Validation of the 2015 diagnostic criteria for neuromyelitis optica spectrum disorders in a cohort of South Indian patients

Kanikannan, Meena A; Arepareddy, Praveen Kumar; Mathukumalli, Neeharika L; Yareeda, Sireesha; Kandadai, Rukmini Mridula; Jabeen, Afshan; Turaga, Suryaprabha; Borgohain, Rupam

doi:10.1016/j.msard.2019.07.024

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…Regardless of AQP4‐serostatus, acute myelitis was the predominant manifestation along the disease course, in 80% followed by optic neuritis in 74.4%. This was correlated with other studies reporting that the most common clinical core presentation along the disease course were acute myelitis ranging from 60% to 100% in populations with different racial backgrounds 43,45,48–50 …”

Section: Discussionsupporting

confidence: 88%

“…This was correlated with other studies reporting that the most common clinical core presentation along the disease course were acute myelitis ranging from 60% to 100% in populations with different racial backgrounds. 43,45,[48][49][50] Although patients' EDSS scores at the last follow up visit showed a wide variation ranging from 0 to 10 with a high mean score of 5.2 ± 2.6, no statistically significant differences could be found between the two groups. Similar scores were reported in studies from Africa, Latin America and Middle East.…”

Section: Discussionmentioning

confidence: 86%

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Radiological characteristics of neuromyelitis optica spectrum disorder in Egypt

Nasreldein

Farweez

El-Fetoh

et al. 2022

Clinical & Exp Neuroim

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Background Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune demyelinating disease of the central nervous system, which mainly affects the optic nerves and the spinal cord. Magnetic resonance imaging (MRI) plays an important role in the diagnosis of NMOSD based on the 2015 consensus criteria. Methods The objective of this study was to describe the MRI characteristics of NMOSD patients in Egypt. This were a prospective, observational study on patients fulfilling the 2015 diagnostic criteria of NMOSD. Patients were recruited consecutively from the Neurology, Psychiatry and Neurosurgery hospital, Assiut University Hospitals, Egypt from March 2019 until August 2020. Data on demographics, clinical and laboratory features were collected. MRI scan results were reviewed for each patient and compared according to Aquaporin4‐seropositivity. Results Ninety patients fulfilled NMOSD diagnostic criteria. The mean age at onset was 30.7±11.8 with a female predominance of 3:1. AQP4 antibodies were positive in 77/90 patients (85.6%). Seventy‐two patients (80%) had acute myelitis, 44 cases (61.1%) had longitudinally extensive transverse myelitis (LETM) and 61 cases (87.1%) had a central position in the cord. Bright spotty lesions (BSL) were found in 44 cases (61.1%). The most common site of cord involvement was the cervical region. Abnormal MRI brain scans were found in 81.1% of patients. No statistically significant differences could be found between the two groups. Conclusion There was a high frequency of abnormal spine and brain MRI findings in the Egyptian population. Even though no specific patterns were typical for AQP4‐specific serostatus, certain findings may suggest NMOSD diagnosis and warrant AQP4‐IgGs testing.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 86%

Radiological characteristics of neuromyelitis optica spectrum disorder in Egypt

Nasreldein

Farweez

El-Fetoh

et al. 2022

Clinical & Exp Neuroim

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“…Between 1999 and 2019, search results produced 99 articles related to “Neuromyelitis optica spectrum disorders”, “NMOSD”, “NMO”, “AQP4‐IgG”, “MOG‐IgG” AND India. After excluding reviews and case reports, 13 articles that described clinical, demographic features, investigations including testing for AQP4‐IgG and MOG‐IgG were included 39‐51 . These are listed chronologically in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…After excluding reviews and case reports, 13 articles that described clinical, demographic features, investigations including testing for AQP4-IgG and MOG-IgG were included. [39][40][41][42][43][44][45][46][47][48][49][50][51] These are listed chronologically in Table 2.…”

Section: Demographic and Clinical Features Of Nmosd In Indiamentioning

confidence: 99%

“…With the recent availability of commercial diagnostic kits (Euroimmun, Germany) for detection of AQP4-IgG & MOG-IgG, several papers have been published with definitive diagnosis of seropositive NMOSD from different parts of India. These included studies which described clinical features of AQP4-IgG-positive 39,40,45,46 and MOG-IgG-positive patients, 43,44,49,51 studies highlighting seroprevalence among patients with atypical demyelinating disorders 42 and comparative studies of demyelinating disorders from different regions of India. 48,50 Pediatric demyelinating disorders have been described from hospital settings.…”

Section: Demographic and Clinical Features Of Nmosd In Indiamentioning

confidence: 99%

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Epidemiology and clinical features of demyelinating disorders in India

Pandit

Mustafa

2021

Neurology & Clinical Neurosc

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In tropical countries like India, noncommunicable diseases have traditionally received less priority over infectious diseases. In recent times, however, demyelinating disorders of the central nervous system have become recognized as an important group of noncommunicable neurological disorders in India. It is possible that increasing awareness among doctors on one hand and availability of magnetic resonance imaging facilities (MRI) in teaching and private hospitals in the metropolitan cities of India on the other have contributed to early diagnosis and treatment.The study of demyelinating disorders of the nervous system in India has been limited by many factors. Kurtzke's 1 epidemiological studies pointed to India as having a low prevalence for multiple sclerosis (MS). Neuromyelitis optica (NMO) was considered a variant of MS. In the pre-MRI era, diagnosis of MS centered around clinical

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Neuromyelitis optica spectrum disorder and other central nervous system inflammatory diseases

Thakolwiboon,

Flanagan

2024

The Rose and Mackay Textbook of Autoimmune Diseases

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Validation of the 2015 diagnostic criteria for neuromyelitis optica spectrum disorders in a cohort of South Indian patients

Cited by 10 publications

References 20 publications

Radiological characteristics of neuromyelitis optica spectrum disorder in Egypt

Radiological characteristics of neuromyelitis optica spectrum disorder in Egypt

Epidemiology and clinical features of demyelinating disorders in India

Neuromyelitis optica spectrum disorder and other central nervous system inflammatory diseases

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