Validation of the Same-TT2R2 Score in a Multiethnic Cohort of Asian Patients with Atrial Fibrillation on Warfarin Therapy – A Multicenter Study

Khaw, Chee Sin; Lim, Melissa; Tiong, Lee Len; Tan, S.S.N.; Ku, Ming-Chou; Tan, Clare; Lau, E.; Azila, A.L. Nor; Lum, Kirsten; Lee, Q.J.; Nagappa, K.; Cham, Y.L.; Ong, T.K.; Lip, Gregory Y.H.; Fong, A.Y.Y.

doi:10.1016/j.ijcard.2017.09.115

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This led to the suggestion that the scoring system may not be predictive of good AC in Asian populations including Koreans. Although studies of various sample sizes of Asian patients with AF have been conducted, the results relating to the SAMe-TT 2 R 2 score have been inconsistent [ 9 , 10 , 22 , 23 ]. When compared to Western populations, Asian populations generally have a lower body mass index and different pharmacodynamics to various drugs [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hence, heterogeneous results in studies that validated the SAMe-TT 2 R 2 score in Asians may be caused by racial differences. A multi-center multi-ethnic cohort study that included Malay, Chinese, and non-Malay patients showed that the SAMe-TT 2 R 2 score failed to predict a TTR ≥ 65% [ 23 ]. Subgroup analyses revealed that the median TTR significantly differed for each ethnic group and hospital setting.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Modified application of SAMe-TT2R2 scoring system in Asian patients with atrial fibrillation for the selection of oral anticoagulants

Jeon,

Lee,

Lee

et al. 2024

Korean J Intern Med

View full text Add to dashboard Cite

Background/Aims: The SAMe-TT2R2 score is used for assessing anticoagulation control (AC) quality with warfarin. However, it is hard to apply SAMe-TT2R2 score in Asian patients with atrial fibrillation (AF), because it has not been proven in those populations. This study aimed to validate the SAMe-TT2R2 score in Asian patients with AF and suggest a modified SAMe- TT2R2 score for this population.Methods: We analyzed 710 Korean patients with AF who were using warfarin. The AC quality was assessed as the mean time in therapeutic range (TTR). Each component of SAMe-TT2R2 score was evaluated for the relationship with AC. Further clinical factors that predict AC were analyzed. Identified factors were re-assorted and constructed as SA2Me-TTR scoring system.Results: Of the components of the SAMe-TT2R2 score, female, age, and rhythm control were associated with AC. Heart failure and renal insufficiency were newly identified factors associated with AC. The modified SA2Me-TTR score was reconstructed with the relevant risk factors (S, female gender, 1 point; A, age < 60 yr, 2 points; Me, medical history of heart failure, 1 point; T, treatment for rhythm control, 1 point; T, history of stroke or transient ischemic attack, 1 point; R, renal insufficiency, 1 point). The modified SA2Me-TTR score demonstrated an excellent relationship with the grading of AC. The modified SA2Me-TTR score ≤ 1 identified patients with good AC (hazard ratio 2.46, 95% CI 1.75–3.47).Conclusions: The modified SA2Me-TTR score was useful for guiding oral anticoagulants selection in Asian patients with AF.

show abstract