Validation of symptom measures in patients under investigation for postural orthostatic tachycardia syndrome (POTS): The Orthostatic Grading Scale (OGS) and the Symptom Screen for Small-fiber Polyneuropathy (SSS)

Knoop, Iris; Jones, Annie S.K.; Gall, Nicholas; Chilcot, Joseph; Pascoe, William; Moss-Morris, Rona

doi:10.1016/j.autneu.2023.103130

Autonomic Neuroscience

2023

DOI: 10.1016/j.autneu.2023.103130

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Validation of symptom measures in patients under investigation for postural orthostatic tachycardia syndrome (POTS): The Orthostatic Grading Scale (OGS) and the Symptom Screen for Small-fiber Polyneuropathy (SSS)

Iris Knoop,

Annie S.K. Jones,

Nicholas Gall

et al.

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2024

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Cited by 2 publications

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Randomized controlled trial of intravenous immunoglobulin for autoimmune postural orthostatic tachycardia syndrome (iSTAND)

Vernino,

Hopkins,

Bryarly

et al. 2024

Clin Auton Res

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Objective: Assess response to intravenous immunoglobulin (IVIG) in presumed autoimmune postural orthostatic tachycardia syndrome (POTS) Background: POTS predominantly affects young women and may be associated with systemic autoimmune disorders, serum autoantibodies or recent infection. Uncontrolled case studies suggest that IVIG is beneficial for treating autoimmune POTS. However, no previous randomized controlled trials have been conducted.Methods: This single site randomized controlled clinical trial compared IVIG to intravenous albumin infusions. Albumin comparator ensured blinding and control for effects of volume expansion. Eligible POTS patients had COMPASS-31 score ≥ 40 and met pre-determined criteria suggesting autoimmunity. Over 12 weeks, participants received 8 infusions (0.4gm/kg each). Four infusions were given weekly followed by four infusions every other week. Primary outcome measure was improvement in COMPASS-31 two weeks after final infusion.Results: 50 participants consented; 30 met inclusion criteria and received study drug (16 IVIG and 14 albumin; 29 female). Group baseline characteristics were well matched. 27 participants completed treatment protocol. Change in COMPASS-31 did not differ between groups (median change [IQR];

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Randomized controlled trial of intravenous immunoglobulin for autoimmune postural orthostatic tachycardia syndrome (iSTAND)

Vernino,

Hopkins,

Bryarly

et al. 2024

Clin Auton Res

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Aus dem Leben gerissen – Postakute Infektionssyndrome nach Covid-19

Hackl,

Hoffmann

2024

physiopraxis

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Mit den vielen Covid-19-Erkrankungen in den letzten Jahren steigen auch die Langzeitfolgen dieser Infektion. Dazu zählen unter anderem das posturale Tachykardiesyndrom, eine Dysfunktion des autonomen Nervensystems, und die Post-Exertional Malaise. Mit unzähligen kardiovaskulären und muskuloskelettalen, aber auch neurologischen Symptomen sind viele Patient*innen häufig nicht mehr in der Lage, ihren Alltag zu bestreiten.

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Validation of symptom measures in patients under investigation for postural orthostatic tachycardia syndrome (POTS): The Orthostatic Grading Scale (OGS) and the Symptom Screen for Small-fiber Polyneuropathy (SSS)

Cited by 2 publications

References 77 publications

Randomized controlled trial of intravenous immunoglobulin for autoimmune postural orthostatic tachycardia syndrome (iSTAND)

Randomized controlled trial of intravenous immunoglobulin for autoimmune postural orthostatic tachycardia syndrome (iSTAND)

Aus dem Leben gerissen – Postakute Infektionssyndrome nach Covid-19

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