Validation of the St. George's Respiratory Questionnaire in Bronchiectasis

Wilson, C B; Jones, Paul; O’Leary, Catherine; Cole, Peter; Wilson, Robert

doi:10.1164/ajrccm.156.2.9607083

Cited by 337 publications

(301 citation statements)

References 19 publications

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“…Although the measurement of quality of life could be eligible for this, its application is not generalised and the measuring instruments are not usually validated for individual use [21,22]. Therefore, as with other airway diseases such as COPD [14,15] and infectious diseases such as pneumonia [23], it is necessary to construct and validate a score that pinpoints more effectively than any single variable the severity or prognosis of bronchiectasis by embracing the various clinical, functional, radiological and microbiological aspects characteristic of the disease.…”

Section: Discussionmentioning

confidence: 99%

Multidimensional approach to non-cystic fibrosis bronchiectasis: the FACED score

Martínez‐García

Gracia

Relat

et al. 2013

European Respiratory Journal

372

255

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Bronchiectasis is a multidimensional disease and, therefore, its severity or prognosis cannot be adequately quantified by analysing one single variable. The objective of the present study was to develop a multidimensional score that classifies the severity of bronchiectasis according to its prognosis. This is an observational multicentre study including 819 patients diagnosed with non-cystic fibrosis bronchiectasis using high-resolution computed tomography. 397 subjects were selected at random to construct the score while the remaining 422 were used for its validation. The outcome was 5-year all-cause mortality after radiological diagnosis. A logistic regression analysis was used to select the variables included in the final score.The final seven-point score incorporated five dichotomised variables: forced expiratory volume in 1 s % predicted (F, cut-off 50%, maximum value 2 points); age (A, cut-off 70 years, maximum value 2 points); presence of chronic colonisation by Pseudomonas aeruginosa (C, dichotomic, maximum value 1 point); radiological extension (E, number of lobes affected, cut-off two lobes, maximum value 1 point); and dyspnoea (D, cut-off grade II on the Medical Research Council scale, maximum value 1 point) to construct the FACED score. The validation cohort confirmed the score's validity.We conclude that this easy-to-use multidimensional grading system proved capable of accurately classifying the severity of bronchiectasis according to its prognosis. @ERSpublications An easy-to-use multidimensional grading system accurately classifies bronchiectasis severity according to prognosis

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Section: Discussionmentioning

confidence: 99%

Multidimensional approach to non-cystic fibrosis bronchiectasis: the FACED score

Martínez‐García

Gracia

Relat

et al. 2013

European Respiratory Journal

372

255

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“…Patients completed the St. George's Respiratory Questionnaire (18) as a measure of quality of life. The widely used minimal important clinical difference is a change of 4 units (18).…”

Section: End-pointsmentioning

confidence: 99%

The Bronchiectasis Severity Index. An International Derivation and Validation Study

Chalmers

Goeminne²,

Aliberti

et al. 2014

Am J Respir Crit Care Med

776

836

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Rationale: There are no risk stratification tools for morbidity and mortality in bronchiectasis. Identifying patients at risk of exacerbations, hospital admissions, and mortality is vital for future research.Objectives: This study describes the derivation and validation of the Bronchiectasis Severity Index (BSI).Methods: Derivation of the BSI used data from a prospective cohort study (Edinburgh, UK, 2008 enrolling 608 patients. Cox proportional hazard regression was used to identify independent predictors of mortality and hospitalization over 4-year follow-up. The score was validated in independent cohorts from Dundee, UK (n = 218); Leuven, Belgium (n = 253); Monza, Italy (n = 105); and Newcastle, UK (n = 126).Measurements and Main Results: Independent predictors of future hospitalization were prior hospital admissions, Medical Research Council dyspnea score greater than or equal to 4, FEV 1 , 30% predicted, Pseudomonas aeruginosa colonization, colonization with other pathogenic organisms, and three or more lobes involved on high-resolution computed tomography. Independent predictors of mortality were older age, low FEV 1 , lower body mass index, prior hospitalization, and three or more exacerbations in the year before the study. The derived BSI predicted mortality and hospitalization: area under the receiver operator characteristic curve (AUC) 0.80 (95% confidence interval, 0.74-0.86) for mortality and AUC 0.88 (95% confidence interval, 0.84-0.91) for hospitalization, respectively.There was a clear difference in exacerbation frequency and quality of life using the St. George's Respiratory Questionnaire between patients classified as low, intermediate, and high risk by the score (P , 0.0001 for all comparisons). In the validation cohorts, the AUC for mortality ranged from 0.81 to 0.84 and for hospitalization from 0.80 to 0.88. Conclusions:The BSI is a useful clinical predictive tool that identifies patients at risk of future mortality, hospitalization, and exacerbations across healthcare systems.

