Validation of disease activity indices using the 28 joint counts in systemic sclerosis

Lóránd, Veronika; Bálint, Zsófia; Komjáti, Dalma; Németh, Balázs; Minier, Tünde; Kumánovics, Gabór; Farkas, Nelli; Czirják, László; Varjú, Cecília; centers, contributing Eustar

doi:10.1093/rheumatology/kew246

Cited by 20 publications

(24 citation statements)

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“…In a recent large multicentre prospective investigation of consecutive SSc cases ("DeSScipher" study) the prevalence of at least two tender and swollen joints of the hands was 10% of the 2162 enrolled cases (unpublished data). Our recent data also showed that tender/swollen joints were most often present in the metacarpophalangeal (MCP) line and wrist (40). Otherwise, occasionally temporomandibular joints may also be involved (41)(42)(43).…”

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confidence: 87%

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Musculoskeletal Involvement in Systemic Sclerosis: An Unexplored Aspect of the Disease

Varjú

Péntek

Lóránd³

et al. 2016

Journal of Scleroderma and Related Disorders

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efficient therapy for this very important aspect of SSc affecting the majority of the patients. Articular involvement Joint involvement in SSc mainly affects the hands and leads to significant irreversible damage (5-10). In a Canadian self-administered online survey (11) of 464 SSc patients, complaints related to impaired hand function were reported by about three-quarters of the patients. More specifically, an impaired hand function included hand stiffness and joint pain in 81%, swollen joints in 61% of the cases. Physical examination by physicians in the EUSTAR cohort of 7286 SSc patients (3) showed an overall prevalence of arthritis (i.e., tender and swollen joints) in only 16% of the cases. The prevalence of joint contractures was 31% (3). In the diffuse (dc)SSc subset, the functional impairment is often rapid and early, appearing within the first 18 months after onset of the disease in about half of the patients (12). Joint involvement, including arthritis or arthralgia may be one of the very first disease symptoms, therefore it is important to screen each patient

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confidence: 87%

“…We have recently validated the RA-related disease activity indices (DAIs) in SSc for truth, discrimination and feasibility (40). Seventy-seven patients with SSc, 40 RA patients, 20 patients with primary Raynaud's syndrome (PR), and 28 healthy volunteers were assessed.…”

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confidence: 99%

Musculoskeletal Involvement in Systemic Sclerosis: An Unexplored Aspect of the Disease

Varjú

Péntek

Lóránd³

et al. 2016

Journal of Scleroderma and Related Disorders

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“…The reliability and validity of DAS28 have been established in previous studies. Cronbach's α of DAS28 coefficient ranged from 0.65–0.94 and test–retest reliability ranged from 0.85–0.92 (Leeb et al, ; Lóránd et al, ; Salaffi, Cimmino, Leardini, Gasparini, & Grassi, ; Uhlig, Kvien, & Pincus, ; Walsh et al, ). DAS28 was well‐correlated with health assessment questionnaire (HAQ) and disease activity score (DAS; Prevoo et al, ; Salaffi et al, ).…”

Section: The Studymentioning

confidence: 99%

A randomized controlled trial of the Effects of a telehealth educational intervention on medication adherence and disease activity in rheumatoid arthritis patients

Song

Reifsnider

Zhao

et al. 2020

Journal of Advanced Nursing

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Aims To examine the effects of a tailored telehealth educational intervention on medication adherence and disease activity in discharged patients with rheumatoid arthritis (RA). Design An un‐blinded randomized controlled trial. Methods A total of 92 eligible patients were recruited from January 2015–December 2015. Participants were randomly assigned to either the intervention (N = 46) or control group (N = 46). The intervention group received four educational sessions delivered through a telephone across a 12‐week intervention. The content of the education mainly included: subject's knowledge about disease; treatment goals; the importance of taking medication correctly; side effect management; remembering to take medication. The control group received only standard care including discharge instructions. Outcome measures included medication adherence and disease activity. Results The intervention group had significantly higher medication adherence compared with the control group at 12th and 24th week. There was no significant difference between two groups in disease activity at 12th and 24th week. Conclusions The telephone‐delivered tailored educational intervention effectively improved medication adherence among discharged patients with rheumatoid arthritis. However, no significant benefits of the intervention on disease activity were detected. Impact Good medication adherence in rheumatoid arthritis patients contributes to controlling symptom and inflammation, preventing the progressive structural damage. This study demonstrated that the telehealth educational intervention could improve patients' medication adherence but did not have a direct impact on clinical condition in the short‐term. The intervention for discharged patients with rheumatoid arthritis can be integrated into the clinical setting by the nursing staff as follow‐up care. Trial registration number: ChiCTR‐IPR‐14005722.

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“…18 The Disease Activity Score 28 using erythrocyte sedimentation rate (DAS28-ESR) and C-reactive protein (DAS28-CRP), the Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index CDAI (all used in RA) have also been shown to be valid for SSc patients, with the DAS28-ESR showing the best performance regarding reliability and construct validity. 7 Joint involvement, specifically synovitis, is associated with elevated levels of acute phase reactants. 11 The responsiveness of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) to change with respect to arthritis symptoms has not been specifically recognized in SSc.…”

Section: Assessing Arthritis In Sscmentioning

confidence: 99%

“…[4][5][6] Unfortunately, the treatment of arthritis in SSc has not yet been studied as a primary outcome in randomized controlled trials (RCTs), and arthritis-specific outcome measures for SSc have not been well validated. 7 Although the best strategies for managing arthritis in SSc have not yet been borne out by arthritis-specific RCTs, rheumatologists caring for patients with SSc must address this complaint regularly. In this review, we describe the spectrum of arthritis and discuss management considerations.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory arthritis in systemic sclerosis: What to do?

Blank

Nwawka

Yusov

et al. 2018

Journal of Scleroderma and Related Disorders

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Musculoskeletal involvement, including arthritis and tendinopathy, is a common and important determinant of disability and impaired quality of life in systemic sclerosis. However, the treatment of arthritis in systemic sclerosis has not been studied as a primary outcome in randomized controlled trials, and arthritis-specific outcome measures for systemic sclerosis have not been sufficiently validated to date. Rheumatologists caring for patients with systemic sclerosis must address these complaints regularly despite the fact that the level of evidence for the treatment of systemic sclerosisrelated inflammatory arthritis is limited. Consensus statements, based on treatments for related musculoskeletal aspects of rheumatoid arthritis, systemic lupus erythematosus, and other autoimmune diseases, support the use of methotrexate and hydroxychloroquine. Newer biologics, which have efficacy in the treatment of other autoimmune conditions, may show promise in the treatment of arthritis in systemic sclerosis. In this article, we review the current literature on the assessment and treatment of systemic sclerosis arthritis in order to address management considerations.

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Validation of disease activity indices using the 28 joint counts in systemic sclerosis

Abstract: All four disease activity composite indices were found to be valid measures for assessing arthritis in SSc. DAS28-ESR showed the best performance regarding reliability and construct validity.

Cited by 20 publications

References 40 publications

Musculoskeletal Involvement in Systemic Sclerosis: An Unexplored Aspect of the Disease

Musculoskeletal Involvement in Systemic Sclerosis: An Unexplored Aspect of the Disease

A randomized controlled trial of the Effects of a telehealth educational intervention on medication adherence and disease activity in rheumatoid arthritis patients

Inflammatory arthritis in systemic sclerosis: What to do?

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