Validation of the Lille's Apathy Rating Scale in Very Mild to Moderate Dementia

Fernández‐Matarrubia, Marta; Matías‐Guiu, Jordi A.; Moreno‐Ramos, Teresa; Valles‐Salgado, María; Marcos-Dolado, Alberto; García-Ramos, R.

doi:10.1016/j.jagp.2015.09.004

Cited by 19 publications

(26 citation statements)

References 44 publications

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“…By contrast, the LARS is a multidimensional scale composed of 33 items, subdivided into nine subscales, grouped into four factors. Moreover, this scale is consistent with the recent international consensus criteria for the diagnosis of apathy . The LARS is supported by the principles of Marin and Stuss et al and takes the pathophysiological processes of apathy into account .…”

Section: Discussionsupporting

confidence: 81%

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The impact of apathy on cognitive performance in the elderly

Montoya-Murillo

Ibarretxe‐Bilbao

Peña

et al. 2019

Int J Geriat Psychiatry

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Objectives To examine the impact of apathy on cognitive performance in the elderly following the conceptual principles proposed by Marin 1 and Stuss et al 2 and to determine the role of the symptoms of apathy in different cognitive domains. Methods Cross‐sectional study with a cohort of healthy elderly subjects over 55 years old (n = 140). One hundred forty healthy‐elderly subjects (aged 79.24 ± 8.6 years old) were recruited from 12 day centers in Northern Spain. Participants underwent a neuropsychological battery, which evaluated Mini Mental State Examination (MMSE), attention, processing speed, verbal fluency, visual and verbal memory, working memory, and executive functioning. Apathy was assessed by the Lille Apathy Rating Scale (LARS), which is composed of four factors: intellectual curiosity, emotion, action initiation, and self‐awareness. Correlation and linear regression analyses were performed. Results In the correlational analysis, the LARS total score correlated negatively with global cognition, verbal fluency, and visual and verbal memory. The intellectual curiosity factor correlated negatively with all cognitive domains except attention. The emotion factor correlated negatively with visual memory. No correlation was found between the action initiation and self‐awareness factors or any of the cognitive variables. Multiple stepwise regression analysis showed that symptoms of apathy explained cognitive performance in attention, processing speed, verbal fluency, visual and verbal memory, working memory, executive functioning, and MMSE. Conclusions Apathy was significantly associated with cognitive performance, especially with the intellectual curiosity factor. Our results suggest that specific symptoms of apathy contribute differently to individual cognitive domains.

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Section: Discussionsupporting

confidence: 81%

“…Some authors have considered the LARS as the best adapted scale for evaluating apathy in noninstitutionalized elderly people. 4 Table S1 to see review). 3,[9][10][11] In addition, apathy has been suggested to be a risk factor for progression to AD.…”

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confidence: 99%

The impact of apathy on cognitive performance in the elderly

Montoya-Murillo

Ibarretxe‐Bilbao

Peña

et al. 2019

Int J Geriat Psychiatry

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“…However, studies looking at medication effects on apathy are sparse and report mixed results, with no studies looking directly at the effect on apathy subtypes [60]. Finally, while sample size (AD patient = 55 and Carer = 102) of this study could be cited as a limitation, however previous studies validating and utilizing apathy measurement methods in dementia had similar or smaller sample sizes than our current study, examples include the LARS [23], NPI [16], AES [19] and AI [24]. However, use of the DAS in larger samples of dementia patients would further the understanding of multidimensional apathy in dementia.…”

Section: Discussionmentioning

confidence: 69%

“…The Scale for Assessment for Negative Symptoms [22] is also less commonly used measure of different types of negative symptoms, affective blunting, avolition/apathy and social/emotional withdrawal, which have overlap with some apathy subtypes. More recently, Lille Apathy Rating Scale (LARS) has been validated in a group of mixed dementia patients [23] but measures uncorroborated factorial subscores of apathy.…”

Section: Introductionmentioning

confidence: 99%

A Novel Assessment and Profiling of Multidimensional Apathy in Alzheimer’s Disease

Radaković

Starr

Abrahams

2017

JAD

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“…The LARS includes 33 items grouped in nine domains or subscales (“Reduction in everyday productivity,” “Lack of interest,” “Lack of initiative,” “Extinction of novelty seeking,” “Motivation,” “Blunting of emotional responses,” “Lack of concern,” “Poor social life,” and “Extinction of self‐awareness”) that can be combined to calculate four factors or dimensions of apathy: “intellectual curiosity,” “emotion,” “action initiation,” and “self‐awareness” (Sockeel et al, ). Our group have recently published the validation of the LARS in a dementia cohort, which demonstrated excellent psychometric properties (Fernández‐Matarrubia et al, ).…”

Section: Introductionmentioning

confidence: 99%

Different apathy clinical profile and neural correlates in behavioral variant frontotemporal dementia and Alzheimer's disease

Fernández‐Matarrubia

Matías‐Guiu

Cabrera‐Martín

et al. 2017

Int J Geriat Psychiatry

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Objectives: Apathy is one of the most common and disabling syndromes of dementia. Clinical apathy expression and neuroanatomical basis of apathy seem to differ between behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD), although evidence is scarce and poorly understood. Our main purposes were to compare the clinical apathy profile from patients with bvFTD and AD and analyze the relationship between apathy and brain metabolism measured using positron emission tomography imaging with 18 F fluorodeoxyglucose (FDG-PET). Methods: Forty-two bvFTD, 42 AD, and 30 healthy volunteers without cognitive or behavioral complaints were included. Apathy was defined using Robert's 2009 diagnostic criteria, and specific apathy characteristics were assessed with the Lille Apathy Rating Scale. All participants underwent FDG-PET brain scan to provide data for voxel-based morphometric analysis. Results: Multivariate analysis showed that subjects affected by bvFTD displayed greater impairment of emotional apathy and self-awareness in comparison with AD sample. Additionally, FDG-PET imaging analyses revealed that apathy was associated with different neuroanatomical substrates in each dementia group: left lateral prefrontal, medial frontal/anterior cingulate, lateral orbitofrontal and anterior insular cortices in bvFTD, and right anterior cingulate in AD. Conclusions: These results support that apathy is a complex syndrome, with different clinical expressions across different pathological conditions. Those differences in qualitative aspects of apathy seem to be associated with differences in the damage sites, as shown by our FDG-PET imaging analysis. Our findings provide a better knowledge about pathophysiology of apathy in dementia, which could have practical implications for therapeutic management.

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Validation of the Lille's Apathy Rating Scale in Very Mild to Moderate Dementia

Cited by 19 publications

References 44 publications

The impact of apathy on cognitive performance in the elderly

The impact of apathy on cognitive performance in the elderly

A Novel Assessment and Profiling of Multidimensional Apathy in Alzheimer’s Disease

Different apathy clinical profile and neural correlates in behavioral variant frontotemporal dementia and Alzheimer's disease

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