2015
DOI: 10.3390/ijms161125976
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Validation of PDE9A Gene Identified in GWAS Showing Strong Association with Milk Production Traits in Chinese Holstein

Abstract: Phosphodiesterase9A (PDE9A) is a cyclic guanosine monophosphate (cGMP)-specific enzyme widely expressed among the tissues, which is important in activating cGMP-dependent signaling pathways. In our previous genome-wide association study, a single nucleotide polymorphism (SNP) (BTA-55340-no-rsb) located in the intron 14 of PDE9A, was found to be significantly associated with protein yield. In addition, we found that PDE9A was highly expressed in mammary gland by analyzing its mRNA expression in different tissue… Show more

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Cited by 19 publications
(12 citation statements)
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“…Previously, SLC37A1 was associated with MY, FP, and PP (Kemper et al, 2016;Raven et al, 2016;Pausch et al, 2017), supporting our results for MY, and with other milk components such as α S1 -CN and α-LA (Sanchez et al, 2017), phosphorus concentration , and FA composition (Olsen et al, 2017). The PDE9A gene is a cGMP-specific phosphodiesterase also highly expressed in mammary gland and previously associated with milk production traits (Yang et al, 2015).…”
Section: Resultssupporting
confidence: 88%
“…Previously, SLC37A1 was associated with MY, FP, and PP (Kemper et al, 2016;Raven et al, 2016;Pausch et al, 2017), supporting our results for MY, and with other milk components such as α S1 -CN and α-LA (Sanchez et al, 2017), phosphorus concentration , and FA composition (Olsen et al, 2017). The PDE9A gene is a cGMP-specific phosphodiesterase also highly expressed in mammary gland and previously associated with milk production traits (Yang et al, 2015).…”
Section: Resultssupporting
confidence: 88%
“…This top cluster is directly involved in mammary gland development, regulation of response to a stimulus, gland development, epithelium development, tissue development, animal organ development, system development and multicellular organism development. This was partly in agreement to works reported by Yang et al [ 43 ] on QTL associated with follicle stimulating hormone production in Chinese Holstein cattle.…”
Section: Discussionsupporting
confidence: 93%
“…A QTL for percentage protein was found at the orthologous bovine position of our QTL on the CHI 1 in Chinese Holstein cows 49 . Later, 11 more SNPs were identified on the phosphodiesterase 9A ( PDE9A ) gene, located in the QTL confidence interval, associated with the different milk production traits 50 . This gene is involved in the activation of the cGMP dependent pathway and is therefore a strong candidate for our QTL for PC on CHI1.…”
Section: Discussionmentioning
confidence: 99%