“…S. cerevisiae has been
exploited to study proteins implicated in neurodegenerative disorders including Huntington's disease
(Willingham et al ., 2003; Giorgini et al ., 2005) and Parkinson's
disease (Zhang et al ., 1994; Outeiro and Lindquist, 2003; Flower
et al ., 2005). Yeast model systems have been exploited to study
toxicity, aggregation, and localization of Aβ or as facile systems for identification of
compounds influencing Aβ oligomerization (Zhang
et al ., 1994, 1997; Komano et al ., 1998; Caine et al ., 2007; Macreadie et al ., 2008; Winderickx
et al ., 2008; Treusch
et al ., 2011). As indicated, protein tau has also been strongly
correlated with several neuropathies, including AD.…”