Validation of Highly Accelerated Wave–CAIPI SWI Compared with Conventional SWI and T2*-Weighted Gradient Recalled-Echo for Routine Clinical Brain MRI at 3T

Conklin, John; Longo, Maria Gabriela Figueiró; Cauley, Stephen F.; Setsompop, Kawin; González, R Gilberto; Schaefer, Pamela W.; Kirsch, John E.; Rapalino, Otto; Huang, Susie Y.

doi:10.3174/ajnr.a6295

Cited by 38 publications

(51 citation statements)

References 24 publications

(28 reference statements)

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“…All patients underwent brain imaging on a 3 Tesla Skyra MRI scanner (Siemens Healthcare) using an ultrafast 3D SWI sequence [ 15 ] with the following parameters: TE/TR = 21.5/40 ms, voxel dimensions = 0.9 × 0.9 × 1.8 mm 3 , Wave-CAIPI acceleration R = 6, total scan time 100 s. Conventional T1, T2, fluid-attenuated inversion recovery (FLAIR), and diffusion-weighted images (DWI) were also obtained. Two board-certified neuroradiologists (J.C., S.Y.H.)…”

Section: Methodsmentioning

confidence: 99%

“…We investigated the imaging characteristics of COVID-19 brain injury by performing ultrafast high-resolution susceptibility-weighted imaging (SWI) MRI [ 15 ] on a clinical MRI scanner located in our Neurosciences Intensive Care Unit (ICU). We focused on SWI because emerging evidence suggests that COVID-19 patients are at risk for microvascular lesions [ [8] , [9] , [10] , 16 ], and the SWI sequence provides optimal sensitivity for detecting microvascular lesions based upon their paramagnetic susceptibility effects in an MRI scanner's magnetic field [ 15 ]. In a cohort of 16 consecutively imaged critically ill patients with COVID-19, we tested the hypothesis that COVID-19 is associated with cerebral microvascular injury detectable by SWI.…”

Section: Introductionmentioning

confidence: 99%

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Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19

Conklin

Frosch

Mukerji

et al. 2021

Journal of the Neurological Sciences

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We evaluated the incidence, distribution, and histopathologic correlates of microvascular brain lesions in patients with severe COVID-19. Sixteen consecutive patients admitted to the intensive care unit with severe COVID-19 undergoing brain MRI for evaluation of coma or neurologic deficits were retrospectively identified. Eleven patients had punctate susceptibility-weighted imaging (SWI) lesions in the subcortical and deep white matter, eight patients had >10 SWI lesions, and four patients had lesions involving the corpus callosum. The distribution of SWI lesions was similar to that seen in patients with hypoxic respiratory failure, sepsis, and disseminated intravascular coagulation. Brain autopsy in one patient revealed that SWI lesions corresponded to widespread microvascular injury, characterized by perivascular and parenchymal petechial hemorrhages and microscopic ischemic lesions. Collectively, these radiologic and histopathologic findings add to growing evidence that patients with severe COVID-19 are at risk for multifocal microvascular hemorrhagic and ischemic lesions in the subcortical and deep white matter.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19

Conklin

Frosch

Mukerji

et al. 2021

Journal of the Neurological Sciences

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“…Parallel imaging works by acquiring a reduced amount of k -space data with an array of receiver coils. Research is underway to see if it can provide equivalent information to the current gold-standard MRI [ 68 , 69 ]. Positron emission tomography 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) is a nuclear imaging modality that identifies increased glucose uptake in tissues.…”

