Validation of kinetic modeling of progesterone release from polymeric membranes

Development and In Vitro Evaluation of Solid Dispersions As Strategy to Improve Albendazole Biopharmaceutical Behavior

“…The experimental data of the cumulative amount of dissolved ABZ profiles were well correlated by a model previously developed and validated by our research group [39,40]. Where M% is the percentage of drug dissolved at time t, and parameters a and b are given in (% min -1 ) and (min -1 ), respectively.…”

“…Interestingly, the value of the parameter a is the IDR [40], since the dissolution rate at any time is given by:…”

“…This simple model can lump together both diffusional and polymer relaxation steps present in this process, and it is represented by Equation 2[40]:…”

Films based on the biopolymer poly(3-hydroxybutyrate) as platforms for the controlled release of dexamethasone

“…The proposed and validated mathematical model used (Fernández-Colino et al, 2016, Romero et al, 2017) follows a lumped second-order kinetics. It describes satisfactorily processes where diffusion and transfer phenomena are present, or when there is only an external transfer into a fluid medium where the drug concentration increases steadily.…”

“…The purpose of this research was to design and characterize DX loaded PHB films, and to evaluate the DX release from these matrices. Kinetic and transport phenomena involved in the release of the drug were considered by the “lumped model” developed and validated by our research group (Fernández-Colino et al, 2016, Romero et al, 2016, Romero et al, 2017). Pharmaceutic parameters were calculated and the influence of different DX loads on the release profiles was evaluated through similarity and difference factors.…”