Validation of “prodromal” criteria to detect individuals at ultra high risk of psychosis: 2 year follow-up

Yung, Alison R.; Nelson, Barnaby; Stanford, Carrie; Simmons, Magenta; Cosgrave, Elizabeth; Killackey, Eóin; Phillips, Lisa; Bechdolf, Andreas; Buckby, Joe; McGorry, Patrick D.

doi:10.1016/j.schres.2008.07.012

Cited by 324 publications

(306 citation statements)

References 20 publications

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“…The underlying substrate for such a 'swelling' prior to the actual conversion to psychosis could be an increased apoptotic activity involving a transient controlled inflammatory response while removing apoptotic cells, or cell parts (axons and dendrites) (Berger et al, 2003;Lieberman et al, 2007). If true, this may imply that new benign neuroprotective treatment strategies may be especially effective in this late phase of prodrome and be able to modulate underlying neurobiological processes and potentially delay or even prevent the onset of psychosis Our study may not be fully comparable to other structural MRI studies because different research groups have used slightly different ways of defining their high risk (Fusar-Poli P et al, 2008;Yung et al, 2008) and first episode psychosis (McGorry et al, 2004;Schimmelmann et al 2005) cohorts, used different ascertainment strategies, different anatomic boundaries of the hippocampus (with or without amygdala) as well as applied different techniques to measure HV (i.e. manual vs. automated methods).…”

Section: Arms-nt)mentioning

confidence: 89%

Hippocampus abnormalities in at risk mental states for psychosis? A cross-sectional high resolution region of interest magnetic resonance imaging study

Buehlmann

Berger²,

Aston

et al. 2010

Journal of Psychiatric Research

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Abstract:Background: Hippocampal volume (HV) reduction is well documented in schizophrenia.However, it is still unclear whether this change is a pre-existing vulnerability factor, a sign of disease progression, a consequence of environmental factors, such as drug use, antipsychotic medication, or malnutrition. The timing of HV changes is not well established, but a lack of macrostructural hippocampal brain abnormalities before disease onset would rather support a neuroprogressive illness model. Results: The overall ANCOVA model comparing left HVs across FEP, ARMS and HC indicated a significant general group effect (p < .05) with largest volumes in ARMS and smallest in FEP. ARMS-T subjects had significantly larger left HVs compared to FE but no HV differences compared to HC (p<0.05). Over all groups, we found an asymmetry between the left and right mean HVs and a strong effect of sex.

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Section: Arms-nt)mentioning

confidence: 89%

Hippocampus abnormalities in at risk mental states for psychosis? A cross-sectional high resolution region of interest magnetic resonance imaging study

Buehlmann

Berger²,

Aston

et al. 2010

Journal of Psychiatric Research

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“…Additionally, around 10% of ARMS individuals have attempted suicide shortly before presentation [32]. In terms of transition rates to psychosis a recent meta-analysis (mean age 19.9 years) estimated around 18% of such individuals develop psychosis by six months, reaching 36% after three years [33] with existing data suggesting transition is most likely within the first six months after identification [34].…”

Section: Introductionmentioning

confidence: 99%

The ‘At-Risk Mental State’ for Psychosis in Adolescents: Clinical Presentation, Transition and Remission

Welsh

Tiffin

2013

Child Psychiatry Hum Dev

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. (2014) 'The 'At-risk mental state' for psychosis in adolescents : clinical presentation, transition and remission.', Child psychiatry and human development., 45 (1). pp. 90-98.Further information on publisher's website:http://dx.doi.org/10.1007/s10578-013-0380-z Publisher's copyright statement:The nal publication is available at Springer via http://dx.doi.org/10.1007/s10578-013-0380-z.Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. 2 Abstract:Despite increased efforts over the last decade to prospectively identify individuals at ultrahigh risk of developing a psychotic illness, limited attention has been specifically directed towards adolescent populations (<18 years). In order to evaluate how those under 18 fulfilling the operationalised criteria for an At-Risk Mental State (ARMS) present and fare over time, we conducted an observational study. Participants (N=30) generally reported a high degree of functional disability and frequent and distressing perceptual disturbance, mainly in the form of auditory hallucinations. Seventy percent (21/30) were found to fulfil the criteria for a co-morbid ICD-10 listed mental health disorder, with mood (affective; 13/30) disorders being most prevalent. Overall transition rates to psychosis were low at 24 month follow-up (2/28; 7.1%) whilst many participants demonstrated a significant reduction in psychotic-like symptoms. The generalisation of these findings may be limited due to the small sample size and require replication in a larger sample.

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“…Individuals with an "at-risk mental state" (ARMS) present with prodromal symptoms of psychosis and have a very high risk for the disease developing within the next 2 years. 10 The ARMS is characterized by poor psycho social functioning 11 and neurocognitive impairments. 12 Interestingly, 3 recent independent studies of individuals at enhanced risk for psychosis have confirmed that P300 ab normalities are already evident in the prepsychotic phases.…”

Section: Introductionmentioning

confidence: 99%

White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI–EEG study

Fusar‐Poli

Crossley

Woolley

et al. 2011

jpn

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Validation of “prodromal” criteria to detect individuals at ultra high risk of psychosis: 2 year follow-up

Cited by 324 publications

References 20 publications

Hippocampus abnormalities in at risk mental states for psychosis? A cross-sectional high resolution region of interest magnetic resonance imaging study

Hippocampus abnormalities in at risk mental states for psychosis? A cross-sectional high resolution region of interest magnetic resonance imaging study

The ‘At-Risk Mental State’ for Psychosis in Adolescents: Clinical Presentation, Transition and Remission

White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI–EEG study

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