Validation of the revised Addenbrooke's Cognitive Examination (ACE-R) for detecting mild cognitive impairment and dementia in a Japanese population

Yoshida, Hidenori; Terada, Seishi; Honda, Hiroki; Kishimoto, Yuki; Takeda, Naoya; Oshima, Etsuko; Hirayama, Keisuke; Yokota, Osamu; Uchitomi, Yosuke

doi:10.1017/s1041610211001190

Cited by 51 publications

(64 citation statements)

References 23 publications

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“…Some of the results are similar to those from two recent studies [7,31]. One study with 242 subjects including 39 MCI subjects and 73 controls conducted by Yoshida et al [31] in Japan indicated that the cutoff of ACE-R was 88/89 to screen for MCI (our cutoff is 85/86).…”

Section: Discussionsupporting

confidence: 88%

Validation of the Chinese Version of Addenbrooke's Cognitive Examination-Revised for Screening Mild Alzheimer's Disease and Mild Cognitive Impairment

Fang

Wang

Huang

et al. 2013

Dement Geriatr Cogn Disord

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Background/Aims: As a suitable test to screen for Alzheimer's disease (AD) or mild cognitive impairment (MCI), studies to validate the Chinese version of Addenbrooke's Cognitive Examination-Revised (ACE-R) are rare. Methods: A total of 151 subjects were recruited and the neuropsychological assessments were employed. One-way analysis of variance and Bonferroni correction were used to compare scores of different psychometric scales. Intraclass correlation coefficient (ICC) and Cronbach's coefficient α were used to evaluate the reliability of psychometric scales. The validity of ACE-R to screen for mild AD and amnestic subtype of MCI (a-MCI) was assessed by receiver operating characteristic (ROC) curves. Results: The Chinese ACE-R had good reliability (inter-rater ICC = 0.994; test-retest ICC = 0.967) as well as reliable internal consistency (Cronbach's coefficient α = 0.859). With its cutoff of 67/68, the sensitivity (0.920) and specificity (0.857) were lower than for the Mini-Mental State Examination (MMSE) cutoff (sensitivity 1.000 and specificity 0.937) to screen for mild AD. However, the sensitivity of ACE-R to screen for a-MCI was superior to the MMSE with a cutoff of 85/86. The specificity of ACE-R was lower than that of the MMSE to screen for a-MCI. The area under the ROC curve of ACE-R was much larger than that of the MMSE (0.836 and 0.751) for detecting a-MCI rather than mild AD. Conclusion: The Chinese ACE-R is a reliable assessment tool for cognitive impairment. It is more sensitive and accurate in screening for a-MCI rather than for AD compared to the MMSE.

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Section: Discussionsupporting

confidence: 88%

Validation of the Chinese Version of Addenbrooke's Cognitive Examination-Revised for Screening Mild Alzheimer's Disease and Mild Cognitive Impairment

Fang

Wang

Huang

et al. 2013

Dement Geriatr Cogn Disord

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“…There are a number of reasons to analyse this brief cognitive test in relation to on-road driving performance. Firstly, it is a more accurate means of detecting early cognitive dysfunction than the MMSE, with a number of added items to increase its sensitivity to specific dementing diseases (e.g., Alexopoulos et al, 2010;Mioshi et al, 2006;Simões et al, 2011;Torralva et al, 2011;Yoshida et al, 2012) that might adversely affect driving abilities and increase crash risk (Iverson et al, 2010). Secondly, it comprises an MMSE score and sub-scores in five cognitive domains, which could provide qualitative and discriminative data regarding the patient's driving-related cognitive profile.…”

Section: Introductionmentioning

confidence: 99%

The Addenbrooke's Cognitive Examination Revised as a potential screening test for elderly drivers

Ferreira

Simões

Marôco

2012

Accident Analysis & Prevention

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a b s t r a c tConsiderable research has shown that neuropsychological tests are predictive of real-world driving ability. The Mini-Mental State Examination (MMSE) is a brief cognitive test that has been commonly used in the assessment of older drivers. However, this test has inherent problems that limit its validity to evaluate cognitive abilities related to driving and to screen for driving impairments in non-demented people. Therefore, it is useful to test new screening instruments that may predict potential unsafe drivers who require an in-depth neuropsychological assessment in a specialised centre. To date, the utility of the Addenbrooke's Cognitive Examination Revised (ACE-R) as an indicator of driving ability has not been established. In the current study, fifty older drivers (mean age = 73.1 years) who were referred for a psychological assessment, the protocol of which included the ACE-R, underwent an on-road driving test. Using linear discriminant analyses, the results highlighted the higher classification accuracy of the ACE-R compared to the MMSE score, particularly for detecting unsafe drivers. Measures of visuospatial and executive functions, which are not incorporated in the MMSE score, had an incremental value in the prediction of driving ability. This emerging brief cognitive test may warrant additional study for use in the fitness to drive assessment of older adults.

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“…Данные крите-рии предполагают наличие деменции по результатам клинического и нейропсихологического обследова-ния. Тот же подход использован и в обновленных кри-териях диагностики деменции при БА [16], однако в данном исследовании мы использовали критерии NINCDS-ADRDA, как и в оригинальном исследова-нии по валидизации АКШ и АКШ-м [10,11].…”

Section: Discussionunclassified

“…В исследованиях по валидизации АКШ-м на других языках пороговое значение для диагно-стики деменции по данным АКШ-м варьировало от 79 до 85 баллов [3][4][5][6][7][8][9]. Самый высокий балл (88) был получен в оригинальных исследованиях АКШ и АКШ-м [10,11]. В настоящем исследовании опти-мальное пороговое значение для диагностики де-менции составило 78 баллов с очень высокими зна-чениями чувствительности и специфичности (96 и 97% соответственно).…”

Section: Discussionunclassified

“…АКШ была валидизирована на нескольких язы-ках, включая индийский [4], французский [5], ис-панский [6], немецкий [7], датский [8], итальянский [9] и японский [10]. АКШ имеет более высокие чув-ствительность и специфичность, чем MMSE, при диагностике ранних стадий деменции.…”

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Validation of the Russian version of the modified Addenbrooke’s cognitive examination for Alzheimer’s disease diagnosis

Левин¹,

Lavrov²,

Lyashenko³

et al. 2015

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Validation of the revised Addenbrooke's Cognitive Examination (ACE-R) for detecting mild cognitive impairment and dementia in a Japanese population

Abstract: ACE-R J proved to be an accurate cognitive instrument for detecting MCI and mild dementia. Further neuropsychological evaluation is required for the differential diagnosis of dementia subtypes.

Cited by 51 publications

References 23 publications

Validation of the Chinese Version of Addenbrooke's Cognitive Examination-Revised for Screening Mild Alzheimer's Disease and Mild Cognitive Impairment

Validation of the Chinese Version of Addenbrooke's Cognitive Examination-Revised for Screening Mild Alzheimer's Disease and Mild Cognitive Impairment

The Addenbrooke's Cognitive Examination Revised as a potential screening test for elderly drivers

Validation of the Russian version of the modified Addenbrooke’s cognitive examination for Alzheimer’s disease diagnosis

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