Validation of claims-based algorithms to identify interstitial lung disease in patients with rheumatoid arthritis

Cho, Soo-Kyung; Doyle, Tracy J.; Lee, Hemin; Jin, Yinzhu; Tong, Angela; Ortiz, Adrian J. Santiago; Kim, Seo Young

doi:10.1016/j.semarthrit.2020.04.006

Cited by 17 publications

(18 citation statements)

References 23 publications

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“…As already noted, RA-ILD is a heterogeneous phenotype and the MUC5B promoter variant is only expected to strongly impact UIP risk within RA. Identifying RA-ILD in administrative datasets and institutional biobanks may be inaccurate 15 and could have at least slightly overestimated its incidence in this study. 6 The results emphasise how much more common RA-ILD is compared with the general population, again suggesting that RA-ILD is a distinct entity and not IPF in a patient who happens to have RA.…”

Section: Towards Clinical Significance Of the Muc5b Promoter Variant And Risk Of Rheumatoid Arthritis-associated Interstitial Lung Diseasmentioning

confidence: 84%

Towards clinical significance of the MUC5B promoter variant and risk of rheumatoid arthritis-associated interstitial lung disease

Sparks

2021

Ann Rheum Dis

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Section: Towards Clinical Significance Of the Muc5b Promoter Variant And Risk Of Rheumatoid Arthritis-associated Interstitial Lung Diseasmentioning

confidence: 84%

Towards clinical significance of the MUC5B promoter variant and risk of rheumatoid arthritis-associated interstitial lung disease

Sparks

2021

Ann Rheum Dis

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“…The etiology of Rheumatoid arthritis (RA) is unknown, and this disease is responsible for inflammation of numerous organs and tissues [5][6]. This disease is known to target synovial joints primarily by causing symmetric affection in peripheral joints.…”

Section: Discussionmentioning

confidence: 99%

A Cohort Study to Determine the Prevalence of Pulmonary Manifestations in Rheumatoid Arthritis

Shah

Ahmed

Das

et al. 2021

JPRI

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Background: Rheumatoid arthritis is an ailment that has an effect on the lungs in cases of pleural inflammation; it affects the lower as well as upper lung airways. Other effects of the disease can be seen in interstitial lung problems (parenchyma) and pulmonary vasculature. Aim: Evaluating the occurrence of pulmonary manifestations in RA patients was the objective of this study. Methods: An observatory method that was cross-section in nature was employed in this study which was held in the Rheumatology and Medicine department, Jinnah Medical and Dental College Karachi Pakistan for the one-year duration from June 2020 to June 2021. Eighty subjects were included in this study, and all of them underwent a general examination, their medical history was taken into account. Several lab tests were performed on the patients, ESR, BUN, CRP, HRCT, ALT, radiological investigations, and chest X-rays were included. Results: In this study42 percent of patients presented with pulmonary manifestations. About 45.70 percent of the patients presented with abnormalities in the spirometry test, 42.85 percent showed HRCT abnormalities. The HRCT scores vary with age, TJC (Tender Joint Count), ESR, and SJC.FEV, 1 HRCT, and FCV showed a negative correlation among each other. However other variables did not show any statistically significant correlation. Conclusion: RA showed the prevalence of pulmonary affection, and this can be observed in pulmonary and radiological functions. There was an associationof age, pulmonary functions, and ESR.

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“…One recently published study aimed to validate claims-based algorithms for identification of ILD in patients with RA found that the accuracy of RA-ILD was high if the diagnosis was made by specialists. 30 In the present study, we merely enrolled patients within the aforementioned catastrophic illness registry file. Therefore, the diagnoses of CTD and ILD were made by the rheumatologist, and the risk for misclassification should be at least partly mitigated.…”

Section: Open Accessmentioning

confidence: 99%

Air pollutants and development of interstitial lung disease in patients with connective tissue disease: a population-based case–control study in Taiwan

et al. 2020

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ObjectiveThe aim of this study was to assess the association between air pollutant exposure and interstitial lung disease (ILD) in patients with connective tissue diseases (CTDs).SettingA nationwide, population-based, matched case–control study in Taiwan.ParticipantsUsing the 1997–2013 Taiwanese National Health Insurance Research Database, we identified patients with newly diagnosed CTD during 2001–2013, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), dermatomyositis (DMtis)/polymyositis (PM) and primary Sjögren’s syndrome (pSS).Primary and secondary outcome measuresPatients with newly diagnosed ILD during 2012–2013 were identified as ILD cases, and selected patients with CTD without ILD matching (1:4) the CTD cases for CTD diagnosis, age, gender, disease duration and year of ILD diagnosis date were identified as non-ILD controls. Data of hourly level of air pollutants 1 year before the index date were obtained from the Taiwan Environmental Protection Agency. The association between ILD and air pollutant exposure was evaluated using logistic regression analysis shown as adjusted ORs (aORs) with 95% CIs after adjusting for potential confounders.ResultsWe identified 505 newly diagnosed CTD-ILD patients, including 82 with SLE, 210 with RA, 47 with SSc, 44 with DMtis/PM and 122 with pSS. Ozone (O3) exposure (per 10 ppb) was associated with a decreased ILD risk in patients with CTD (aOR, 0.51; 95% CI, 0.33 to 0.79) after adjusting for potential confounders.ConclusionsA previously unrecognised inverse correlation was found between O3 exposure and ILD in patients with RA and SSc. Further studies are warranted to explore the underlying mechanisms.

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Validation of claims-based algorithms to identify interstitial lung disease in patients with rheumatoid arthritis

Cited by 17 publications

References 23 publications

Towards clinical significance of the MUC5B promoter variant and risk of rheumatoid arthritis-associated interstitial lung disease

Towards clinical significance of the MUC5B promoter variant and risk of rheumatoid arthritis-associated interstitial lung disease

A Cohort Study to Determine the Prevalence of Pulmonary Manifestations in Rheumatoid Arthritis

Air pollutants and development of interstitial lung disease in patients with connective tissue disease: a population-based case–control study in Taiwan

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