Section: Discussionmentioning

confidence: 99%

Section: Imaging Diagnosticsmentioning

confidence: 99%

A systematic review of ongoing clinical trials in optic pathway gliomas

et al. 2020

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Introduction Optic pathway gliomas (OPGs), also known as Visual Pathway Gliomas, are insidious, debilitating tumours. They are most commonly WHO grade 1 pilocytic astrocytomas and frequently occur in patients with neurofibromatosis type 1. The location of OPGs within the optic pathway typically precludes complete resection or optimal radiation dosing, hence outcomes remain poor compared to many other low-grade gliomas. The aim of this systematic review was to formulate a comprehensive list of all current ongoing clinical trials that are specifically looking at clinical care of OPGs in order to identify trends in current research and provide an overview to guide future research efforts. Methods This systematic review was conducted in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The Cochrane Controlled Register of Trials (CENTRAL) and ClinicalTrials.gov were searched. Inclusion and exclusion criteria were applied and final results were reviewed. Results 501 clinical trials were identified with the search strategy. All were screened and eligible studies extracted and reviewed. This yielded 36 ongoing clinical trials, 27 of which were pharmacological agents in phase I-III. The remaining trials were a mixture of biological agents, radiation optimisation, diagnostic imaging, surgical intervention, and a social function analysis. Conclusion OPG is a complex multifaceted disease, and advances in care require ongoing research efforts across a spectrum of different research fields. This review provides an update on the current state of research in OPG and summarises ongoing trials.

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“…9,10 The adoption of Wave-CAIPI technology for highly accelerated imaging in clinical and research studies will be facilitated by systematic validation of its use in routine clinical imaging protocols. 11 Wave-CAIPI has been optimized for whole-brain imaging with MPRAGE in healthy volunteers 12 and has demonstrated potential in accelerating whole-brain volumetric evaluation of healthy volunteers 13 but has not yet been systematically evaluated in a clinical setting.…”

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confidence: 99%

Evaluation of Ultrafast Wave-CAIPI MPRAGE for Visual Grading and Automated Measurement of Brain Tissue Volume

Longo¹,

Conklin

Cauley

et al. 2020

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Volumetric brain MR imaging typically has long acquisition times. We sought to evaluate an ultrafast MPRAGE sequence based on Wave-CAIPI (Wave-MPRAGE) compared with standard MPRAGE for evaluation of regional brain tissue volumes. MATERIALS AND METHODS: We performed scan-rescan experiments in 10 healthy volunteers to evaluate the intraindividual variability of the brain volumes measured using the standard and Wave-MPRAGE sequences. We then evaluated 43 consecutive patients undergoing brain MR imaging. Patients underwent 3T brain MR imaging, including a standard MPRAGE sequence (acceleration factor [R] ¼ 2, acquisition time [TA] ¼ 5.2 minutes) and an ultrafast Wave-MPRAGE sequence (R ¼ 9, TA ¼ 1.15 minutes for the 32-channel coil; R ¼ 6, TA ¼ 1.75 minutes for the 20-channel coil). Automated segmentation of regional brain volume was performed. Two radiologists evaluated regional brain atrophy using semiquantitative visual rating scales. RESULTS: The mean absolute symmetrized percent change in the healthy volunteers participating in the scan-rescan experiments was not statistically different in any brain region for both the standard and Wave-MPRAGE sequences. In the patients undergoing evaluation for neurodegenerative disease, the Dice coefficient of similarity between volumetric measurements obtained from standard and Wave-MPRAGE ranged from 0.86 to 0.95. Similarly, for all regions, the absolute symmetrized percent change for brain volume and cortical thickness showed ,6% difference between the 2 sequences. In the semiquantitative visual comparison, the differences between the 2 radiologists' scores were not clinically or statistically significant. CONCLUSIONS: Brain volumes estimated using ultrafast Wave-MPRAGE show low intraindividual variability and are comparable with those estimated using standard MPRAGE in patients undergoing clinical evaluation for suspected neurodegenerative disease. ABBREVIATIONS: ASPC ¼ absolute symmetrized percent change; VBM ¼ voxel-based morphometry V olumetric brain MR imaging is widely used in clinical and research settings for the evaluation of patients with suspected neurodegenerative disease. Regional patterns of tissue loss aid in generating a differential diagnosis and assessing prognosis, and the identification of regional volume loss is increasingly used as an outcome measure in trials of potentially disease-modifying therapies. 1-4 Of particular value, the T1-weighted MPRAGE sequence provides excellent spatial resolution and tissue contrast 5 but has long acquisition times due to the need to encode a large number of k-space lines and the added TI required to achieve the prepared T1-weighted contrast. Unfortunately, long

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Validation of Highly Accelerated Wave–CAIPI SWI Compared with Conventional SWI and T2*-Weighted Gradient Recalled-Echo for Routine Clinical Brain MRI at 3T

Cited by 38 publications

References 24 publications

Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19

Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19

A systematic review of ongoing clinical trials in optic pathway gliomas

Evaluation of Ultrafast Wave-CAIPI MPRAGE for Visual Grading and Automated Measurement of Brain Tissue Volume

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