OBJECTIVES:To determine the effectiveness of a proactive primary care program on the daily functioning of older people in primary care. DESIGN: Single-blind, three-arm, cluster-randomized controlled trial with 1-year follow-up. SETTING: Primary care setting, 39 general practices in the Netherlands. PARTICIPANTS: Community-dwelling people aged 60 and older (N = 3,092). INTERVENTIONS: A frailty screening intervention using routine electronic medical record data to identify older people at risk of adverse events followed by usual care from a general practitioner; after the screening intervention, a nurse-led care program consisting of a comprehensive geriatric assessment, evidence-based care planning, care coordination, and follow-up; usual care. MEASUREMENTS: Primary outcome was daily functioning measured using the Katz-15 (6 activities of daily living (ADLs), 8 instrumental activities of daily living (IADLs), one mobility item (range 0-15)); higher scores indicate greater dependence. Secondary outcomes included quality of life, primary care consultations, hospital admissions, emergency department visits, nursing home admissions, and mortality. RESULTS: The participants in both intervention arms had less decline in daily functioning than those in the usual care arm at 12 months (mean Katz-15 score: screening arm, 1.87, 95% confidence interval (CI) = 1.77-1.97; screening and nurse-led care arm, 1.88, 95% CI = 1.80-1.96; control group, 2.03, 95% CI = 1.92-2.13; P = .03). No differences in quality of life were observed. CONCLUSION: Participants in both intervention groups had less decline than those in the control group at 1-year follow-up. Despite the statistically significant effect, the clinical relevance is uncertain at this point because of the small differences. Greater customizing of the intervention combined with prolonged follow-up may lead to morerobust results. J Am Geriatr Soc 64:1779-1788, 2016.Key words: primary care; daily functioning; randomized controlled trial; older people; nurse-led care program P roviding optimal care for the increasing number of older people with complex care needs is a major challenge in primary care. 1,2 The average primary care consultation rate for Dutch citizens increases from 4.3 to 6.2 per year between the ages of 60 and 75 to 10 or more per year after the age of 75. 3 The current approach in primary care is reactive and fragmented and does not meet the needs of older people as they experience a lack of overview and coordination when multiple care providers are involved. 4 These deficits result in unnecessary losses of daily functioning, suboptimal quality of life, and high healthcare expenditures. 5 A transition toward more-proactive primary care that focuses on maintaining independence and prevention of functional decline in older adults has been proposed, 6 but the critical components of a more-proactive primary care system remain unknown.The literature regarding the prevention of functional decline in older adults suggests a stepwise identification of people who are a...