Abstract
Background the study was aimed to evaluate the outcomes following implementation of enhanced recovery after surgery (ERAS) in patients undergoing lung cancer surgery.Method a retrospective cohort study with 1,749 patients with lung cancer undergoing pulmonary resection was conducted. Two time period of the patients were included for analyzing (routine pathway and ERAS pathway). Logistic regression analysis and nomogram model was created respectively to assess the risks of postoperative pulmonary complications.Results Among those 1,749 patients, 691 of them was stratified into ERAS group, compared to 1,058 in routine group. ERAS group presented shorter postoperative in-hospital length of stay (LOS) (4.0 vs 6.0, P<0.001), total LOS (10.0 VS. 13.0 days, P<0.001), lower total in-hospital cost (P<0.001) including material (P<0.001), and drug expense (P<0.001). Meanwhile, ERAS group presented lower occurrence of postoperative pulmonary complications (PPCs) compared to routine group (15.2% vs. 19.5%, P=0.022). Likewise, a significantly lower occurrence of pneumonia (8.4% vs. 14.2%, P<0.001) or atelectasis (5.9% vs. 9.8%, P=0.004) was found in ERAS group. Regarding to Binary logistic regression, ERAS intervention was the independent factor for the occurrence of PPCs (OR: 0.601, 95%CI: 0.434-0.824, P=0.002). In addition, age (OR: 1.032, 95%CI: 1.018-1.046), COPD (OR: 1.792, 95%CI: 1.196-2.686), and FEV1(OR: 0.205, 95%CI: 0.125-0.339) were independent predictors for PPCs. A nomogram with a C-index of 0.663 was constructed.Conclusion implementation of an ERAS pathway shows improved postoperative outcomes including shortened LOS, less in-hospital cost, and reduced occurrence of PPCs, providing benefits of postoperative recovery for patients with lung cancer undergoing surgical treatment.Clinical registration number: ChiCTR1900022478