Validation of Computational Fluid Dynamics in CT-based Airway Models with SPECT/CT

Backer, Jan W. De; Vos, Wim; Vinchurkar, Samir; Claes, Rita; Drollmann, Anton; Wulfrank, D; Parizel, Paul M.; Germonpré, Paul; Backer, Wilfried De

doi:10.1148/radiol.10100322

Cited by 156 publications

(196 citation statements)

References 31 publications

Supporting

Mentioning

187

Contrasting

Unclassified

Order By: Relevance

“…This validated technique provides detailed information on how distinct geometrical features correlate with airflow distribution and provides information on pressure 7, 8, 12. Our results demonstrate an increasing pressure drop at the distal segment of the transplanted trachea due to the jet shown in Figure 3 and highlighted the area most in need of intervention with a corresponding improvement in symptomatology following targeted treatment.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Tissue-Engineered Tracheal Replacement in a Child: A 4-Year Follow-Up Study

Hamilton

Kanani

Roebuck

et al. 2015

American Journal of Transplantation

161

145

View full text Add to dashboard Cite

In 2010, a tissue‐engineered trachea was transplanted into a 10‐year‐old child using a decellularized deceased donor trachea repopulated with the recipient's respiratory epithelium and mesenchymal stromal cells. We report the child's clinical progress, tracheal epithelialization and costs over the 4 years. A chronology of events was derived from clinical notes and costs determined using reference costs per procedure. Serial tracheoscopy images, lung function tests and anti‐HLA blood samples were compared. Epithelial morphology and T cell, Ki67 and cleaved caspase 3 activity were examined. Computational fluid dynamic simulations determined flow, velocity and airway pressure drops. After the first year following transplantation, the number of interventions fell and the child is currently clinically well and continues in education. Endoscopy demonstrated a complete mucosal lining at 15 months, despite retention of a stent. Histocytology indicates a differentiated respiratory layer and no abnormal immune activity. Computational fluid dynamic analysis demonstrated increased velocity and pressure drops around a distal tracheal narrowing. Cross‐sectional area analysis showed restriction of growth within an area of in‐stent stenosis. This report demonstrates the long‐term viability of a decellularized tissue‐engineered trachea within a child. Further research is needed to develop bioengineered pediatric tracheal replacements with lower morbidity, better biomechanics and lower costs.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Cross‐sectional area of the trachea was calculated following methods previously described 7. Tracheal airflow was calculated using a validated method through computational fluid dynamics 8, 9.…”

Section: Methodsmentioning

confidence: 99%

Tissue-Engineered Tracheal Replacement in a Child: A 4-Year Follow-Up Study

Hamilton

Kanani

Roebuck

et al. 2015

American Journal of Transplantation

161

145

View full text Add to dashboard Cite

show abstract

“…The main concern of the large-scale studies performed was that they did not assess the effect of roflumilast in addition to a combination product such as long-acting b 2 -agonists (LABA) or long-acting muscarinic agents (LAMA) combined with inhaled corticosteroids (ICS) [2]. A novel technology called functional respiratory imaging (FRI) defines, in great detail, lung geometry and regional changes in airway volume and resistance [3][4][5]. By assessing changes close to the site of action of the intervention, the method is more sensitive (higher effect size) compared with standard pulmonary function tests (PFT) [3].…”

Section: To the Editormentioning

confidence: 99%

“…FRI outcome parameters included: image-based lobar volume at FRC (iLobes_FRC), imagebased airway volume at TLC (iVaw) and image-based airway resistance at TLC (iRaw). More details and validation of FRI can be found in DE BACKER et al [5]. The study was approved by the ethical commissions of all participating centres.…”

Section: To the Editormentioning

confidence: 99%

The effect of roflumilast in addition to LABA/LAMA/ICS treatment in COPD patients

et al. 2014

View full text Add to dashboard Cite

“…De Backer et al [2] and Lambert et al [3] adopted a similar iterative approach based on CT measurements of lobar growth rather than of lung growth. Although such iterative approaches improved the reliability of the numerical predictions of the central airway flow, they are not adequate to accurately capture the non-uniform inner lobar flow distribution.…”

Section: Introductionmentioning

confidence: 99%

Non-uniform central airways ventilation model based on vascular segmentation

Ibrahim

Rona

Hainsworth

2015

Computers in Biology and Medicine

View full text Add to dashboard Cite

Improvements in the understanding of the physiology of the central airways require an appropriate representation of the non-uniform ventilation at its terminal branches. This paper proposes a new technique for estimating the non-uniform ventilation at the terminal branches by modelling the volume change of their distal peripheral airways, based on vascular segmentation. The vascular tree is used for sectioning the dynamic CT-based 3D volume of the lung at 11 time points over the breathing cycle of a research animal. Based on the mechanical coupling between the vascular tree and the remaining lung tissues, the volume change of each individual lung segment over the breathing cycle was used to estimate the non-uniform ventilation of its associated terminal branch. The 3D lung sectioning technique was validated on an airway cast model of the same animal pruned to represent the truncated dynamic CT based airway geometry. The results showed that the 3D lung sectioning technique was able to estimate the volume of the missing peripheral airways within a tolerance of 2%. In addition, the time-varying non-uniform ventilation distribution predicted by the proposed sectioning technique was validated against CT measurements of lobar ventilation and showed good agreement. This significant modelling advance can be used to estimate subject-specific non-uniform boundary conditions to obtain subjectspecific numerical models of the central airway flow.

show abstract

Validation of Computational Fluid Dynamics in CT-based Airway Models with SPECT/CT

Abstract: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10100322/-/DC1.

Cited by 156 publications

References 31 publications

Tissue-Engineered Tracheal Replacement in a Child: A 4-Year Follow-Up Study

Tissue-Engineered Tracheal Replacement in a Child: A 4-Year Follow-Up Study

The effect of roflumilast in addition to LABA/LAMA/ICS treatment in COPD patients

Non-uniform central airways ventilation model based on vascular segmentation

Contact Info

Product

Resources

About