Validity and Reliability of the Japanese Version of the Rome III Diagnostic Questionnaire for Irritable Bowel Syndrome and Functional Dyspepsia

Kanazawa, Motoyori; Nakajima, Shigenori; Oshima, Tadayuki; Sperber, Ami D.; Palsson, Olafur S.; Drossman, Douglas A.; Miwa, Hiroto; Fukudo, Shin

doi:10.5056/jnm15016

Cited by 39 publications

(45 citation statements)

References 20 publications

(28 reference statements)

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“…We also found that the positive endoscopic and ultrasonographic findings in patients diagnosed using the questionnaire varied with the location of disease. More positive findings were observed in patients with functional esophageal and gastroduodenal disorders than in those with functional bowel disorders, which is consistent with the results of other studies . There are several possible reasons for this finding.…”

Section: Discussionsupporting

confidence: 92%

“…This study suggests that the symptom‐based questionnaire is important for diagnosing FGID, especially for screening patients. Many studies have focused on validating the Rome III questionnaire, but its diagnostic accuracy varies in different populations and regions . The patients included in our study consisted of patients without red flag symptoms and those without a history of disease that could induce the GI symptoms.…”

Section: Discussionmentioning

confidence: 99%

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Positive endoscopic and ultrasonographic findings in patients with symptom‐diagnosed functional gastrointestinal disorder: Data from a Chinese cross‐sectional study

Bai

Wang

Zhang

et al. 2018

J of Digest Diseases

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Objective Few studies have systematically assessed symptom‐based diagnoses of functional gastrointestinal disorders (FGID) in China. This study aimed to evaluate the positive endoscopic and ultrasonographic findings in patients with symptom‐based FGID. Methods Adult patients with gastrointestinal symptoms but not red flag symptoms who were empirically diagnosed with FGID underwent an upper or lower gastrointestinal endoscopy. An abdominal ultrasonography was also performed to screen for potential organic diseases. Patients’ data were collected and the Rome III questionnaire was used for symptom‐based assessment. Results Positive endoscopic and ultrasonographic findings were detected in 31.8%, 26.2% and 9.9% of patients with esophageal, gastroduodenal and intestinal disorders, respectively. Among patients diagnosed with FGID using the questionnaire, the rates of positive endoscopic and ultrasonographic findings were higher in patients with upper gastrointestinal symptoms than in those with lower gastrointestinal symptoms. Moreover, patients elder than 34.5 years with upper gastrointestinal symptoms and those elder than 47.5 years with lower gastrointestinal symptoms were more likely to have positive endoscopic and ultrasonographic findings. Conclusions The Rome III questionnaire is a valuable diagnostic tool for screening FGID in China. However, the rates of positive endoscopic and ultrasonographic findings vary depending on the location of symptoms. Endoscopy and ultrasonography have irreplaceable value, especially for investigating upper gastrointestinal symptoms.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Positive endoscopic and ultrasonographic findings in patients with symptom‐diagnosed functional gastrointestinal disorder: Data from a Chinese cross‐sectional study

Bai

Wang

Zhang

et al. 2018

J of Digest Diseases

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“…Sex, age, and rates of H pylori infection did not differ between the patients with FD and the controls (Table ). Among the 35 patients with confirmed FD, 25 had postprandial distress syndrome and 10 had the unclassified type …”

Section: Resultsmentioning

confidence: 99%

Duodenal low‐grade inflammation and expression of tight junction proteins in functional dyspepsia

Taki

Oshima

et al. 2019

Neurogastroenterology Motil

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Background Duodenal changes in functional dyspepsia (FD) might be related to the development of symptoms. However, relationships among low‐grade inflammation, Helicobacter pylori infection, and protein expression by tight junctions (TJs) in the duodenum are unclear. We therefore aimed to determine whether duodenal inflammation and genes associated with TJ proteins are associated with FD. Methods We evaluated inflammatory cell infiltration of the duodenum, H pylori infection, and genes associated with TJ proteins in duodenal biopsy specimens from 35 patients with FD according to the Rome III diagnostic questionnaire and from 31 asymptomatic controls without structural diseases. We immunohistochemically detected eosinophils and mast cells and counted them. The expression of claudins, occludin, and zonula occludens (ZO)‐1 mRNA was evaluated using quantitative RT‐PCR. Infection with H pylori was determined by measuring serum antibodies, rapid urease or urea breath tests, and endoscopic findings. Results Sex, age, and H pyloriinfection rates did not differ between patients with FD and controls. The numbers of eosinophils and mast cells were significantly increased in patients with FD compared with controls and were significantly correlated. Inflammatory cell counts in the duodenum were not associated with H pylori infection status. Claudin‐3 mRNA expression was increased in the patients with FD. Conclusions Subtle inflammation identified in the duodenum of patients with FD might be associated with the onset and persistence of dyspeptic symptoms.

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“…18 The questionnaire was composed of 13 items regarding defecation habits and actual status. The questionnaire items are shown in the Appendix.…”

Section: Questionnaire Itemsmentioning

confidence: 99%

Prevalence and Self-recognition of Chronic Constipation: Results of an Internet Survey

Tamura

Tomita

Oshima

et al. 2016

J Neurogastroenterol Motil

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Background/AimsAlthough chronic constipation is a common symptom, to date no international consensus has been reached regarding its definition. The aims of this study were (1) to investigate defecation habits and (2) to examine the prevalence of constipation using the Japanese Society of Internal Medicine (JSIM) and the Rome III criteria using an online survey. MethodsAn online questionnaire composed of items on the frequency, interval, form of defecation, the management, and self-recognition of constipation (reference standard of constipation) was created. A total of 5155 valid responses were received. In addition, constipation symptoms were evaluated through a survey using the JSIM and the Rome III criteria. ResultsIn the internet survey, 28.4% of the respondents considered themselves to be constipated. Stratified by sex, significantly more females (37.5%) than males (19.1%) considered themselves to be constipated (P < 0.001). The prevalence of constipation among the respondents was 28.0% using the Rome III, but only 10.1% using the JSIM. The diagnostic accuracy was 73.2% for the Rome III and 78.1% for the JSIM, while the diagnostic specificity was 81.1% for the Rome III and 97.5% for the JSIM. However, the diagnostic sensitivities for both measures were low, at 52.2% and 29.2% for the Rome III and the JSIM, respectively. ConclusionsThe online survey developed for this study was able to provide clarification regarding defecation patterns. The results also suggest a discrepancy between the self-recognized prevalence of constipation in Japan and prevalence of constipation based on the JSIM criteria. (J Neurogastroenterol Motil 2016;22:677-685)

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Validity and Reliability of the Japanese Version of the Rome III Diagnostic Questionnaire for Irritable Bowel Syndrome and Functional Dyspepsia

Cited by 39 publications

References 20 publications

Positive endoscopic and ultrasonographic findings in patients with symptom‐diagnosed functional gastrointestinal disorder: Data from a Chinese cross‐sectional study

Positive endoscopic and ultrasonographic findings in patients with symptom‐diagnosed functional gastrointestinal disorder: Data from a Chinese cross‐sectional study

Duodenal low‐grade inflammation and expression of tight junction proteins in functional dyspepsia

Prevalence and Self-recognition of Chronic Constipation: Results of an Internet Survey

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