Validation of predictive models for disease outcomes in paediatric ulcerative colitis: A multicentre prospective inception cohort

Abstract

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Editorial: Predicting paediatric ulcerative colitis outcomes—how can we improve?

“…Baseline risk factors that have been identified as predictors of poor 1‐year disease outcome in paediatric ulcerative colitis (UC) are severe endoscopic activity, hypoalbuminemia, anaemia, elevated faecal calprotectin and an elevated paediatric UC activity index (PUCAI) 2–5 . This current prospective study explored these baseline predictors in 223 paediatric patients with newly diagnosed UC from two study cohorts 6 . The authors included 17 centres from Europe, the Middle East and Southeast Asia.…”

“…[2][3][4][5] This current prospective study explored these baseline predictors in 223 paediatric patients with newly diagnosed UC from two study cohorts. 6 The authors included 17 centres from Europe, the Middle East and Southeast Asia. Their main outcomes were steroid-free clinical remission (SFR) at 3 and 12 months, and sus-tainedSFRat1 year.Theyalsoanalysedpredictorsofescalationto biologic therapy, colectomy, and rate of acute severe colitis (ASC).All patients had induction therapy with 5-ASA or steroids; a quarter escalated to biologic therapy within the first year.…”