Validation of the Regicor Short Physical Activity Questionnaire for the Adult Population

Molina, Luís; Sarmiento, Manuel; Peñafiel, Judith; Donaire, David; Garcia‐Aymerich, Judith; Gomez, Miquel; Blé, Mireia; Ruiz, Sonia; Francés, Albert; Schröder, Helmut; Marrugat, Jaume; Elosúa, Roberto

doi:10.1371/journal.pone.0168148

Cited by 146 publications

(112 citation statements)

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“…PA was assessed using the validated REGICOR questionnaire and the Rapid Assessment of Physical Activity Questionnaire (RAPA) 47 . REGICOR questionnaire provides information about PA intensity according to energy expenditure (MET/min/week) distinguishing light (<4 MET), moderate (4-5.5 MET) and vigorous (≥6 MET) PA and recording information about the PA at work and in everyday life and about sedentary behaviors 42 .…”

Section: Methodsmentioning

confidence: 99%

Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plus trial

Daimiel

Martínez‐González

Corella

et al. 2020

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Physical activity (PA) has been hypothesized to be effective to maintaining cognitive function and delay cognitive decline in the elderly, but physical fitness (PF) could be a better predictor of cognitive function. We aimed to study the association between PA and PF with cognitive function and quality of life using cross-sectional data from 6874 participants of the PREDIMED-Plus trial (64.9 ± 4.9 years, 48.5% female). PF and PA were measured with a Chair Stand Test, the REGICOR and Rapid Assessment Physical Activity questionnaires. Cognitive function was measured with Minimental State Examination, Control Oral Word Association Test, Trail Making Test and Digit Span tests; whereas health-related quality of life was assessed with the SF36-HRQL test. Cognitive and quality of life scores were compared among PF quartiles and PA levels (low, moderate and high) with ANCOVA and with Chair Stand repetitions and energy expenditure from total PA with multivariable linear regression adjusted for confounding factors. PF associated with higher scores in phonemic and semantic verbal fluency tests and with lower TMT A time. However, PA was not associated with the neurocognitive parameters evaluated. Both PF and PA levels were strongly associated with a better quality of life. We concluded that PF, but not PA, is associated with a better cognitive function. This trial was retrospectively registered at the International Standard Randomized Controlled Trial (ISRCTN89898870, https://www.isrctn.com/ISRCTN89898870?q=ISRCTN89898870&filters=&sort=&o ffset=1&totalResults=1&page=1&pageSize=10&searchType=basic-search) on 07/24/2014. Scientific RepoRtS | (2020) 10:3472 | https://doi.Cognitive impairment was assessed with the Mini-mental State Examination test (MMSE) and the Clock-Drawing test (CDT) [52][53][54] . The MMSE test is a 30-point questionnaire that examines domains like time and spatial orientation, immediate and deferred recall, attention, calculation, and language. A score is calculated for each domain, and all are added to obtain a total MMSE score. A threshold of 24 is defined to identify cognitive impairment. The CDT is useful to examine visuospatial functioning and memory. Participants are required to draw a clock with a specific time, and a numeric score of 0 or 1 is given depending if they correctly or incorrectly draw the numbers, minute and seconds clock hands and the requested time 49 . All scores are sum to get a total CDT score.All cognitive tests were applied by nutritionists who had been previously trained.

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Section: Methodsmentioning

confidence: 99%

Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plus trial

Daimiel

Martínez‐González

Corella

et al. 2020

Sci Rep

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“…The validated 14-item PREDIMED questionnaire was also used to assess adherence to the traditional MedDiet only in the CG participants (19) (Supplementary Data). A validated 143item food frequency questionnaire was also completed, together with the validated Regicor Short Physical Activity Questionnaire (20) and the validated Spanish version of the Nurses' Health Study questionnaire to assess sedentary behaviors (21). Physical fitness was evaluated using the validated 30-s chair-stand test (22).…”

Section: Randomization and Interventionmentioning

confidence: 99%

Effect of a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet and Exercise on Weight Loss and Cardiovascular Risk Factors: One-Year Results of the PREDIMED-Plus Trial

