Validation of Stevens-Johnson syndrome or toxic epidermal necrolysis diagnoses in the Clinical Practice Research Datalink

Abstract

Diagnoses of SJS/TEN are recorded with moderate diagnostic accuracy in the CPRD, which was substantially improved by additional expert review of all available information. We established a large population-based SJS/TEN study population of high diagnostic validity from the CPRD. Copyright © 2016 John Wiley & Sons, Ltd.

Incidence of and mortality from epidermal necrolysis (Stevens–Johnson syndrome/toxic epidermal necrolysis) in France during 2003–16: a four‐source capture–recapture estimate

“…A recent study performed in the U.S.A. using data from a large national electronic database found an overall annual incidence of SJS/TEN of 12·7 cases per million adults . However, patients were identified by using codes, and some misclassification (particularly false‐positive cases) was likely . Our estimation is much closer to the Frey et al .…”

“…12 However, patients were identified by using codes, and some misclassification (particularly false-positive cases) was likely. 23,24 Our estimation is much closer to the Frey et al estimation in the U.K. (i.e. 5Á76 cases per million inhabitants per year) in which incidence rates were adjusted on a previously calculated positive-predictive value for the codes used in order to minimize the bias of misclassification and a possible overestimation of incidence.…”

The risk of Stevens‐Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs

“…The positive predictive value (PPV) for SJS/TEN diagnoses in the CPRD was 0.87. The validation process is described in detail elsewhere . In short, two specialized clinicians classified all potential referred cases of SJS/TEN into probable/possible or unlikely cases according to prespecified criteria using available clinical details in the CPRD patient record.…”

“…The validation process is described in detail elsewhere. 12 In short, two specialized clinicians classified all potential referred cases of SJS/TEN into probable/possible or unlikely cases according to prespecified criteria using available clinical details in the CPRD patient record. We then compared our classification against a representative sample of patients for whom we had unequivocal diagnoses extracted from hospital discharge letters and hospital episode statistics data.…”

Antibiotic Drug Use and the Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Population-Based Case-Control Study

“…We conducted a population-based case-control study using data from the UK-based Clinical Practice Research Datalink (CPRD) (see Supplementary Table S1 online) to quantify the association between antibiotic use and SJS/ TEN (Herrett et al, 2015). The validated study population and detailed methods have been described in detail elsewhere (Frey et al, 2017a(Frey et al, , 2017b. In short, we identified 480 patients with a validated SJS/TEN diagnosis and a secondary care referral between 1995 and 2013 and matched four randomly chosen control individuals (!1 visit, practice visit recorded 30 days before or after the index date) to each patient based on age, sex, general practice, and years of recorded history in the CPRD before the index date.…”