Validation of the Children’s International Mucositis Evaluation Scale (ChIMES) in paediatric cancer and SCT

Abstract

Background:Objectives were to describe the reliability and validity of a new paediatric-specific mucositis scale, the Children's International Mucositis Evaluation Scale (ChIMES).Methods:In a multi-centre prospective study, children aged 0 to ⩽18 years were eligible if they were receiving any of the following: myeloablative stem cell transplantation (SCT), ⩾60 mg m−2 course−1 doxorubicin or ⩾12 g m−2 methotrexate. Multiple measures of mucositis were included along with ChIMES. Respondents were parent proxy report for children aged <12 years, and child self-report for children aged 12–18 years and 8 to <12 years. Mucositis diaries were completed at baseline and on Days 7–17 following chemotherapy/conditioning. On Day 14, the respondent reported presence of mucositis and change since the previous day.Results:The 185 respondents included parents (N=98), children aged 12–18 years (N=66) and children aged 8 to <12 years (N=21). Test–retest reliability was excellent for ChIMES Total Score and ChIMES Percentage Score with r>0.8 for all respondent types. Criteria for construct validation were met across all measures. ChIMES also demonstrated responsiveness with significant differences between baseline and Day 14.Conclusion:ChIMES is a paediatric-specific measure of mucositis with favourable psychometric properties. It exhibits reliability, construct validity and responsiveness. ChIMES should be incorporated into clinical trials of mucositis prevention and treatment in paediatric cancer and SCT.

Validity and Reliability of the Oral Assessment Guide for Children and Young People Receiving Chemotherapy

“…This is essential for an instrument to be used in clinical practice and research. [33] In the original CVI to be high (ranging from [16], which was in parallel with the finding of this study. All items of the Turkish scale sufficiently correlated with the total score and had a high level of item reliability.…”

“…It also reflected the construct validity of the scale. [32,33] The literature includes a limited number of studies that aim to develop oral assessment scales for children with cancer who receive chemotherapy. [15,16,19,34] Only one study is available in Turkey regarding the oral assessment scales for children with cancer who receive chemotherapy.…”

The Children's International Mucositis Evaluation Scale Is Valid and Reliable for the Assessment of Mucositis Among Brazilian Children With Cancer

“…The maximum total score is 23. 2 Translation and Cultural Adaptation. Translation and cultural adaptation of ChIMES were performed according to the standards formulated by Beaton et al 14 (Fig.…”

“…The VAS consists of a 10 cm horizontal line; the ends represent scores of 0 (no pain in the mouth or throat) and 10 (worst possible pain in the mouth or throat). 2 Common Terminology Criteria for Adverse Events. CTCAE assesses oral mucositis from the clinical and functional/symptomatic perspectives; the score ranges from 0 to 5.…”

Supportive Care in Pediatric Oncology

“…11.3 ), an assessment instrument for both child selfreport and parent proxy-report (Tomlinson et al 2009 ). ChIMES has been shown to be understandable, with content validity and acceptability, and has been prospectively validated in a multicenter cohort of children receiving chemotherapy and after HSCT (Tomlinson et al 2009(Tomlinson et al , 2011Jacobs et al 2013 ). ChIMES has been shown to be understandable, with content validity and acceptability, and has been prospectively validated in a multicenter cohort of children receiving chemotherapy and after HSCT (Tomlinson et al 2009(Tomlinson et al , 2011Jacobs et al 2013 ).…”