Validity and reliability of the newly translated Hellenic Neuropsychiatric Inventory (H‐NPI) applied to Greek outpatients with Alzheimer's disease: a study of disturbing behaviors among referrals to a memory clinic

Politis, Antonis; Mayer, Lawrence S.; Passa, Maria; Maillis, Antonis; Lyketsos, Constantine G.

doi:10.1002/gps.1045

Cited by 93 publications

(73 citation statements)

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“…The least common domains, namely euphoria, aberrant motor behavior, disinhibition and hallucinations, were similar to those found in previous studies [39, 42, 43]. In fact, neuropsychiatric symptoms are ubiquitous in nursing home demented patients, with prevalence rates above 80% [47] and the institutionalization must be taken into account as an important environmental factor.…”

Section: Discussionsupporting

confidence: 86%

“…This can be explained in part by the fact that some of these studies included only patients with dementia [39, 40, 42] with the correlated potential for referral bias leading to higher frequency estimates in contrast with the present study that addressed both demented and healthy subjects which can explain the minor prevalence of this particular BPSD. On the other hand, clinicians often regard depression as a model for defining apathy, even if these concepts have to be distinguished.…”

Section: Discussionmentioning

confidence: 64%

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Validity and Reliability of the European Portuguese Version of Neuropsychiatric Inventory in an Institutionalized Sample

et al. 2015

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BackgroundNeuropsychiatric symptoms are very common in dementia and have been associated with patient and caregiver distress, increased risk of institutionalization and higher costs of care. In this context, the neuropsychiatric inventory (NPI) is the most widely used comprehensive tool designed to measure neuropsychiatric Symptoms in geriatric patients with dementia. The aim of this study was to present the validity and reliability of the European Portuguese version of NPI.MethodsA cross-sectional study was carried out with a convenience sample of institutionalized patients (≥ 50 years old) in three nursing homes in Portugal. All patients were also assessed with mini-mental state examination (MMSE) (cognition), geriatric depression scale (GDS) (depression) and adults and older adults functional assessment inventory (IAFAI) (functionality). NPI was administered to a formal caregiver, usually from the clinical staff. Inter-rater and test-retest reliability were assessed in a subsample of 25 randomly selected subjects.ResultsThe sample included 166 elderly, with a mean age of 80.9 (standard deviation: 10.2) years. Three out of the NPI behavioral items had negative correlations with MMSE: delusions (rs = -0.177, P = 0.024), disinhibition (rs = -0.174, P = 0.026) and aberrant motor activity (rs = -0.182, P = 0.020). The NPI subsection of depression/dysphoria correlated positively with GDS total score (rs = 0.166, P = 0.038). NPI showed good internal consistency (overall α = 0.766; frequency α = 0.737; severity α = 0.734). The inter-rater reliability was excellent (intraclass correlation coefficient (ICC): 1.00, 95% confidence interval (CI) 1.00 - 1.00), as well as test-retest reliability (ICC: 0.91, 95% CI 0.80 - 0.96).ConclusionThe results found for convergent validity, inter-rater and test-retest reliability, showed that this version appears to be a valid and reliable instrument for evaluation of neuropsychiatric symptoms in institutionalized elderly.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 64%

Validity and Reliability of the European Portuguese Version of Neuropsychiatric Inventory in an Institutionalized Sample

et al. 2015

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“…Psychotic symptoms were assessed with the Neuropsychiatric Inventory (NPI) (Cummings et al, 1994). The Greek version (H-NPI) was validated in a recent study using a part of the present sample (Politis et al, 2004). Depressive manifestations were assessed with the Cornell Scale for Depression in Dementia (CDDS) (Alexopoulos et al, 1988).…”

Section: Sample and Clinical Evaluationmentioning

confidence: 99%

APOE epsilon‐4 allele and cytokine production in Alzheimer's disease

Olgiati

Politis

Malitas³

et al. 2009

Int J Geriat Psychiatry

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These preliminary findings suggest the involvement of inflammatory response in the pathogenic effect of the APOE epsilon-4 allele in AD, although their replication in larger samples is mandatory. The modest correlations between pro-inflammatory cytokines released at peripheral level and AD features emphasizes the need for further research to elucidate the role of neuroinflammation in pathophysiology of AD.

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“…It is relatively brief comprising in its original version 10 symptoms/ behavioural disturbances and in a later expanded version it comprises 12 items. It possesses satisfactory psychometric properties in the original English version (6) as well as in other languages (7), but so far has not been assessed in a Danish version.…”

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confidence: 98%

The Neuropsychiatric Inventory—NPI. Validation of the Danish version

Kørner¹,

Lauritzen²,

Lolk

et al. 2008

Nordic Journal of Psychiatry

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Assessment of neuropsychiatric symptoms in dementia has great clinical importance. The aim of the study was validation of the Danish version of the NPI, using assessments of 72 demented and 29 non-demented of age 65+ years and their caregivers at three visits. The NPI was administered by the same psychiatric nurse interviewing the same caregiver. At visits 1 and 3, a psychogeriatrician assessed the participant using the ICD-10, the Geriatric Deterioration Scale (GDS) and the Clinical Global Impression (CGI) as well as the NPI in a visual analogue scale (VAS) version. These scores were blindly converted into scores equalling the frequency and severity of the NPI by one of the investigators. Data analysis comprised inter-rater reliabilities (intra-class coefficients, ICC); NPI scores and corresponding VAS scores were compared using Spearman's correlation coefficients. NPI scores at visits 1 and 2 were used to assess the test-retest reliabilities. The scalability of the NPI was assessed with Mokken and Loevinger coefficients. The ICC for all the NPI domains and the GDS (>0.80) were perfect, the ICC for the NPI-VAS (0.68-0.95) and the CGI (0.69) was satisfactory to perfect. Correlations between NPI and NPI-VAS were high; only two domains had coefficients below 0.60: depression and agitation/aggression. NPI-total scores increase with increasing severity of dementia. The NPI did not fulfil the scalability assessed by the Mokken and Loevinger coefficients. The NPI Danish version is valid and reliable in assessing neuropsychiatric symptoms in dementia but not fully scalable. The use of single item scores and not total sum score is recommended.

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Validity and reliability of the newly translated Hellenic Neuropsychiatric Inventory (H‐NPI) applied to Greek outpatients with Alzheimer's disease: a study of disturbing behaviors among referrals to a memory clinic

Abstract: These results indicate that the H-NPI is a reliable instrument, able to detect differences in clinically referred groups of AD patients.

Cited by 93 publications

References 22 publications

Validity and Reliability of the European Portuguese Version of Neuropsychiatric Inventory in an Institutionalized Sample

Validity and Reliability of the European Portuguese Version of Neuropsychiatric Inventory in an Institutionalized Sample

APOE epsilon‐4 allele and cytokine production in Alzheimer's disease

The Neuropsychiatric Inventory—NPI. Validation of the Danish version

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