Validation of the cerebellum as a reference region for SPECT quantification in patients suffering from dementia of the Alzheimer type

Pickut, Barbara A.; Dierckx, Rudi; Dobbeleir, André; Audenaert, Kurt; Laere, Koen Van; Vervaet, A.; Deyn, Peter Paul De

doi:10.1016/s0925-4927(99)00004-9

Cited by 45 publications

(34 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mean global cerebral perfusion in AD patients may be quite different from that in normal subjects. On the other hand, as Pickut et al [16]reported, the cerebellum remains scintigraphically uninvolved in the presence of 99m Tc-HMPAO SPECT in AD patients. Thus, we used the cerebellum as a reference region for image intensity normalization.…”

Section: Discussionmentioning

confidence: 97%

Statistical Parametric Mapping of Brain SPECT Perfusion Abnormalities in Patients with Alzheimer’s Disease

Lee

Liu²,

Liao

et al. 2003

Eur Neurol

View full text Add to dashboard Cite

Brain perfusion in 20 patients with mild Alzheimer’s disease (AD), 20 patients with moderate AD and 20 control subjects (matched for age, gender and education) were assessed by single photon emission computed tomography (SPECT) using technetium-99m hexamethylpropylene amine oxime (^99mTc-HMPAO). SPECT images were transformed to a standard size and shape for group comparisons by the voxel-based t test of the statistical parametric mapping techniques. Cerebral hypoperfusion in the left lower parietal area was found in mild AD patients. In moderate AD patients, significant cerebral hypoperfusion was located in bilateral posterior parietotemporal cortices, contiguous anterior occipital lobes, posterior cingulate gyri and, to a lesser extent, in frontal areas.

show abstract

Section: Discussionmentioning

confidence: 97%

Statistical Parametric Mapping of Brain SPECT Perfusion Abnormalities in Patients with Alzheimer’s Disease

Lee

Liu²,

Liao

et al. 2003

Eur Neurol

View full text Add to dashboard Cite

show abstract

“…The cerebellum activities were calculated with the template method reported by Soonawala et al [25] who established the validity of using cerebellum as the reference region for AD patients. Although the presence of plaques and neurofi brillary tangles in the cerebellum had been reported, SPECT studies showed that the cerebellum was scintigraphically unaffected before the advanced stage of AD [26,27] .…”

Section: Spect Imaging and The Spm Methodsmentioning

confidence: 99%

Cognitive Reserve: A SPECT Study of 132 Alzheimer’s Disease Patients with an Education Range of 0–19 Years

Liao

Liu

Teng

et al. 2005

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

This study examines the associations between education, cerebral perfusion, and cognitive test performance among 132 patients with Alzheimer’s disease. The participants had had between 0 and 19 years of formal schooling, and had either mild or moderate dementia according to the Clinical Dementia Rating Scale. Cerebral perfusion was evaluated by the ^99mTc-hexamethylpropylene amine oxime single photon emission computed tomography. The Mini-Mental State Examination and the Cognitive Abilities Screening Instrument were used to assess cognitive performance. For patients at each clinical dementia severity level, statistical parametric mapping was used to examine voxel by voxel the association between education and cerebral perfusion, and Pearson’s correlation coefficients were calculated between education and cognitive test scores. Years of formal schooling had negative associations with cerebral perfusion and positive associations with cognitive test scores. The brain regions showing a significant education effect on perfusion involved bilateral posterior association areas in mild dementia, and bilateral parieto-temporo-frontal areas in moderate dementia. The present findings indicate that the cognitive reserve effect starts at the low end of the education range. They also suggest that the main effect of more education is a more facile use of alternative brain circuits instead of locally increased synaptic connections.

show abstract

“…The validity of using the cerebellum as a reference region in AD patients has been previously established [21]. Although other regions, such as the occipital lobes [22] and pons [23], have been suggested as alternatives to the cerebellum, these regions are not uncommonly affected in AD (e.g.…”

Section: Methodsmentioning

confidence: 99%

Limbic system perfusion in Alzheimer's disease measured by MRI-coregistered HMPAO SPET

2002

View full text Add to dashboard Cite

The goal of this study was to perform a systematic, semi-quantitative analysis of limbic perfusion in patients with Alzheimer's disease (AD) using coregistered single-photon emission tomography (SPET) images aligned to magnetic resonance (MR) images. Limbic perfusion in 40 patients with mild to moderate AD was compared with that of 17 age-, sex-, and education-matched normal controls (NC). HMPAO SPET scans and 3D T1-weighted MR images were acquired for each subject. Structures of the limbic system (i.e. hippocampus, amygdala, anterior thalamus, hypothalamus, mamillary bodies, basal forebrain, septal area and cingulate, orbitofrontal and parahippocampal cortices) were traced on the MR images and transferred to the coregistered SPET scans. Perfusion ratios for all limbic regions were calculated relative to cerebellar perfusion. General linear model multivariate analysis revealed that, overall, limbic structures showed significant hypoperfusion (F=7.802, P<0.00001, eta (2)=0.695 ) in AD patients compared with NC. Greatest differences (d > or = 0.8) were found in the hippocampus, as well as all areas of the cingulate cortex. Significant relative hypoperfusion was also apparent in the parahippocampal cortex, amygdala/entorhinal cortex, septal area and anterior thalamus, all of which showed medium to large effect sizes (d=0.6-0.8). No significant relative perfusion differences were detected in the basal forebrain, hypothalamus, mamillary bodies or orbitofrontal cortex. Logistic regression indicated that posterior cingulate cortex perfusion was able to discriminate AD patients from NC with 93% accuracy (95% sensitivity, 88% specificity). The current results suggest that most, but not all, limbic structures show significant relative hypoperfusion in AD. These findings validate previous post-mortem studies and could be useful in improving diagnostic accuracy, monitoring disease progression and evaluating potential treatment strategies in AD.

show abstract

Validation of the cerebellum as a reference region for SPECT quantification in patients suffering from dementia of the Alzheimer type

Cited by 45 publications

References 16 publications

Statistical Parametric Mapping of Brain SPECT Perfusion Abnormalities in Patients with Alzheimer’s Disease

Statistical Parametric Mapping of Brain SPECT Perfusion Abnormalities in Patients with Alzheimer’s Disease

Cognitive Reserve: A SPECT Study of 132 Alzheimer’s Disease Patients with an Education Range of 0–19 Years

Limbic system perfusion in Alzheimer's disease measured by MRI-coregistered HMPAO SPET

Contact Info

Product

Resources

About