Validation of the Italian version of the Non Motor Symptoms Scale for Parkinson's disease

Cova, Ilaria; Battista, Maria Elena Di; Vanacore, Nicola; Papi, Chiara; Alampi, G.; Rubino, Alfonso; Valente, Mariarosaria; Meco, Giuseppe; Contri, P.; Pucchio, Alessandra Di; Lacorte, Eleonora; Mariani, Claudio; Pomati, Simone

doi:10.1016/j.parkreldis.2016.10.020

Cited by 37 publications

(44 citation statements)

References 25 publications

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“… 23 In addition, brain magnetic resonance imaging was performed on almost all patients, revealing normal findings in the patients with PD+OH, but typical abnormalities that support the clinical diagnosis in most patients with MSA‐P (ie, putaminal atrophy and hyperintense putaminal rim, hot‐cross bun sign, and brainstem atrophy) 23,24 . Clinical involvement was quantified with specific questionnaires for autonomic (ie, COMPASS‐31 25 ), motor (Unified Parkinson's Disease Rating Scale Part III and Hoehn and Yahr scores) and nonmotor (Non‐Motor Symptoms Scale 26 ) dysfunction, and a focused scale for MSA (Unified MSA Rating Scale [UMSARS‐I and UMSARS‐II 27 ]; Table 1). The presence of rapid eye movement sleep behavior disorder was reported by bed partners frequent enacted dreams.…”

Section: Methodsmentioning

confidence: 99%

Skin Biopsy May Help to Distinguish Multiple System Atrophy–Parkinsonism from Parkinson's Disease With Orthostatic Hypotension

et al. 2020

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Background The differential diagnosis between multiple system atrophy parkinsonism type (MSA‐P) and Parkinson's disease with orthostatic hypotension (PD+OH) is difficult because the 2 diseases have a similar clinical picture. The aim of this study is to distinguish MSA‐P from PD+OH by immunostaining for abnormal phosphorylated α‐synuclein at serine 129 (p‐syn) in cutaneous nerves. Method We recruited 50 patients with parkinsonism and chronic orthostatic hypotension: 25 patients fulfilled the diagnostic criteria for MSA‐P and 25 patients for PD+OH. The patients underwent a skin biopsy from the cervical area, thigh, and leg to analyze somatic and autonomic skin innervation and p‐syn in skin nerves. Results Intraneural p‐syn positivity was found in 72% of patients with MSA‐P, mainly in distal skin sites. More important, p‐syn deposits in MSA‐P differed from PD+OH because they were mainly found in somatic fibers of subepidermal plexi, whereas scant autonomic fiber involvement was found in only 3 patients. All patients with PD+OH displayed widely distributed p‐syn deposits in the autonomic skin fibers of proximal and distal skin sites, whereas somatic fibers were affected only slightly in 4 patients with PD+OH. Skin innervation mirrored p‐syn deposits because somatic innervation was mainly reduced in MSA‐P. Sympathetic innervation was damaged in PD+OH but fairly preserved in MSA‐P. Conclusions The p‐syn in cutaneous nerves allows the differentiation of MSA‐P from PD+OH; MSA‐P mainly shows somatic fiber involvement with relatively preserved autonomic innervation; and by contrast, PD+OH displays prevalent abnormal p‐syn deposits and denervation in autonomic postganglionic nerves. © 2020 International Parkinson and Movement Disorder Society

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Section: Methodsmentioning

confidence: 99%

Skin Biopsy May Help to Distinguish Multiple System Atrophy–Parkinsonism from Parkinson's Disease With Orthostatic Hypotension

et al. 2020

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“…19 Cases and matched controls underwent in-depth assessment using internationally validated scales. Motor aspects of experiences of daily living and the severity of treatment-related motor complications were assessed using the Movement Disorders Society Unified PD Rating Scale (MDS-UPDRS) Parts II and IV, respectively 20 ; nonmotor symptoms were assessed using of the Italian version of the Non-Motor Symptoms Scale (NMSS) 21 ; and overall changes of motor and nonmotor features were additionally rated using the Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD). 22 Descriptive statistics were provided for continuous (mean and standard deviation) and categorical (count and percentage) variables, which were compared between groups using Student's t test and Fisher's exact test.…”

