Validation of multicolor imaging signatures of central serous chorioretinopathy lesions vis-a-vis conventional color fundus photographs

Abstract

Purpose: The current study compares the ability of multicolor imaging (MCI) to detect the lesions of central serous chorioretinopathy against conventional color fundus photographs (CFP). Methods: It was a retrospective, observational case series of 93 eyes of 58 patients of central serous chorioretinopathy who underwent MCI and CFP. MCI and spectral-domain optical coherence tomography (SD-OCT) were performed using Spectralis SD-OCT system (HRA + OCT). CFP was obtained using FF 450 Plus fundus camera (Carl Zeiss Meditec, Jena, Germany). SD-OCT was considered gold standard for subretinal fluid (SRF) and retinal pigment epithelium detachment (PED). CFP was considered confirmatory investigation for fibrin and blue autofluorescence image (BAF) was considered gold standard to detect retinal pigment epithelium (RPE) atrophy. Results: CFP could detect SRF in 41 (44.1%) eyes. MCI detected SRF in 43 (46.2%) eyes. The sensitivity and specificity of MCI to detect SRF were 70.7% and 94.3%, respectively. PED was detected by CFP in 21 (22.6%) eyes and MCI in 27 (29%) eyes. The sensitivity and specificity of MCI to detect PED were 70% and 97.7% respectively. CFP could pick RPE atrophy in 52 (55.9%) eyes whereas MCI was picked it in 78 (83.9%) of eyes. Conclusion: Both MCI and CFP were inferior to a gold standard in identifying the SRF, PED, and RPE atrophy. However, MCI was better than CFP in comparison with gold standard for these clinical findings in CSC. Thus, MCI seems to be a more valuable imaging tool compared to CFP.

Clinical application of multicolor scanning laser ophthalmology in diagnosis and grading of central retinal artery occlusion

“…MC image compiles the three reflectances into a pseudocolor image (Tan et al, 2016 ). Nowadays, several studies have identified the obvious value of MC images in posterior segment pathology diseases, such as central serous chorioretinopathy (CSC; He et al, 2020 ; Saurabh et al, 2020 ), epiretinal membranes (ERM; Song et al, 2019 ; Terasaki et al, 2020 ), diabetic retinopathy (DR; Roy et al, 2019 ; Arrigo et al, 2021 ), and age-related macular degeneration (AMD; Graham et al, 2018 ; De Rosa et al, 2020 ). On MC and GR images rather than CFPs, hard exudates, cotton-wool spots, retinal microaneurysms, and hemorrhages were better identified (Roy et al, 2019 ; Arrigo et al, 2021 ).…”

Comparison of Color Fundus Photography and Multicolor Fundus Imaging for Detection of Lesions in Diabetic Retinopathy and Retinal Vein Occlusion

“…Tan et al 21 compared the two image modalities in patients with polypoidal choroidal vasculopathy, concluding that, despite differences in the appearance, they are comparable in the detection of multiple features of the disease. Saurabh et al 22 compared the ability of MFI to detect a typical lesion of central serous chorioretinopathy against CFP, concluding that MFI had higher sensitivity and lower specificity for retinal pigment epithelium atrophy, that serous pigment epithelium detachment was more easily detected on MFI, and that both image modalities were similar in their ability to detect subretinal fluid. Regarding the presence of fibrin, it was seen more distinctly on CFP.…”

MultiColor imaging in urticarial vasculitis with recurrent branch retinal artery occlusion in a case with positive toxoplasma IgG and interferon-gamma release assay - Case report

“…High-resolution, detailed MCI can highlight structures and pathologies not visible on ophthalmoscopy and color fundus photographs (CFP) in lesions of epiretinal membrane, 12 , 13 diabetic macular edema, 14 and central serous chorioretinopathy. 15 …”