VALIDATION OF DELAYED GADOLINIUM‐ENHANCED MAGNETIC RESONANCE IMAGING OF CARTILAGE AND <scp>T</scp>2 MAPPING FOR QUANTIFYING DISTAL METACARPUS/METATARSUS CARTILAGE THICKNESS IN <scp>T</scp>HOROUGHBRED RACEHORSES

Carstens, Adelia; Kirberger, Robert M.; Dahlberg, Leif; Prozesky, Leon; Fletcher, Lizelle; Lammentausta, Eveliina

doi:10.1111/vru.12002

Cited by 17 publications

(17 citation statements)

References 48 publications

(45 reference statements)

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“…There are few equine studies implementing dGEMRIC . In one study, dGEMRIC was used to predict metacarpophalangeal joint cartilage thickness with high accuracy and repeatability, except at sites in contact with proximal phalanx cartilage . Despite the positive correlations, spatial resolution was limited and likely affected segmentation accuracy.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Recent advances in articular cartilage evaluation using computed tomography and magnetic resonance imaging

Nelson

Kawcak

Barrett

et al. 2018

Equine Veterinary Journal

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Articular cartilage is a critical joint tissue and its evaluation remains a diagnostic challenge in horses. Coupled with a poor capacity for healing, early degenerative changes in articular cartilage are difficult to characterise using routine diagnostic imaging evaluations. Both computed tomography (CT) and magnetic resonance imaging (MRI) provide volumetric joint assessment and highlight morphological and quantitative properties of articular cartilage, improving assessment of this essential tissue. While the use of CT and MRI for joint evaluation is not new, there still remains a shortage of literature and scientific studies on the ability of these methods to evaluate articular cartilage in the horse. This review article summarises current CT and MRI techniques capable of characterising equine articular cartilage, highlights recent advances in these techniques and discusses the numerous methods studied in human subjects that have been minimally investigated in horses. Imaging techniques are presented in terms of their capabilities of offering morphological and quantitative evaluation along with a discussion of their benefits and limitations. Finally, it summarises the current state-of-the-art approaches and identifies unmet clinical imaging needs to propel the advancement of articular cartilage and joint imaging in the horse.

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Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Recent advances in articular cartilage evaluation using computed tomography and magnetic resonance imaging

Nelson

Kawcak

Barrett

et al. 2018

Equine Veterinary Journal

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“…Intraarticular administration is less common due to off-label designations in man but is generally accepted at~2-4 mmol/L [96,235]. In horses, dGEMRIC is used [233,[238][239][240][241], although thin cartilage in the metacarpophalangeal joint reduces segmentation accuracy due to volume averaging [242] and long acquisition times remain a challenge [233]. Use of dGEMRIC includes a 90 min delay to allow sufficient diffusion into articular cartilage, while exercise, joint loading and cartilage thickness influence uptake [236,237].…”

Section: Techniques/usesmentioning

confidence: 99%

“…Use of dGEMRIC includes a 90 min delay to allow sufficient diffusion into articular cartilage, while exercise, joint loading and cartilage thickness influence uptake [236,237]. In horses, dGEMRIC is used [233,[238][239][240][241], although thin cartilage in the metacarpophalangeal joint reduces segmentation accuracy due to volume averaging [242] and long acquisition times remain a challenge [233]. A recently developed cationic agent shows better penetration at 10% the dose of an anionic GCM and holds promise for improved dGEMRIC techniques [243].…”

Section: Techniques/usesmentioning

confidence: 99%

Use of contrast media in computed tomography and magnetic resonance imaging in horses: Techniques, adverse events and opportunities

Nelson

Goodrich

Barrett

et al. 2017

Equine Veterinary Journal

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The use of contrast media in computed tomography (CT) and magnetic resonance imaging (MRI) is increasing in horses. These contrast-enhanced imaging techniques provide improved tissue delineation and evaluation, thereby expanding diagnostic capabilities. While generally considered safe, not all contrast media exhibit the same safety profiles. The safety of contrast media use and descriptions of adverse events occurring in horses are sparsely reported. This review summarises the reported evidence of contrast media use and adverse events that occur in horses, with added contribution from other veterinary species and studies in man for comparison. This comprehensive data set empowers equine clinicians to develop use and monitoring strategies when working with contrast media. Finally, it summarises the current state-of-the-art and highlights the potential applications of contrast-enhanced CT and MRI for assessment of diseased or injured equine tissues, as well as (patho)physiological processes.

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“…Injury of the metacarpophalangeal joint is a frequent cause of pain causing lameness and poor performance in sports horses . While conventional diagnostic imaging techniques like radiography and ultrasonography often fail to identify any abnormalities, the increased use of MRI and scintigraphy have highlighted the importance of bone mineral densification and bone marrow lesions in subchondral bone injury. Subchondral bone injuries of the metacarpophalangeal joint are well recognized in Thoroughbred racehorses, and are also described as a significant cause of pain causing lameness in mature sports horses …”

Section: Introductionmentioning

confidence: 99%

Bone marrow lesions of the distal condyles of the third metacarpal bone are common and not always related to lameness in sports and pleasure horses

Guio

Ségard‐Weisse

Thomas‐Cancian

et al. 2018

Vet Radiology Ultrasound

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Bone marrow lesions of the distal condyles of the third metacarpal bone are common and not always related to lameness in sports and pleasure horses AbstractThe metacarpophalangeal joint is a common site of pain in horses. Little information is available about bone marrow lesions in the distal condyles of the third metacarpal bone in sports and pleasure horses. Aims of this prospective, retrospective, observational study were to evaluate the prevalence of bone marrow lesions in the distal condyles of the third metacarpal bone, to describe their anatomic distribution and to correlate lesions with the presence of lameness and the level and type of activity. All sports and pleasure horses undergoing standing low-field MRI of the front fetlock region between 2009 and 2016 were included and divided into three lameness groups according to the results of diagnostic analgesia. Bone marrow lesions were analyzed and graded by one reader. Grades were compared between anatomical locations and between lameness groups.A total of 166 horses were sampled. The prevalence of bone marrow lesions was 76.5% (127/166).The dorsal aspects of the medial condyle (31%, 39/127) and of the sagittal ridge (28%, 36/127) were the most commonly affected locations. There was no significant difference between both forelimbs (lame limb and non-lame limb) of the same horse. Lesion severity was neither significantly associated with the lameness group nor with the type or level of activity. The prevalence of bone marrow lesions in the distal condyles of the third metacarpal bone is high in this population and the clinical significance is not always clear. Further studies are required to elucidate the clinical significance of this finding in sports and pleasure horses. K E Y W O R D Sequine, fetlock, magnetic resonance imaging, subchondral

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VALIDATION OF DELAYED GADOLINIUM‐ENHANCED MAGNETIC RESONANCE IMAGING OF CARTILAGE AND T2 MAPPING FOR QUANTIFYING DISTAL METACARPUS/METATARSUS CARTILAGE THICKNESS IN THOROUGHBRED RACEHORSES

Abstract: The purpose of this study was to determine whether Delayed Gadolinium-enhanced

Cited by 17 publications

References 48 publications

Recent advances in articular cartilage evaluation using computed tomography and magnetic resonance imaging

Recent advances in articular cartilage evaluation using computed tomography and magnetic resonance imaging

Use of contrast media in computed tomography and magnetic resonance imaging in horses: Techniques, adverse events and opportunities

Bone marrow lesions of the distal condyles of the third metacarpal bone are common and not always related to lameness in sports and pleasure horses

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