Validation of cone-beam computed tomography and magnetic resonance imaging of the porcine spine: a comparative study with multidetector computed tomography and anatomical specimens

Freitas, Ricardo Miguel Costa de; Andrade, Celi Santos; Caldas, José Guilherme Mendes Pereira; Kanas, Alexandre Fligelman; Cabral, Richard Haltí; Tsunemi, Miriam Harumi; Cervantes, Hernán J.; Rabbani, Said

doi:10.1016/j.spinee.2015.01.017

Cited by 1 publication

(2 citation statements)

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“…The thoracic and lumbar segments of each spine were quantitatively analyzed by the same investigator (LB) and the spinal formula recorded. Morphometric analysis of the spine was performed according to established methods [ 11 , 14 , 16 , 17 ]. Area measurements were made of the spinal cord (SC), vertebral body (VB), dural sac (DS), and vertebral canal (VC) at the mid-body and the intervertebral disc space of each spinal segment ( Fig 4 ).…”

Section: Methodsmentioning

confidence: 99%

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Computed tomography myelography technique and spinal morphometry in healthy Yucatan pigs

et al. 2022

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Porcine models of spinal cord injury (SCI) have an irreplaceable role in the development of experimental therapies. There is little literature regarding CT myelogram (CTM) techniques in swine and morphometry in miniature swine has not been established. A CT-guided method for performing myelography as well as reference values for spinal morphometry in healthy Yucatan miniature swine is lacking. The goal of this study is to describe a CT-guided method of performing CTM in a porcine model of SCI and to establish spinal morphometric reference values in mature Yucatan pigs. Six healthy, Yucatan sows, 9 months of age, weighing between 39–57.7kg, with no history of spinal disease, spinal injury, or neurologic deficits on physical exam were used in this study. CT myelography was performed in each sow under general anesthesia. CT scout images were used to guide needle placement at the L3-L4 intervertebral site. Once correct needle placement was confirmed using a 1ml test injection, a full dose of iodinated contrast (0.3ml/kg) was injected slowly over a 2-minute time period. Morphometry was performed using area measurements of the spinal cord (SC), vertebral body (VB), dural sac (DS), and vertebral canal (VC) at the mid-body and the intervertebral disc space of each spinal segment. Of the quantitative measurements, the spinal cord surface area had the widest range of values and the greatest coefficient of variance (CV) while those parameters for the vertebral canal had a low CV. Of the morphometric ratios, the DS:VC, had the lowest CV while the spinal cord ratios to DS and VC had the highest (>30). The vertebral canal surface area and the dural space: vertebral canal ratio may serve as reference values in future studies using this animal model.

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Section: Methodsmentioning

confidence: 99%

“…There is little literature regarding CT myelogram techniques in swine. In one study, multidetector CT, cone-beam CT and MRI were compared for morphometric analysis of Landrace swine cadavers, a domestic commercial breed [ 14 ]. However, CTM techniques and morphometry in miniature swine have not been established.…”

Section: Introductionmentioning

confidence: 99%