Validation of SmartRank: A likelihood ratio software for searching national DNA databases with complex DNA profiles

Benschop, Corina C.G.; Merwe, Linda van de; Jong, Jeroen de; Vanvooren, Vanessa; Kempenaers, Morgane; Beek, C.P. van der; Barni, Filippo; Reyes, Eusebio López; Moulin, Léa; Pène, Laurent; Haned, Hinda; Sijen, Titia

doi:10.1016/j.fsigen.2017.04.008

Cited by 27 publications

(20 citation statements)

References 12 publications

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“…Therefore mixed profiles can mostly be used for direct comparison of profiles from known persons. A comparison with a national database, which is the aim of almost all investigations in cases where no suspect could be determined, is only possible for some selected national databases [4]. In general, for searching national databases, single person profiles are needed or at least preferable.…”

Section: Mixture Deconvolutionmentioning

confidence: 99%

Deconvolution of blood-blood mixtures using DEPArrayTM separated single cell STR profiling

2018

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Background. So far STR (Short Tandem Repeat) profiling of single cells has played hardly any role in forensic molecular-biological casework; however, the application of this technique could open up new possibilities for deducing the unambiguous DNA profile of each single contributor involved in a mixture of two or more components. Objective. For this purpose DEPArray TM technology was used to isolate single white blood cells from mixed stains containing blood from two or three different contributors. The STR profiling was carried out on each single cell. Material and methods. In order to standardize the interpretation of the findings, which, like all low template (LT) DNA analyses, shows characteristic artifacts, leukocytes from a fresh blood sample were examined in advance and

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Section: Mixture Deconvolutionmentioning

confidence: 99%

Deconvolution of blood-blood mixtures using DEPArrayTM separated single cell STR profiling

2018

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“…CSF1PO, FGA, TH01, TPOX, vWA, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51 and D21S11 markers belonged to the core CODIS loci used in the US, whereas D2S1338 and D19S433 belonged to the European core loci. We adopted a simulation strategy similar to the one used by Benschop et al to validate the Smartrank software [8].…”

Section: Complex Dna Profilesmentioning

confidence: 99%

“…The software CODIS, developed by the FBI, was reported to be used by more than half of them while other countries adopted their own developed technology to run their facilities [6,7]. In addition, open source solutions like SmartRank have also been released to mine national databases for contributors to complex DNA profiles [8].…”

Section: Introductionmentioning

confidence: 99%

GENis, an open-source multi-tier forensic DNA information system

Chernomoretz

Balparda²,

Grutta³

et al. 2020

Preprint

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GENis is an open source multi-tier information system developed to run a forensic DNA database at local, regional and national levels. 1 It was conceived as a highly customizable system, enforcing several security policies including: data encryption, double factor identification, structure of user's roles and permissions, system-wide secure log auditing, non-repudiation protocols and a blockchain-based option to reinforce genetic profile´s integrity. GENis is able to perform genetic profile queries of autosomal STR's and its design follows ENFSI 2 and ISFG 3 standards and recommendations. In this work, we present a summary of GENis architecture, the implemented matching rule definitions, and the Bayesian framework used to provide statistical significance of cold hits, that includes a new strategy to identify common contributors in mixture pairs.

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“…In recent years, likelihood ratio approaches based on probabilistic genotyping have been advocated for matching crime profiles to individuals [2][3][4][5]. The likelihood ratio (LR) is generally accepted as the most powerful and relevant statistic that gives the weight of the DNA evidence [3] (which can be on a log10 scale).…”

Section: Introductionmentioning

confidence: 99%

The efficacy of DNA mixture to mixture matching

Bright

Taylor

Kerr

et al. 2019

Forensic Science International: Genetics

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Highlights  We investigate a method to identify a common contributor in two mixed DNA profiles  The discrimination power is limited by the smallest DNA contribution to the profiles  We show good ability to find pairs of profiles with a common contributor  This tool gives the ability to provide intelligence information

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Validation of SmartRank: A likelihood ratio software for searching national DNA databases with complex DNA profiles

Cited by 27 publications

References 12 publications

Deconvolution of blood-blood mixtures using DEPArrayTM separated single cell STR profiling

Deconvolution of blood-blood mixtures using DEPArrayTM separated single cell STR profiling

GENis, an open-source multi-tier forensic DNA information system

The efficacy of DNA mixture to mixture matching

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