Validation of near infrared spectroscopy to measure abdominal somatic tissue oxygen saturation in neonates

Said, Mariam; Niforatos, Nickie; Rais-Bahrami, Khodayar

doi:10.3233/npm-1365112

Cited by 21 publications

(12 citation statements)

References 14 publications

(23 reference statements)

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“…They demonstrated a strong correlation between abdominal rSO 2 and systemic mixed venous saturation (r=0.89, p<0.0001), gastric pH (r=0.79, p<0.0001) and serum lactate (r=0.77, p<0.0001). Said et al 14 showed correlation between abdominal NIRS and umbilical venous catheter oxygen saturations. Fortune et al 2 used abdominal NIRS (hypogastrium) to determine splanchnic perfusion in comparison to cerebral perfusion.…”

Section: Resultsmentioning

confidence: 99%

Measurement of gut oxygenation in the neonatal population using near-infrared spectroscopy: a clinical tool?

Seager

Longley

Aladangady

et al. 2019

Arch Dis Child Fetal Neonatal Ed

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ContextNear-infrared spectroscopy (NIRS) is a non-invasive bedside monitor of tissue oxygenation that may be a useful clinical tool in monitoring of gut oxygenation in newborn infants.ObjectiveTo systematically review literature to determine whether NIRS is a reliable tool to monitor gut oxygenation on neonatal units.Data sourcesPubMed and Embase databases were searched using the terms ‘neonate’, ‘preterm infants’, ‘NIRS’ and ‘gut oxygenation’ (2001–2018).Study selectionStudies were included if they met inclusion criteria (clinical trial, observational studies, neonatal population, articles in English and reviewing regional gut oxygen saturations) and exclusion criteria (not evaluating abdominal NIRS or regional oxygen saturations).Data extractionTwo authors independently searched PubMed and Embase using the predefined terms, appraised study quality and extracted from 30 studies the study design and outcome data.LimitationsPotential for publication bias, majority of studies were prospective cohort studies and small sample sizes.ResultsThirty studies were reviewed assessing the validity of abdominal NIRS and potential application in neonates. Studies reviewed assessed abdominal NIRS in different settings including normal neonates, bolus and continuous feeding, during feed intolerance, necrotising enterocolitis and transfusion with packed red cells. Several observational studies demonstrated how NIRS could be used in clinical practice.ConclusionsNIRS may prove to be a useful bedside tool on the neonatal unit, working alongside current clinical tools in the monitoring of newborn infants (preterm and term) and inform clinical management. We recommend further studies including randomised controlled trials looking at specific measurements and cut-offs for abdominal NIRS for use in further clinical practice.

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Section: Resultsmentioning

confidence: 99%

Measurement of gut oxygenation in the neonatal population using near-infrared spectroscopy: a clinical tool?

Seager

Longley

Aladangady

et al. 2019

Arch Dis Child Fetal Neonatal Ed

View full text Add to dashboard Cite

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“…Despite this, there are a plethora of publications doing just this. [11][12][13][14] Furthermore, the algorithm of a monitoring device may include features that compensate for certain factors during normal conditions. However, this does not necessarily mean that it will work under more extreme or pathologic circumstances (where you really want the monitor to work properly, eg, low cardiac output states or intestinal ischemia).…”

Section: Furthermore We Do Not Know What the Reference/target Valuesmentioning

confidence: 99%

A healthy measure of monitoring fundamentals!

Wallin

Lönnqvist

2018

Pediatric Anesthesia

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Summary Monitoring represents a seminal part of modern anesthesia but it is imperative that clinicians and health care staff understand the fundamentals of measurements to correctly understand, apply, and at times discard various monitoring options. The world of measurements is a very precise science that needs to be fully acknowledged. This communication aims at highlighting certain issues relevant to everyday clinical monitoring.

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“…It allows for detection of heart rate, respiratory rate, and arterial oxygen saturation. Near-infrared spectroscopy (NIRS) allows for specific tissue oxygen saturation (StO 2 ) measurement continuously and non-invasively by measuring chromophores in the body such as hemoglobin, myoglobin, and cytochrome aa3 ( 2 – 4 ). It reflects tissue oxygen supply and demand regionally allowing one to calculate fractional tissue oxygen extraction (FTOE) and cerebro-splanchnic oxygenation ratio (CSOR) ( 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

“…There are many different NIRS methodologies to assess this measurement as reviewed by Kooi et al ( 8 ). Trending cerebral and/or somatic NIRS under various clinical circumstances has also been well studied ( 2 , 9 – 13 ). However, the comparison of cerebral and somatic NIRS parameters with measured vital signs in critically ill infants in the NICU has not been well studied.…”

Section: Introductionmentioning

confidence: 99%

Significant Correlation between Regional Tissue Oxygen Saturation and Vital Signs of Critically Ill Infants

et al. 2017

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BackgroundNear-infrared spectroscopy (NIRS) has been used to non-invasively measure specific tissue oxygen saturation (StO2) continuously. Cerebral autoregulation status can be derived from NIRS and arterial blood pressure. The relationship of both cerebral and somatic StO2, fractional tissue oxygen extraction (FTOE), and cerebro-splanchnic oxygenation ratio (CSOR) with measured vital sign parameters for Neonatal Intensive Care Unit (NICU) patients has not been well studied.ObjectiveThe aims of this study are to determine if significant relationships of brain and somatic StO2, brain and somatic FTOE, and CSOR parameters with vital signs for neonates exist and assess relationship between pressure passivity index, cerebral autoregulation, and mean blood pressure (MBP).Design/methodsNeonates weighing < 5 kg, preferentially with an arterial catheter, were enrolled in the study. FORE-SIGHT Elite (CASMedical Systems, Inc., Branford, CT, USA) cerebral and somatic NIRS sensors were placed over the abdominal right upper quadrant and right frontal-temporal area of the forehead for 24 h. Vital signs including arterial MBP were recorded simultaneously from the patients’ bedside monitor. Data were averaged into 60 s windows and analyzed using linear regression. Results were stratified by gestational age (GA), birth weight (BW), and presence of brain abnormality.ResultsData were obtained from 27 subjects (GA 22.2–42 weeks). Two subjects did not have an arterial line, thus they were not included in the MBP measurements. There were ~28,000–31,000 paired data points per comparison. Significant positive and negative correlations (p value < 0.0001) were noted between NIRS parameters and vital signs. When stratified by BW, there was a positive correlation between brain StO2 (StO2B) and MBP in the <1,500 g BW group (r = 0.193) and a negative correlation in >1,500 g group (r = 0.057). Brain and somatic FTOE in <1,500 g BW revealed a negative correlation with MBP (r = 0.172 and r = 0.086, respectively). In patients with an abnormal brain scan, a positive correlation was noted between StO2B and MBP (r = 0.354), and a negative correlation was noted between FTOE-B and MBP (r = 0.305). Generated pressure passive index plots suggested good cerebral autoregulation at low normal MBP ranges for lower weight and GA subjects.ConclusionThere is a significant correlation between cerebral and somatic StO2 and FTOE with measured vital sign parameters in NICU patients.

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Validation of near infrared spectroscopy to measure abdominal somatic tissue oxygen saturation in neonates

Cited by 21 publications

References 14 publications

Measurement of gut oxygenation in the neonatal population using near-infrared spectroscopy: a clinical tool?

Measurement of gut oxygenation in the neonatal population using near-infrared spectroscopy: a clinical tool?

A healthy measure of monitoring fundamentals!

Significant Correlation between Regional Tissue Oxygen Saturation and Vital Signs of Critically Ill Infants

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