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“…14 The SGRQ is a questionnaire designed to measure the influence of chest diseases on HRQL. 14,23,24 The 50 items can be aggregated into an overall score and 3 subscores, for symptoms (8 items), activity (16 items), and impact (26 items). Responses are weighted and scores are calculated by dividing the summed weights by the maximum possible weight, 0 being the best possible score, and 100 the worst.…”

Section: Cardiopulmonary Exercise Testmentioning

confidence: 99%

“…Responses are weighted and scores are calculated by dividing the summed weights by the maximum possible weight, 0 being the best possible score, and 100 the worst. 14,23,24 The SGRQ has been reported to be valid and reliable in subjects with COPD, asthma, and bronchiectasis. 14,23,24 …”

Section: Cardiopulmonary Exercise Testmentioning

confidence: 99%

Benefits of Pulmonary Rehabilitation in Patients With COPD and Normal Exercise Capacity

et al. 2013

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BACKGROUND: Pulmonary rehabilitation (PR) is beneficial for patients with COPD, with improvement in exercise capacity and health-related quality of life. Despite these overall benefits, the responses to PR vary significantly among different individuals. It is not clear if PR is beneficial for patients with COPD and normal exercise capacity. We aimed to investigate the effects of PR in patients with normal exercise capacity on health-related quality of life and exercise capacity. METHODS: Twenty-six subjects with COPD and normal exercise capacity were studied. All subjects participated in 12-week, 2 sessions per week, hospital-based, out-patient PR. Baseline and post-PR status were evaluated by spirometry, the St George's Respiratory Questionnaire, cardiopulmonary exercise test, respiratory muscle strength, and dyspnea scores. RESULTS: The mean FEV 1 in the subjects was 1.29 ؎ 0.47 L/min, 64.8 ؎ 23.0% of predicted. After PR there was significant improvement in maximal oxygen uptake and work rate. Improvements in St George's Respiratory Questionnaire scores of total, symptoms, activity, and impact were accompanied by improvements of exercise capacity, respiratory muscle strength, maximum oxygen pulse, and exertional dyspnea scores (all P < .05). There were no significant changes in pulmonary function test results (FEV 1 , FVC, and FEV 1 /FVC), minute ventilation, breathing frequency, or tidal volume at rest or exercise after PR. CONCLUSIONS: Exercise training can result in significant improvement in health-related quality of life, exercise capacity, respiratory muscle strength, and exertional dyspnea in subjects with COPD and normal exercise capacity. Exercise training is still indicated for patients with normal exercise capacity.

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Validation of the St. George's Respiratory Questionnaire in Bronchiectasis

Cited by 337 publications

References 19 publications

Multidimensional approach to non-cystic fibrosis bronchiectasis: the FACED score

Multidimensional approach to non-cystic fibrosis bronchiectasis: the FACED score

The Bronchiectasis Severity Index. An International Derivation and Validation Study

Benefits of Pulmonary Rehabilitation in Patients With COPD and Normal Exercise Capacity

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