Validierung der kontinuierlichen nicht-invasiven Blutdruckmessung mittels Puls-Transit-Zeit

Bartsch, Stephan; Ostojic, Dominique; Schmalgemeier, Heidi; Bitter, Thomas; Westerheide, Nina; Eckert, Siegfried; Horstkotte, Dieter; Oldenburg, Olaf

doi:10.1055/s-0030-1269408

Cited by 27 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During study nights, oxygen saturation (SpO 2 ), electrocardiogram and derived parameters as described in previous studies (blood pressure, Puls Transit Time, heart rate acceleration) [6, 14, 39] were continuously measured by wearing portable polygraphic screening devices (SOMNO Watch™plus or SOMNO touch™, SOMNOmedics GmbH, Randersacker, Germany).…”

Section: Methodsmentioning

confidence: 99%

Acute exposure to nocturnal train noise induces endothelial dysfunction and pro-thromboinflammatory changes of the plasma proteome in healthy subjects

et al. 2019

View full text Add to dashboard Cite

Nocturnal train noise exposure has been associated with hypertension and myocardial infarction. It remains unclear whether acute nighttime train exposure may induce subclinical atherosclerosis, such as endothelial dysfunction and other functional and/or biochemical changes. Thus, we aimed to expose healthy subjects to nocturnal train noise and to assess endothelial function, changes in plasma protein levels and clinical parameters. In a randomized crossover study, we exposed 70 healthy volunteers to either background or two different simulated train noise scenarios in their homes during three nights. After each night, participants visited the study center for measurement of vascular function and assessment of other biomedical and biochemical parameters. The three nighttime noise scenarios were exposure to either background noise (control), 30 or 60 train noise events (Noise30 or Noise60), with average sound pressure levels of 33, 52 and 54 dB(A), respectively. Flow-mediated dilation (FMD) of the brachial artery was 11.23 ± 4.68% for control, compared to 8.71 ± 3.83% for Noise30 and 8.47 ± 3.73% for Noise60 (p < 0.001 vs. control). Sleep quality was impaired after both Noise30 and Noise60 nights (p < 0.001 vs. control). Targeted proteomic analysis showed substantial changes of plasma proteins after the Noise60 night, mainly centered on redox, pro-thrombotic and proinflammatory pathways. Exposure to simulated nocturnal train noise impaired endothelial function. The proteomic changes point toward a proinflammatory and pro-thrombotic phenotype in response to nocturnal train noise and provide a molecular basis to explain the increased cardiovascular risk observed in epidemiological noise studies.Electronic supplementary materialThe online version of this article (10.1007/s00395-019-0753-y) contains supplementary material, which is available to authorized users.

show abstract

Section: Methodsmentioning

confidence: 99%

Acute exposure to nocturnal train noise induces endothelial dysfunction and pro-thromboinflammatory changes of the plasma proteome in healthy subjects

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Continuous beat-to-beat measurements of BP obtained by the computation of the PTT from electrocardiography (ECG) and peripheral PPG signals however, are disputable for several reasons: (i) the dependency on the location and the distance of measurement points, (ii) the method used to find and interpret minima, maxima and saddle points within the PPG and ECG signals [5,6], (iii) the appearance of undetermined fluctuations in the time between the pressure wave and the ECG R-peak during blood ejection of the left ventricle [7] and (iv) the influences of auto-regulation on arterial stiffness that produce undetermined drifts of the PTT over time [8]. Nonetheless, the PTT method is subject of several publications that aim at a development of wearable continuous BPM devices [5,[9][10][11][12][13]. As PTT-based methods compute the BP by employing its correlation with the actual pulse wave velocity (PWV), the particular drawback of this approach is that PWV depends on the elasticity of the tested artery section, which in turn is considerably affected by a variety of physiological mechanisms of BP regulation.…”

Section: Introductionmentioning

confidence: 99%

Estimation of Quasi-Continuous Blood Pressure based on Harmonic Phase-Shifts in Signals using Non-Invasive Photoplethysmographic Measurements

