Background: Clinical practice is a demanding academic activity for nursing students, and a variety of factors can affect this perception. This study aimed to investigate the predictors of perceived stress among Indonesian nursing students during their clinical practice. Methods: From September to November 2022, this cross-sectional investigation was carried out. Five questionnaires, including the socio-demographic, the PSS, the GHQ, the CBI, the MSPSS and the RSES, were completed by 208 participants. With significance set to p < 0.05, the Pearson correlation and multiple linear regression analysis were carried out. Results: Coping strategies ( r = 0.20, p < 0.01), overall health ( r = 0.50, p < 0.01), social support ( r = −0.34, p < 0.01) and self-esteem ( r = −0.51, p < 0.01) were all substantially linked with perceived stress. Furthermore, age (β = −0.22, p < 0.001), coping style (β = 0.22, p < 0.001) and self-esteem (β = −0.42, p < 0.001) substantially predicted perceived stress among nursing students. Conclusion: The study’s findings revealed strong relationships between perceived stress and general health, coping mechanisms, self-esteem and social support. These results can be utilised as evidence to help educators and other stakeholders develop programmes that effectively manage stress among nursing students during their clinical rotations.