth L.; Yu, Qiping; Schneier, Franklin R.

doi:10.1002/1531-8257(200005)15:3<516::aid-mds1015>3.0.co;2-j

Cited by 71 publications

(57 citation statements)

References 40 publications

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“…While the presence FXTAS was not an exclusionary criteria, none of the women reported a clinical diagnosis of FXTAS. The groups did not differ in self-reported functional symptoms of tremor measured with the Tremor Disability Questionnaire [109], p = 0.508. Information on menopause status was also collected from the women with the FMR1 premutation, as autonomic changes are observed among postmenopausal women (e.g., [110]) and the FMR1 premutation is linked with early menopause [111].…”

Section: Methodsmentioning

confidence: 99%

Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety

Klusek

LaFauci

Adayev

et al. 2017

J Neurodevelop Disord

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BackgroundAutonomic dysfunction is implicated in a range of psychological conditions, including depression and anxiety. The fragile X mental retardation-1 (FMR1) premutation is a common genetic mutation that affects ~1:150 women and is associated with psychological vulnerability. This study examined cardiac indicators of autonomic function among women with the FMR1 premutation and control women as potential biomarkers for psychological risk that may be linked to FMR1.MethodsBaseline inter-beat interval and respiratory sinus arrhythmia (a measure of parasympathetic vagal tone) were measured in 35 women with the FMR1 premutation and 28 controls. The women completed anxiety and depression questionnaires. FMR1 genetic indices (i.e., CGG repeat, quantitative FMRP, FMR1 mRNA, activation ratio) were obtained for the premutation group.ResultsRespiratory sinus arrhythmia was reduced in the FMR1 premutation group relative to controls. While depression symptoms were associated with reduced respiratory sinus arrhythmia among control women, these variables were unrelated in the FMR1 premutation. Elevated FMR1 mRNA was associated with higher respiratory sinus arrhythmia.ConclusionsWomen with the FMR1 premutation demonstrated autonomic dysregulation characterized by reduced vagal tone. Unlike patterns observed in the general population and in study controls, vagal activity and depression symptoms were decoupled in women with the FMR1 premutation, suggesting independence between autonomic regulation and psychopathological symptoms that is atypical and potentially specific to the FMR1 premutation. The association between vagal tone and mRNA suggests that molecular variation associated with FMR1 plays a role in autonomic regulation.

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Section: Methodsmentioning

confidence: 99%

Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety

Klusek

LaFauci

Adayev

et al. 2017

J Neurodevelop Disord

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“…Results and Discussion Mean symptom severity score was 42.8 (SD=19.7), similar to the validation samples 7 . Mean embarrassment score was 42.5 (SD=11.5), a higher level than that obtained in the validation sample, which may be partially explained by the higher number of younger adults in the present sample 3 .…”

Section: Methodsmentioning

confidence: 99%

“…The respondents were from North America (46%), the UK (20%) and mainland Europe (34%). The mean age was 49y (SD=13y), and the mean age of onset was 21y (SD=16.4y), thus yielding a sample biased towards younger participants with childhood onset, relative to clinic-based samples 7 . The study was given ethical approval by Lancaster University Ethics Committee, and online informed consent was obtained from participants.…”

Section: Introductionmentioning

confidence: 99%

Relations between psychological avoidance, symptom severity and embarrassment in essential tremor

Holding

Lew

2014

Chronic Illness

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Research with community-and clinic-based samples of essential tremor (ET) sufferers has identified embarrassment as a common consequence of the condition, leading to social anxiety and avoidance. We sought to ascertain whether psychological avoidance was related to embarrassment in ET, and whether any such relation was independent of symptom severity. Establishing whether psychological avoidance is related to embarrassment in ET would be a first indicator that mindfulness-based therapeutic approaches may be appropriate for sufferers of ET. Ninety-two participants were recruited through online support groups run by the International Tremor Foundation and the UK National Tremor Foundation, with the self-reported inclusion criteria being a clinical diagnosis of ET. Participants completed 3 validated questionnaires concerning ET-related embarrassment, ET symptom severity and psychological avoidance. Females had slightly higher embarrassment scores than males, and symptom severity and psychological avoidance made significant moderate (each accounting for 10-15% of variance approx.), but independent contributions to embarrassment scores. These results suggest that to address the potentially debilitating effects of embarrassment in ET, both symptom severity and psychological avoidance need to be targeted, with intervention research being required.

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“…Furthermore, previous studies have used spiral drawing as a qualitative neurological assessment tool for the assessment and understanding of motor control disorders such as PD. [12][13][14][15][16][17][18] However there is a paucity of empirical studies designed to elucidate the mechanisms involved in the task. Past research indicates that a healthy person who does not display signs of motor dysfunction and who can perform this task with a high degree of accuracy will produce "smooth" curves when drawing a spiral.…”

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confidence: 99%

Discrete and dynamic scaling of the size of continuous graphic movements of parkinsonian patients and elderly controls

Longstaff

2003

Journal of Neurology, Neurosurgery &Amp; Psychiatry

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Validity and test-retest reliability of a disability questionnaire for essential tremor

Cited by 71 publications

References 40 publications

Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety

Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety

Relations between psychological avoidance, symptom severity and embarrassment in essential tremor

Discrete and dynamic scaling of the size of continuous graphic movements of parkinsonian patients and elderly controls

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