Kern

Bernhard

2019

Preprint

View full text Add to dashboard Cite

According to the guidelines of the European Society of Hypertension International Protocol revision 2010, the requirements for long time blood pressure measurement (BPM) are: simple handling, robustness against movements, accuracy of better than 5 mmHg, and, above all, that the patient's motion should not be restricted during measurement. These requirements are in particular important for a reliable interpretation of the blood pressure (BP) of hypertensive patients, because such a diagnosis will usually be confirmed by long-term measurement. Moreover, to be able to correlate the patient's BP with his normal daily activity, non-obstructive non-invasive methods are desired to reduce the patient's load. The main concern of this paper is to present a novel method for estimating non-invasive continuous blood pressure (CBP) from a single photoplethysmography (PPG) signal. In contrast to the pulse transit time (PTT) method, our approach is based on the assumption that the phase-velocities of the fundamental and higher harmonics depend on the (non-linear) elastic properties of the arteries. Consequently, phase velocity varies as a function of a vessel's instantaneous dilation and can be effectively utilised for CBP estimation. In addition to its numerous advantages for a simplified measurement setup, we could show that the method achieves a high degree of correlation for a reliable BP estimation from PPG data. Comparison with state-of-the-art PTT methods was carried out using a dataset from the PhysioBank Database comprising a reference invasive blood pressure (IBP) signal measured at the radial artery, a PPG signal measured at the fingertip and a standard ECG signal. The correlation values obtained from the long-time estimation of the systolic blood pressure (SBP) were as high as r = 0.8945, while the value for the diastolic blood pressure (DBP) was found to be r = 0.9082 and the correlation of the mean blood pressure (MBP) was r = 0.9322. These results were achieved by analysing the dataset in a beat-to-beat manner and regarding several post-processing procedures like coherent averaging (CA) and zero padding with quasi-continuous frequency domain estimation and artificially refined frequency resolution.

show abstract

Continuous blood pressure measurement by using the pulse transit time: comparison to a cuff-based method

Gesche

D²,

Küchler³

et al. 2011

Eur J Appl Physiol

403

263

View full text Add to dashboard Cite

Pulse transit time (PTT) and pulse wave velocity (PWV), respectively, were shown to have a correlation with systolic blood pressure (SBP) and have been reported to be suitable for indirect BP measurements. The aim of this study was to create a function between SBP and PWV, and to test its reliability for the determination of absolute SBP using a non-linear algorithm and a one-point calibration. 63 volunteers performed exercise to induce rises in BP. Arterial PTT was measured between the R-spike of the ECG and the plethysmographic curve of finger pulse-oximetry. The reference BP was measured using a cuff-based sphygmomanometric aneroid device. Data from 13 of the 63 volunteers served for the detection of the PWV-BP relationship. The created non-linear function was used to calculate BP values after individual correction for the BP offset in a group of 50 volunteers. Individual correlation coefficients for SBP measured by PTT (SBP(PTT)) and by cuff (SBP(CUFF)) varied between r = 0.69 and r = 0.99. Taking all data together, we found r = 0.83 (276 measurements in 50 volunteers). In the Bland-Altman plot, the limits of agreement were [Formula: see text]± 19.8 mmHg. In conclusion, comparing SBP values using the PTT-based method and those measured by cuff resulted in a significant correlation. However, the Bland-Altman plot shows relevant differences between both methods, which are partly due to greater variability of the SBP(PTT) measurement during intensified exercise. Results suggest that PTT can be used for measuring absolute SBP when performing an individual correction for the offset of the BP-PWV relation.

show abstract

Validierung der kontinuierlichen nicht-invasiven Blutdruckmessung mittels Puls-Transit-Zeit

Cited by 27 publications

References 20 publications

Acute exposure to nocturnal train noise induces endothelial dysfunction and pro-thromboinflammatory changes of the plasma proteome in healthy subjects

Acute exposure to nocturnal train noise induces endothelial dysfunction and pro-thromboinflammatory changes of the plasma proteome in healthy subjects

Estimation of Quasi-Continuous Blood Pressure based on Harmonic Phase-Shifts in Signals using Non-Invasive Photoplethysmographic Measurements

Continuous blood pressure measurement by using the pulse transit time: comparison to a cuff-based method

Contact Info

Product

Resources

About