Section: ---------------------------------------------------------mentioning

confidence: 99%

Effects of COVID‐19 on Parkinson's Disease Clinical Features: A Community‐Based Case‐Control Study

et al. 2020

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The impact of coronavirus disease 2019 (COVID-19) on clinical features of Parkinson's disease (PD) has been poorly characterized so far. Of 141 PD patients resident in Lombardy, we found 12 COVID-19 cases (8.5%), whose mean age and disease duration (65.5 and 6.3 years, respectively) were similar to controls. Changes in clinical features in the period January 2020 to April 2020 were compared with those of 36 PD controls matched for sex, age, and disease duration using the clinical impression of severity index for PD, the Movement Disorders Society Unified PD Rating Scale Parts II and IV, and the nonmotor symptoms scale. Motor and nonmotor symptoms significantly worsened in the COVID-19 group, requiring therapy adjustment in one third of cases. Clinical deterioration was explained by both infection-related mechanisms and impaired pharmacokinetics of dopaminergic therapy. Urinary issues and fatigue were the most prominent nonmotor issues. Cognitive functions were marginally involved, whereas none experienced autonomic failure.

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“…Over the last few years, the interest for evaluating both motor and non-motor symptoms of PD is increasing in Italy. Italian health professionals and researchers can now use different assessment tools, such as the Parkinson's Disease Questionnaire 39 8 , the Non Motor Symptoms Scale 9 , the Parkinson's Disease-Cognitive Rating Scale 10 , Freezing of Gait Questionnaire 11 and the Geriatric Depression Scale 12 .…”

Section: Introductionmentioning

confidence: 99%

Validity and reliability of the 12-item Berg Balance Scale in an Italian population with Parkinson’s disease: A cross sectional study

Berardi

Valente

Conte

et al. 2020

Arq. Neuro-Psiquiatr.

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ABSTRACT Background: The Berg Balance Scale is widely used to measure balance ability in clinical practice. Recently, the original version was redefined from 14 into 12 items. Its psychometric properties were investigated for different populations. However, for Parkinson disease the new version has not been validated yet. Objective: The purpose of the present study was to evaluate psychometric properties of the 12-item Berg Balance Scale (BBS-12) in a population with Parkinson disease. Methods: Internal consistency was evaluated with Cronbach’s alpha coefficient, whereas reliability was assessed with the intraclass correlation coefficient. For validity analysis, the Pearson correlation coefficient of the BBS-12 was evaluated with the Tinetti Scale and the Physical Activity Scale for the Elderly. Results: The BBS-12 was applied to 50 individuals with a mean age of 65.6 years (SD 11.8). The internal consistency showed a good value (Cronbach's alpha 0.886) and reproducibility reveled very high performances for both inter-rater and intra-rater reliabilities (ICC 0.987 and 0.986, respectively). The validity study demonstrated good linear correlation with the Tinetti Scale (p<0.01) and with the Sport and Home Subscales of the Physical Activity Scale for the Elderly (p<0.01). Conclusions: The present findings revealed the BBS-12 as a reliable and valid assessment tool to measure balance ability in Parkinson disease. Italian health professionals can now use it with more confidence.

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Validation of the Italian version of the Non Motor Symptoms Scale for Parkinson's disease

Abstract: The Italian NMSS is a comprehensive and helpful measure for NMS in native Italian patients with PD.

Cited by 37 publications

References 25 publications

Skin Biopsy May Help to Distinguish Multiple System Atrophy–Parkinsonism from Parkinson's Disease With Orthostatic Hypotension

Skin Biopsy May Help to Distinguish Multiple System Atrophy–Parkinsonism from Parkinson's Disease With Orthostatic Hypotension

Effects of COVID‐19 on Parkinson's Disease Clinical Features: A Community‐Based Case‐Control Study

Validity and reliability of the 12-item Berg Balance Scale in an Italian population with Parkinson’s disease: A cross sectional study

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