TQM and TPM are widely used performance improvement techniques employed by manufacturing organisations. They are employed world over for achieving customer satisfaction, reliability, productivity, market share, profitability and even survival. The study highlights the gain in business performance that can be obtained if TQM is supported by TPM in a manufacturing organisation. The study uses the confirmatory factor analysis (CFA) approach using structural equation modelling (SEM) in analysis of moment structures (AMOS 20.0) software to employ the inter-relationship among TQM and TPM variables. Using AMOS 20.0 software, TPM model and the transfusion of TQM-TPM model were constructed and the statistical data of the model fit values before and after modification indices were compared. Among the models, it was found that the SEM_TQM-TPM model fits the collected data better, which implies that the synergistic relationship of TQM and TPM paradigms can help Indian manufacturing industries to achieve good performances in terms of customer satisfaction, reliability, productivity, market share, profitability and even product quality, product cost and maintenance initiatives.