Validation of the Ukrainian version of the PedsQLTM 4.0 Generic Core Scales in children and adolescents with vasovagal syncope

Abstract

Introduction: The aim of the study was to assess the psychometric properties of the Ukrainian translation of the PedsQL™ 4.0 Generic Core Scales for Ukrainian children and adolescents with vasovagal syncope, as well as to study health-related quality of life in this group of paediatric patients. Materials and methods: We studied 56 children, aged eight to 17 years, with a history of vasovagal syncope, and 41 healthy volunteers. Health-related quality of life assessment was performed using the Ukrainian version of the PedsQL™ 4.0 Generic Core Scales for child self-reporting and parent proxy-reporting. Results: There were no significant floor or ceiling effects for any of the summary or scale scores for patient self-reporting and parent proxy-reporting. Cronbach's α coefficient for PedsQL total score for patient self-reporting was 0.90, and for parent proxy-reporting it was 0.88. Paediatric patients with vasovagal syncope (67.92 ±14.52; 77.36 ±21.73; p = 0.01) and their parents (65.13 ±13.94; 71.77 ±13.76; p = 0.02) reported worse PedsQL total scores than healthy children. According to the results of exploratory factor analysis, almost all items of child self-reporting and parent proxy-reporting had a clear factor loading. Regarding construct validity, the results revealed a positive linear relationship between the PedsQL™ 4.0 Generic Core Scales and Modified Calgary Syncope Seizure Score, PedsQL™ General Well-Being Scale, and PedsQL™ Multidimensional Fatigue Scale. Calculation of Pearson's correlation index revealed moderate (0.41-0.60) to good (0.61-0.80) child-parent agreement. Conclusions: The results demonstrate the feasibility, reliability, validity, and agreement between child selfreporting and parent proxy-reporting of the Ukrainian version of the PedsQL™ 4.0 Generic Core Scales for health-related quality of life assessment in children and adolescents with vasovagal syncope. These patients have lower psychosocial health, emotional functioning, and social functioning in comparison to healthy children and adolescents.

Evaluating the Impact of Orthostatic Syncope and Presyncope on Quality of Life: A Systematic Review and Meta-Analysis

“…Individual study results, including baseline quality of life scores, between-group comparisons and additional contextual findings are reported in Table 2. To avoid redundancy in our reporting, data from three longitudinal studies (26,35,36) have been omitted from Table 2; their results, including baseline scores, comparisons and contextual findings can be found in Table 3. We note that these three studies report follow-up data from three prior studies that are described in Table 2 (26,41,42).…”

“…VAS (EQ VAS or global health) scores were significantly reduced in VVS, POTS, and OH patient populations ( 10 , 49 , 54 ), and EQ-5D-3L index scores were additionally found to be reduced in patients with OH ( 54 ). Two studies showed that total PedsQL scores (child self-reported) were significantly reduced in children with VVS compared to healthy controls ( 8 , 35 ).…”

“…Studies using the EQ-5D-3L showed that, in all five dimensions (mobility, usual activities, self-care, pain/discomfort and anxiety/depression) of the instrument, the prevalence of individuals reporting some or extreme problems was increased in patients with VVS, POTS, and OH compared to control or reference data ( 32 , 49 , 54 ). Two studies evaluated quality of life in pediatric patients with VVS using the PedsQL and reported impairments in psychosocial health and emotional functioning domains ( 8 , 35 ); one detected additional impairments in school and physical functioning domains ( 8 ), and the other reported impaired social functioning ( 35 ).…”

Quality of life indicators in children with non-traumatic and non-syncopal transient loss of consciousness and their families

“…Хронічні захворювання дитячого віку, включно з ТВС, обумовлюють суттєві зміни у всіх сферах життя дитини -у повсякденних справах, емоційному та когнітивному розвитку, формуванні самооцінки та соціальних контактів із іншими людьми [3, [10][11][12]. Це дослідження було змодельоване таким чином, щоб вивчити вплив епілепсії, ПНЕН та психогенних ТВС на особливості якості життя дітей та функціонування їхніх сімей.…”

“…До того ж визначення якості життя дітей і надалі залишається важливим інструментом оцінки якості надання медичних послуг [7]. Станом на сьогодні є чимало досліджень, які доводять негативний вплив транзиторних втрат свідомості (ТВС) синкопального походження на показники якості життя дітей, пов'язаної зі здоров'ям [8][9][10]. Доведено, що погіршення якості життя у педіатричних пацієнтів із епілепсією як проявом ТВС несинкопального походження асоціюється з тривалістю захворювання та частотою судом, необхідністю використання кількох протисудомних препаратів [11].…”