Validation of transthoracic myocardial ultrasonic tissue characterization: comparison of transthoracic and open-chest measurements of integrated backscatter

Naito, Junko; Masuyama, Tohru; Mano, Toshiaki; Yamamoto, Keiji; Doi, Yasuji; Kondo, Hiroya; Hori, Masatsugu; Shiba, Akira; Murakami, Keiichi; Shimura, T.; Kamada, Takenobu

doi:10.1016/0301-5629(94)00100-6

Cited by 31 publications

(10 citation statements)

References 19 publications

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“…The interobserver and intraobserver variabilities have been compared in 60 consecutive measurements and were 4.7% and 3.2%, respectively. Validation had been performed previously in physical models, 19 animal models 17,20 and human subjects, 21 and TDI was found to be accurate to assess regional velocity and timing of cardiac events. 12…”

Section: Circulation January 29 2002mentioning

confidence: 83%

Tissue Doppler Echocardiographic Evidence of Reverse Remodeling and Improved Synchronicity by Simultaneously Delaying Regional Contraction After Biventricular Pacing Therapy in Heart Failure

et al. 2002

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Background-Biventricular pacing has been proposed to improve symptoms and exercise capacity in patients with advanced heart failure and wide electrocardiographic wave complexes. This study investigated the effect of biventricular pacing on reverse remodeling and the underlying mechanisms. Methods and Results-Twenty-five patients with NYHA class III to IV heart failure and electrocardiographic wave complex duration Ͼ140 ms receiving biventricular pacing therapy were assessed serially up to 3 months after pacing and when pacing was withheld for 4 weeks. Tissue Doppler echocardiography was performed using a 6-basal, 6-mid segmental model to assess the time to peak sustained systolic contraction (T S ). There was significant improvement of ejection fraction, dP/dt, and myocardial performance index; decrease in mitral regurgitation, left ventricular (LV) end-diastolic (205Ϯ68 versus 168Ϯ67 mL, PϽ0.01) and end-systolic volume (162Ϯ54 versus 122Ϯ42 mL, PϽ0.01); and improved 6-minute hall-walk distance and quality of life score after pacing for 3 months. The mechanisms of benefits were as follows: (1)

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Section: Circulation January 29 2002mentioning

confidence: 83%

Tissue Doppler Echocardiographic Evidence of Reverse Remodeling and Improved Synchronicity by Simultaneously Delaying Regional Contraction After Biventricular Pacing Therapy in Heart Failure

et al. 2002

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“…As a consequence, if CV is predominately determined by changes in scatterer concentration, then CV values are also not influenced by parallel beam-forming. As absolute IB measurements in clinical practice are made relative to a reference reflector [35] which will change accordingly, and since CV is not influenced by parallel beam-forming, we can conclude that IB traces acquired with parallel processing can be directly compared with those obtained using conventional technology (i.e. acquired without parallel beam-forming).…”

Section: Discussionmentioning

confidence: 89%

High Frame Rate Myocardial Integrated Backscatter. Does this Change our Understanding of this Acoustic Parameter?

D'hooge

Bijnens

Jamal

et al. 2000

European Journal of Echocardiography

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Aims: Integrated backscatter (IB) and its cyclic variation (CV) derived from radio-frequency (RF) data have been used as parameters to attempt myocardial tissue characterization. Prior imaging systems used to measure IB and its CV typically acquired data at frame rates of 20-30 Hz and at a resolution of 6-8 bits. If changes in IB levels are in part related to specific short-lived events, occurring within the cardiac cycle, this frame rate and resolution could have been too low to resolve adequately what might be a more complex data set. Methods and Results:To investigate this possibility, we acquired real time two-dimensional (2D) myocardial IQ data (the 'in-phase quadrature' sampled RF data) at high frame rate (>100 Hz), high dynamic resolution (theoretical 19-bit) and a sector angle of 20 . Several consecutive heart cycles of myocardial data were acquired from individual cardiac walls in five closed chest dogs and 10 healthy, young volunteers at normal heart rates. On the reconstructed RF data regions of interest were indicated, and IB and its CV were calculated.The extracted high frame rate curves showed that the CV of IB is not a smooth sinusoidal-like curve, but is made up of multiple reproducible peaks and troughs with local minima and maxima which are temporally related to active or passive mechanical events, i.e. systolic contraction, early ventricular relaxation and ventricular filling due to atrial contraction. Conclusions:This study shows that increasing the rate of real-time RF data acquisition results in a more complex, reproducible IB curve. The resolved maxima and minima in IB levels are related to specific phases of the myocardial contraction. Furthermore, spectral analysis showed that IB curves acquired at normal heart rates contain information up to 40 Hz. Hence, cardiac imaging data sets used to analyse regional myocardial function obtained at frequencies lower than 80 frames per second can contain aliased information.

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“…The concept of using moving (arterial) blood as a backscatter reference in order to determine the absolute value of integrated backscatter of an unknown tissue interface was proposed in 1988 by Nakayama 15 and has successfully been used for in vivo myocardial tissue characterization 16,17 . In 18 , the absolute backscatter power was measured for the purpose of estimating the size of microemboli.…”

Section: Concept Behind the Measurement Of Absolute Ibsmentioning

confidence: 99%

Ultrasound characterization of arterial wall structures based on integrated backscatter profiles

2003

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Studies suggest that the composition of atherosclerotic plaque in the carotid arteries is predictive of stroke risk. The goal of this investigation has been to explore how well the true integrated backscatter (IBS) from plaque regions can be measured non-invasively using ultrasound, based on which plaque composition may be inferred. To obtain the true arterial IBS non-invasively, the scattering and aberating effect of the intervening tissue layers must be overcome. This is achieved by using the IBS from arterial blood as a reference backscatter, specifically the backscatter from a blood volume along the same scan line as and adjacent to the region of interest. The arterial blood IBS is obtained as an estimated mean of a stochastic process, after clutter removal. We have shown that the variance of the IBS estimate of the blood backscatter signal can be quantified and reduced to a tolerable level. The results are in the form of IBS profiles along the vessel. IBS profiles not normalized with the IBS of the blood-mimicking fluid have been measured for vessels phantom, with and without an intervening inhomogeneous medium; these results are contrasted with the corresponding normalized IBS profiles.

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Validation of transthoracic myocardial ultrasonic tissue characterization: comparison of transthoracic and open-chest measurements of integrated backscatter

Cited by 31 publications

References 19 publications

Tissue Doppler Echocardiographic Evidence of Reverse Remodeling and Improved Synchronicity by Simultaneously Delaying Regional Contraction After Biventricular Pacing Therapy in Heart Failure

Tissue Doppler Echocardiographic Evidence of Reverse Remodeling and Improved Synchronicity by Simultaneously Delaying Regional Contraction After Biventricular Pacing Therapy in Heart Failure

High Frame Rate Myocardial Integrated Backscatter. Does this Change our Understanding of this Acoustic Parameter?

Ultrasound characterization of arterial wall structures based on integrated backscatter profiles

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