Validation of the Critical-Care Pain Observation Tool-Neuro in brain-injured adults in the intensive care unit: a prospective cohort study

Gélinas, Céline; Bérubé, Mélanie; Puntillo, Kathleen; Boitor, Mădălina; Richard-Lalonde, Melissa; Bernard, Francis; Williams, Virginie; Joffe, Aaron M.; Steiner, Craig; Marsh, Rebekah; Rose, Louise; Dale, Craig; Tsoller, Darina M.; Choinière, Manon; Streiner, David L.

doi:10.1186/s13054-021-03561-1

Cited by 12 publications

(5 citation statements)

References 51 publications

(23 reference statements)

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“…A minimal sample size of 10 participants per group is recommended in pilot studies [ 25 , 26 ]. Because studies with repeated measures (such as crossover designs) require more time commitment from participants (ie, multiple measurements over time), an attrition rate of approximately 15% (n=2 per group) can be anticipated, which is consistent with what has been reported in previous studies conducted in the targeted population [ 27 , 28 ]. To account for this, the recruited sample size was estimated to be 12 participants per group.…”

Section: Methodssupporting

confidence: 76%

Acceptability and Feasibility of a Patient-Oriented Music Intervention to Reduce Pain in the Intensive Care Unit: Protocol for a Crossover Pilot Randomized Controlled Trial

Richard-Lalonde¹,

Feeley²,

Cossette³

et al. 2023

JMIR Res Protoc

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Background Many patients experience pain in the intensive care unit (ICU) despite receiving pain medication. Research has shown that music can help reduce pain. Music interventions studied so far have not used music streaming to generate playlists based on patient preferences while incorporating recommended tempo and duration. Previous research has focused on postoperative ICU patients able to self-report, which is underrepresentative of the ICU population that might benefit from a music intervention for pain management. We developed a new patient-oriented music intervention (POMI) that incorporates features based on theoretical, empirical, and experiential data intended to be used in the ICU. Such a music intervention should consider the expertise of ICU patients, family members, and nursing staff, as well as the practicality of the intervention when used in practice. Objective The primary objectives of this study are to (1) evaluate the acceptability and feasibility of the POMI to reduce pain in ICU patients and (2) evaluate the feasibility of conducting a crossover pilot randomized controlled trial (RCT) for intervention testing in the ICU. A secondary objective is to examine the preliminary efficacy of the POMI to reduce pain in ICU patients. Methods A single-blind 2×2 crossover pilot RCT will be conducted. Patients will undergo 1 sequence of 2 interventions: the POMI which delivers music based on patients’ preferences via headphones or music pillow for 20-30 minutes and the control intervention (headphones or pillow without music). The sequence of the interventions will be inverted with a 4-hour washout period. Timing of the interventions will be before a planned bed turning procedure. Each patient will undergo 1 session of music. Twenty-four patients will be recruited. Patients able to self-report (n=12), family members of patients unable to self-report (n=12), and nursing staff (n=12) involved in the bed turning procedure will be invited to complete a short questionnaire on the POMI acceptability. Data will be collected on the feasibility of the intervention delivery (ie, time spent creating a playlist, any issue related to headphones/pillow or music delivery, environmental noises, and intervention interruptions) and research methods (ie, number of patients screened, recruited, randomized, and included in the analysis). Pain scores will be obtained before and after intervention delivery. Results Recruitment and data collection began in March 2022. As of July 5, 2022, in total, 22 patients, 12 family members, and 11 nurses were recruited. Conclusions Methodological limitations and strengths are discussed. Study limitations include the lack of blinding for patients able to self-report. Strengths include collecting data from various sources, getting a comprehensive evaluation of the intervention, and using a crossover pilot RCT design, where participants act as their own control, thus reducing confounding factors. Trial Registration ClinicalTrials.gov NCT05320224; https://clinicaltrials.gov/ct2/show/NCT05320224 International Registered Report Identifier (IRRID) DERR1-10.2196/40760

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Section: Methodssupporting

confidence: 76%

Acceptability and Feasibility of a Patient-Oriented Music Intervention to Reduce Pain in the Intensive Care Unit: Protocol for a Crossover Pilot Randomized Controlled Trial

Richard-Lalonde¹,

Feeley²,

Cossette³

et al. 2023

JMIR Res Protoc

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“…The severity of articular cartilage, meniscus, ligament, or tendon lesions was analyzed and compared using nonparametric tests of two independent samples. P < 0.05 considered the difference to be statistically significant [ 16 ].…”

Section: Experimental Analysismentioning

confidence: 99%

Observation on the Effect of MRI Image Scanning on Knee Pain in Football Injury

Wei-dong

2022

Scanning

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To study the effect of football injury on knee pain based on MRI image scanning, in this paper, a total of 31 knee injuries of 29 male professional football players from December 2012 to April 2015 were used as the experimental group. The players were 23.6 ± 3.5 years old and received professional football training time 15.3 ± 3.6 years; 31 outpatients of the same age group with acute knee joint acute injury were randomly selected as the control group; both groups were imaged with a 1.5 TMR scanner and knee joint standard array coil imaging, and 2 senior radiation surgeons evaluate knee cartilage, meniscus, ligaments, tendons, bone marrow, infrapatellar fat pad, and joint effusions. Pearson’s chi-squared test and nonparametric test for two independent samples were used for statistical testing of the evaluation results. The experimental results showed that there were significant differences in the incidence of articular cartilage, lateral collateral ligament, tendon or ligament injury, multiligament or tendon injury, and bone marrow edema between the two groups ( P < 0.05 ). There was no significant difference in the incidence of medial collateral ligament injury, infrapatellar fat pad edema, and joint effusion. MRI shows that knee injuries in male professional football players often involve ligaments or tendons, mostly multiligament or tendon injuries. The lesions of articular cartilage and meniscus are more common and serious, and bone marrow edema is also more common in football injuries. MRI has high diagnostic accuracy for various clinical knee injuries, and it belongs to a noninvasive examination method. It can not only reflect the pathological changes and changes of the knee joints of patients but also provide information for the formulation of clinical programs and the judgment of prognosis, for timely, accurate, and comprehensive imaging reference.

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“…The CPOT has recently been adapted to better represent behaviours relevant to brain-injured ICU patients [10]. The CPOT and CPOT-Neuro have similar scoring systems with content specific to the patient's condition.…”

Section: Patients Unable To Self-report: Observational Behavioural Sc...mentioning

confidence: 99%

Monitoring pain in the intensive care unit (ICU)

Chanques

Gélinas

2022

Intensive Care Med

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Validation of the Critical-Care Pain Observation Tool-Neuro in brain-injured adults in the intensive care unit: a prospective cohort study

Cited by 12 publications

References 51 publications

Acceptability and Feasibility of a Patient-Oriented Music Intervention to Reduce Pain in the Intensive Care Unit: Protocol for a Crossover Pilot Randomized Controlled Trial

Acceptability and Feasibility of a Patient-Oriented Music Intervention to Reduce Pain in the Intensive Care Unit: Protocol for a Crossover Pilot Randomized Controlled Trial

Observation on the Effect of MRI Image Scanning on Knee Pain in Football Injury

Monitoring pain in the intensive care unit (ICU)

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