Validity and reliability measures of the Swedish Karolinska version of the Edinburgh Cognitive and Behavioral ALS Screen (SK-ECAS)

Foucher, Juliette; Winroth, Ivar; Lovik, Anikó; Sennfält, Stefan; Pereira, Joana B.; Fang, Fang; Lulé, Dorothée; Andersen, Peter M.; Ingre, Caroline

doi:10.1080/21678421.2023.2239857

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

2023

DOI: 10.1080/21678421.2023.2239857

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Validity and reliability measures of the Swedish Karolinska version of the Edinburgh Cognitive and Behavioral ALS Screen (SK-ECAS)

Juliette Foucher

Ivar Winroth

Anikó Lovik

et al.

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2024

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Cited by 2 publications

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Repeated cognitive assessments show stable function over time in patients with ALS

Öijerstedt,

Foucher,

Lovik

et al. 2024

J Neurol

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Background Amyotrophic lateral sclerosis (ALS) is a multisystem disorder with not only motor symptoms but also extra-motor features including cognitive impairment. The most common cognitive profile observed in patients with ALS includes deficits in executive function, language, and social cognition. However, longitudinal studies on cognitive changes over time in ALS are sparse. We aimed to investigate the presence and nature of cognitive impairment at the time of ALS diagnosis and its association with survival as well as explore longitudinal cognitive change. Method Patients (n = 216) were recruited at the Karolinska University Hospital in Stockholm, Sweden. Follow-up visits (n = 307 in total) were performed every 6 months. Cognitive impairment was assessed using the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) and/or Montreal Cognitive Assessment (MoCA). Results Cognitive impairment was observed in 38% of the patients at the time of ALS diagnosis, and the majority of these patients had deficits in executive function and/or language. Patients with cognitive impairment at the time of diagnosis had a more rapid decline in ALSFRS-R at 12- and 18-months follow-up, and a shorter survival. Cognitive function was stable during the first 2 years after diagnosis, and did not follow the trajectories of decline in motor functions. Conclusion Cognitive impairment in ALS was associated with a faster decline of motor functions, and shorter survival. However, cognitive function did not deteriorate over time. Cognitive assessment is essential for the patients and caregivers to understand the phenotypic expression of ALS.

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Repeated cognitive assessments show stable function over time in patients with ALS

Öijerstedt,

Foucher,

Lovik

et al. 2024

J Neurol

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ECAS correlation with metabolic alterations on FDG-PET imaging in ALS

Foucher,

Öijerstedt,

Lovik

et al. 2024

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

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Validity and reliability measures of the Swedish Karolinska version of the Edinburgh Cognitive and Behavioral ALS Screen (SK-ECAS)

Cited by 2 publications

References 20 publications

Repeated cognitive assessments show stable function over time in patients with ALS

Repeated cognitive assessments show stable function over time in patients with ALS

ECAS correlation with metabolic alterations on FDG-PET imaging in ALS

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