Validation of glycated albumin reference interval in healthy Caucasian pregnant women

Agnello, Luisa; Giglio, Rosaria Vincenza; Sasso, Bruna Lo; Vidali, Matteo; Pedone, S.; Massa, Davide; Ciaccio, Anna Maria; Gambino, Caterina Maria; Ciaccio, Marcello

doi:10.1007/s00592-022-01992-y

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Blood glucose, glycated albumin (GA), and glycated hemoglobin are the three main indicators used to regulate blood glucose levels in individuals with diabetes. A traditional blood glucose test determines the amount of glucose in human blood, which varies based on dietary intake, physical activity, and health status [ 1 ]. HbA1c is a blood test that estimates average glucose levels during a two-month period.…”

Section: Introductionmentioning

confidence: 99%

A selective LSPR biosensor for molecular-level glycated albumin detection

Mondal,

Hossain,

Birbilis

2023

Heliyon

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Section: Introductionmentioning

confidence: 99%

A selective LSPR biosensor for molecular-level glycated albumin detection

Mondal,

Hossain,

Birbilis

2023

Heliyon

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HbA1c or fructosamine on evaluating glucose intolerance in children with beta- thalassemia

Mahmoud,

El-Hawy,

Allam

et al. 2024

Pediatr Res

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Background Beta-thalassemia major (β-TM) patients are more likely to experience blood glucose intolerance and to date; the blood markers that could evaluate this are debatable. So, this study aimed to assess the roles of glycated hemoglobin A1c (HbA1c) and fructosamine in evaluating glucose intolerance in children with β-TM and figuring out role of insulin resistance in these patients. Methods One hundred children diagnosed with β-TM and 100 age and sex-matched controls were enrolled. Fasting plasma glucose (FPG), 2-h post-prandial blood glucose (2-h PG), HbA1c, fructosamine, fasting insulin level (FINS), insulin resistance index (HOMA-IR), and insulin sensitivity index (HOMA-IS) were evaluated. Results FPG and 2-h PG revealed glucose intolerance in 51 patients (51%), 19 of them had diabetes mellitus. HbA1c, fructosamine, FINS, and HOMA-IR showed a high statistically significant increase in patients compared to controls, (P < 0.001). Results revealed fructosamine was more specific in detecting prediabetes state and more sensitive in identifying diabetes mellitus in our patients when compared to HbA1c. Conclusions Despite controversies on HbA1c in children with β-TM, it is still valuable in glucose intolerance detection. Fructosamine showed more sensitivity and specificity. Furthermore, insulin resistance was prevalent in children with β-TM highlighting the necessity of regular glycemic state evaluation. Impact Glucose intolerance is a common complication in beta thalassemia patients. Conflicting data was reported about the role of HbA1c and fructosamine in evaluating glucose intolerance in thalassemic patients. Fructosamine does not yet have a threshold that may be used to distinguish between patients who have diabetes mellitus and those who do not. Fructosamine was more specific in detecting blood glucose intolerance compared to HbA1c and was more sensitive for diagnosing diabetes mellitus. Insulin resistance was common in patients with beta-thalassemia and often present before the onset of overt diabetes.

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Validation of glycated albumin reference interval in healthy Caucasian pregnant women

Cited by 2 publications

References 5 publications

A selective LSPR biosensor for molecular-level glycated albumin detection

A selective LSPR biosensor for molecular-level glycated albumin detection

HbA1c or fructosamine on evaluating glucose intolerance in children with beta- thalassemia

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