et al. 2018

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Diabetes Care 2019;42:777-788 | https://doi.org/10.2337/dc18-0836 OBJECTIVEThe long-term impact of intentional weight loss on cardiovascular events remains unknown. We describe 12-month changes in body weight and cardiovascular risk factors in PREvención con DIeta MEDiterránea (PREDIMED)-Plus, a trial designed to evaluate the long-term effectiveness of an intensive weight loss lifestyle intervention on primary cardiovascular prevention. RESEARCH DESIGN AND METHODSOverweight/obese adults with metabolic syndrome aged 55-75 years (n = 626) were randomized to an intensive weight loss lifestyle intervention based on an energyrestricted Mediterranean diet, physical activity promotion, and behavioral support (IG) or a control group (CG). The primary and secondary outcomes were changes in weight and cardiovascular risk markers, respectively. RESULTSDiet and physical activity changes were in the expected direction, with significant improvements in IG versus CG. After 12 months, IG participants lost an average of 3.2 kg vs. 0.7 kg in the CG (P < 0.001), a mean difference of 22.5 kg (95% CI 23.1 to 21.9). Weight loss ‡5% occurred in 33.7% of IG participants compared with 11.9% in the CG (P < 0.001). Compared with the CG, cardiovascular risk factors, including waist circumference, fasting glucose, triglycerides, and HDL cholesterol, significantly improved in IG participants (P < 0.002). Reductions in insulin resistance, HbA 1c , and circulating levels of leptin, interleukin-18, and MCP-1 were greater in IG than CG participants (P < 0.05). IG participants with prediabetes/diabetes significantly improved glycemic control and insulin sensitivity, along with triglycerides and HDL cholesterol levels compared with their CG counterparts. CONCLUSIONSPREDIMED-Plus intensive lifestyle intervention for 12 months was effective in decreasing adiposity and improving cardiovascular risk factors in overweight/obese older adults with metabolic syndrome, as well as in individuals with or at risk for diabetes.Clinical trial reg. no. ISRCTN89898870, www .isrctn.org This article contains Supplementary Data online at

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“…Fasting plasma glucose, total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride concentrations were measured as previously described [107]. Leisure-time physical activity was assessed using the validated REGICOR questionnaire [108], including questions to collect information on the type of activity, frequency (number of days), duration, and total leisure-time physical activity-related energy expenditure was estimated. The dietary pattern was assessed by a 17-item score capturing adherence to a traditional Mediterranean diet [109].…”

Section: Baseline Clinical Anthropometric Biochemical and Lifestylmentioning

confidence: 99%

Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome

et al. 2020

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Many early studies presented beneficial effects of polyunsaturated fatty acids (PUFA) on cardiovascular risk factors and disease. However, results from recent meta-analyses indicate that this effect would be very low or nil. One of the factors that may contribute to the inconsistency of the results is that, in most studies, genetic factors have not been taken into consideration. It is known that fatty acid desaturase (FADS) gene cluster in chromosome 11 is a very important determinant of plasma PUFA, and that the prevalence of the single nucleotide polymorphisms (SNPs) varies greatly between populations and may constitute a bias in meta-analyses. Previous genome-wide association studies (GWAS) have been carried out in other populations and none of them have investigated sex and Mediterranean dietary pattern interactions at the genome-wide level. Our aims were to undertake a GWAS to discover the genes most associated with serum PUFA concentrations (omega-3, omega-6, and some fatty acids) in a scarcely studied Mediterranean population with metabolic syndrome, and to explore sex and adherence to Mediterranean diet (MedDiet) interactions at the genome-wide level. Serum PUFA were determined by NMR spectroscopy. We found strong robust associations between various SNPs in the FADS cluster and omega-3 concentrations (top-ranked in the adjusted model: FADS1-rs174547, p = 3.34 × 10−14; FADS1-rs174550, p = 5.35 × 10−14; FADS2-rs1535, p = 5.85 × 10−14; FADS1-rs174546, p = 6.72 × 10−14; FADS2-rs174546, p = 9.75 × 10−14; FADS2-rs174576, p = 1.17 × 10−13; FADS2-rs174577, p = 1.12 × 10−12, among others). We also detected a genome-wide significant association with other genes in chromosome 11: MYRF (myelin regulatory factor)-rs174535, p = 1.49 × 10−12; TMEM258 (transmembrane protein 258)-rs102275, p = 2.43 × 10−12; FEN1 (flap structure-specific endonuclease 1)-rs174538, p = 1.96 × 10−11). Similar genome-wide statistically significant results were found for docosahexaenoic fatty acid (DHA). However, no such associations were detected for omega-6 PUFAs or linoleic acid (LA). For total PUFA, we observed a consistent gene*sex interaction with the DNTTIP2 (deoxynucleotidyl transferase terminal interacting protein 2)-rs3747965 p = 1.36 × 10−8. For adherence to MedDiet, we obtained a relevant interaction with the ME1 (malic enzyme 1) gene (a gene strongly regulated by fat) in determining serum omega-3. The top-ranked SNP for this interaction was ME1-rs3798890 (p = 2.15 × 10−7). In the regional-wide association study, specifically focused on the FADS1/FASD2/FADS3 and ELOVL (fatty acid elongase) 2/ELOVL 5 regions, we detected several statistically significant associations at p < 0.05. In conclusion, our results confirm a robust role of the FADS cluster on serum PUFA in this population, but the associations vary depending on the PUFA. Moreover, the detection of some sex and diet interactions underlines the need for these associations/interactions to be studied in all specific populations so as to better understand the complex metabolism of PUFA.

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Validation of the Regicor Short Physical Activity Questionnaire for the Adult Population

Cited by 146 publications

References 30 publications

Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plus trial

Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plus trial

Effect of a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet and Exercise on Weight Loss and Cardiovascular Risk Factors: One-Year Results of the PREDIMED-Plus Trial

Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome

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