Validation of Prosthetic Mitral Regurgitation Quantification Using Novel Angiographic Platform by Mock Circulation

Kawashima, Hideyuki; Serruys, Patrick W.; Modolo, Rodrigo; Pighi, Michele; Wang, Rutao; Ono, Masafumi; Aben, Jean‐Paul; Chang, Chun Chin; Hauwermeiren, Hadewych Van; Brunnett, Bill; Cox, Martijn; Rosseel, Liesbeth; Mylotte, Darren; Flameng, Willem; Onuma, Yoshinobu; Soliman, Osama Ibrahim Ibrahim

doi:10.1016/j.jcin.2021.04.046

Cited by 3 publications

(5 citation statements)

References 18 publications

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“…The most common objection raised by clinicians regarding the methodology of video-densitometry is the potential for measurement errors due to an assumed parallax effect when the outflow tract is assessed from various angiographic views. However, the approach is aimed at circumventing this issue; a video-densitometric measurement is the constant product of an area in which the radiopaque contrast is detected, multiplied by the density (hemodilution) of the radiopaque contrast medium in that area/volume ( 6 ). This means that the x-ray attenuation of an object is virtually unaffected by the viewing direction (angulation) of the x-ray system.…”

Section: The Concept Of Video-densitometry and Phantom Validationmentioning

confidence: 99%

“… Video-densitometric assessment of an egg-shaped plastic phantom filled with radiopaque contrast medium rotated in an x-ray field from short (0, 180 degree) to long axis view (90 degree). [Modified From Kawashima, et al ( 6 )]. …”

Section: The Concept Of Video-densitometry and Phantom Validationmentioning

confidence: 99%

“…Recently an attempt was made to adapt the video-densitometric methodology to the mitral space. In vitro MRF and MRV were assessed in a mock circulation with transonic flow measurement at a cardiac output comparable as the one measured in vivo by thermodilution Supplementary Figure S13C ( 6 ).…”

Section: Future Developmentsmentioning

confidence: 99%

“…It was concluded that in vivo MRF using the novel software is feasible, accurate, and highly reproducible. These promising results have led us to initiate the first human feasibility study comprising patients undergoing percutaneous mitral valve edge-to-edge repair ( 6 ) or mitral valve replacement Figure 11 .…”

Section: Future Developmentsmentioning

confidence: 99%

See 3 more Smart Citations

Quantitative aortography for assessment of aortic regurgitation in the era of percutaneous aortic valve replacement

Abdelshafy,

Serruys,

Tsai

et al. 2023

Front. Cardiovasc. Med.

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Paravalvular leak (PVL) is a shortcoming that can erode the clinical benefits of transcatheter valve replacement (TAVR) and therefore a readily applicable method (aortography) to quantitate PVL objectively and accurately in the interventional suite is appealing to all operators. The ratio between the areas of the time-density curves in the aorta and left ventricular outflow tract (LVOT-AR) defines the regurgitation fraction (RF). This technique has been validated in a mock circulation; a single injection in diastole was further tested in porcine and ovine models. In the clinical setting, LVOT-AR was compared with trans-thoracic and trans-oesophageal echocardiography and cardiac magnetic resonance imaging. LVOT-AR > 17% discriminates mild from moderate aortic regurgitation on echocardiography and confers a poor prognosis in multiple registries, and justifies balloon post-dilatation. The LVOT-AR differentiates the individual performances of many old and novel devices and is being used in ongoing randomized trials and registries.

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Section: The Concept Of Video-densitometry and Phantom Validationmentioning

confidence: 99%

Section: The Concept Of Video-densitometry and Phantom Validationmentioning

confidence: 99%

Section: Future Developmentsmentioning

confidence: 99%

Section: Future Developmentsmentioning

confidence: 99%

See 2 more Smart Citations

Quantitative aortography for assessment of aortic regurgitation in the era of percutaneous aortic valve replacement

Abdelshafy,

Serruys,

Tsai

et al. 2023

Front. Cardiovasc. Med.

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“…Quantitative assessment of aortic regurgitation (AR) using videodensitometric aortography is a well-documented technique 1 , but the angiographic assessment of mitral regurgitation (MR) is still semiquantitative and operator dependent. The feasibility and accuracy of this novel technology has been investigated and validated in animals 2 , and the first application in a patient, post-percutaneous mitral replacement, has been reported.…”

Section: Quantitative Videodensitometric Assessment Of Residual Mitra...mentioning

confidence: 99%

Quantitative videodensitometric assessment of residual mitral regurgitation after transcatheter mitral valve replacement: a first-in-human report from China

Elzomor¹,

Chen²,

Chen³

et al. 2022

AsiaIntervention

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Left Ventricular Angiography for Mitral Regurgitation Assessment

Enríquez-Sarano

2021

JACC: Cardiovascular Interventions

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Validation of Prosthetic Mitral Regurgitation Quantification Using Novel Angiographic Platform by Mock Circulation

Cited by 3 publications

References 18 publications

Quantitative aortography for assessment of aortic regurgitation in the era of percutaneous aortic valve replacement

Quantitative aortography for assessment of aortic regurgitation in the era of percutaneous aortic valve replacement

Quantitative videodensitometric assessment of residual mitral regurgitation after transcatheter mitral valve replacement: a first-in-human report from China

Left Ventricular Angiography for Mitral Regurgitation Assessment

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